6UKT
Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | PF00503 | e6uktB2 | A: alpha arrays | X: Transducin (alpha subunit), insertion domain (From Topology) | H: Transducin (alpha subunit), insertion domain (From Topology) | T: Transducin (alpha subunit), insertion domain | F: PF00503 | ECOD (1.6) |
B | PF00503 | e6uktB1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00503 | ECOD (1.6) |
C | PF07686 | e6uktC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
D | PF07686 | e6uktD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
E | PF07686 | e6uktE1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
F | PF07686 | e6uktF1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
Heavy Chain | IGHV1 | - | resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) | SAbDab (2024-05-24) | |
Heavy Chain | IGHV1 | - | resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) | SAbDab (2024-05-24) | |
Heavy Chain | IGHV1 | - | resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) | SAbDab (2024-05-24) | |
Heavy Chain | IGHV1 | - | guanine nucleotide-binding protein g(i) subunit alpha-1 | SAbDab (2024-05-24) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF10165 | Guanine nucleotide exchange factor synembryn (Ric8) | Guanine nucleotide exchange factor synembryn | - | Family | |
PF00503 | G-protein alpha subunit (G-alpha) | G-protein alpha subunit | G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ... | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR016024 | Armadillo-type fold | Homologous Superfamily | |
IPR008376 | Synembryn | Domain | |
IPR019318 | Guanine nucleotide exchange factor, Ric8 | Family | |
IPR011989 | Armadillo-like helical | Homologous Superfamily | |
IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit | Family | |
IPR011025 | G protein alpha subunit, helical insertion | Homologous Superfamily | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR001408 | G-protein alpha subunit, group I | Family |