Annotations: 6UJB

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Integrin alpha N-terminal domain	8041564	3000314	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Integrin domains	8055305	3002062	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Integrin_alpha2_1st	e6ujbA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Integrin_alpha2_1st	ECOD (1.6)
A	FG-GAP_1st	e6ujbA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: FG-GAP_1st	ECOD (1.6)
B	INB	e6ujbB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: INB	ECOD (1.6)
B	Integrin_beta	e6ujbB2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: Integrin_beta	ECOD (1.6)
C [auth E]	V-set_8	e6ujbE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
D [auth F]	V-set	e6ujbF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.130	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (utative)
A	2.60.40.1460	Mainly Beta	Sandwich	Immunoglobulin-like	Integrin domains. Chain A, domain 2	CATH (utative)
B	3.40.50.410	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	von Willebrand factor, type A domain	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
C [auth E]	Fab C6D4,anti-TGF	VH-CH1	Mus musculus (house mouse)	IGHV9-2-101, IGHJ201, IGHG2A01, IGHG2A02	V-DOMAIN VH, C-DOMAIN CH1	IG	(L-KAPPA)	IMGT (202415-0)
D [auth F]	Fab C6D4,anti-TGF	L-KAPPA	Mus musculus (house mouse)	IGKV8-2101, IGKJ501, IGKC01, IGKC02	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	(L-KAPPA)	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C [auth E]	Heavy Chain	IGHV9	-	integrin beta-8 \| integrin alpha-v	SAbDab (2024-04-19)
D [auth F]	Light Chain	IGKV8	Kappa	integrin beta-8 \| integrin alpha-v	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01839	FG-GAP repeat (FG-GAP)	FG-GAP repeat	-	Repeat
A	PF08441	Integrin alpha Ig-like domain 1 (Integrin_A_Ig_1)	Integrin alpha Ig-like domain 1	This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of an immunoglobulin-like domain.	Domain
B	PF00362	Integrin beta chain VWA domain (Integrin_beta)	Integrin beta chain VWA domain	Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Integrin alpha-V	molecular transducer activity coreceptor activity signaling receptor activity protein binding binding extracellular matrix protein binding fibronectin binding opsonin binding cation binding ion binding metal ion binding small molecule binding virus receptor activity exogenous protein binding molecular transducer activity coreceptor activity signaling receptor activity protein binding binding extracellular matrix protein binding fibronectin binding opsonin binding cation binding ion binding metal ion binding small molecule binding virus receptor activity exogenous protein binding extracellular matrix binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity enzyme binding protease binding transforming growth factor beta binding growth factor binding cytokine binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding kinase binding protein kinase C binding protein kinase binding	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction regulation of localization regulation of biological process negative regulation of lipid transport transport regulation of transport organic substance transport biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction regulation of localization regulation of biological process negative regulation of lipid transport transport regulation of transport organic substance transport biological regulation negative regulation of biological process lipid localization lipid transport negative regulation of transport regulation of lipid transport establishment of localization negative regulation of lipid localization localization regulation of lipid localization macromolecule localization cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular process multicellular organismal process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process cytokine production organic substance biosynthetic process metabolic process macromolecule metabolic process transforming growth factor beta production cell migration cell motility lipid storage maintenance of location regulation of lipid storage negative regulation of lipid storage monoatomic ion transmembrane transport inorganic ion transmembrane transport calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cellular response to stimulus regulation of cellular process signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction apoptotic process programmed cell death cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation positive regulation of biological process osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation positive regulation of cellular process import into cell regulation of cellular component organization regulation of phagocytosis regulation of vesicle-mediated transport vesicle-mediated transport cellular component organization phagocytosis cellular component organization or biogenesis endocytosis regulation of endocytosis positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling negative regulation of endocytosis negative regulation of cellular process negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis negative regulation of molecular function regulation of molecular function negative regulation of low-density lipoprotein receptor activity receptor-mediated endocytosis developmental process wound healing epithelium development morphogenesis of an epithelium epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis response to stress anatomical structure development epiboly wound healing, spreading of cells response to wounding chemotaxis negative chemotaxis taxis response to chemical response to external stimulus locomotion negative regulation of signaling regulation of programmed cell death negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of apoptotic signaling pathway lipoprotein metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of lipoprotein metabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of lipoprotein metabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of metabolic process heterotypic cell-cell adhesion cell-cell adhesion apoptotic cell clearance modulation by symbiont of entry into host negative regulation of entry of bacterium into host cell entry of bacterium into host cell regulation of entry of bacterium into host cell regulation of biological process involved in symbiotic interaction cell-matrix adhesion regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation positive regulation of cytosolic calcium ion concentration regulation of biological quality blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development apolipoprotein A-I-mediated signaling pathway intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade formation of primary germ layer embryonic morphogenesis embryo development gastrulation endoderm development endoderm formation endodermal cell differentiation integrin-mediated signaling pathway cell adhesion mediated by integrin positive regulation of cell adhesion regulation of cell adhesion vasculogenesis positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule cell periphery protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex alphav-beta3 integrin-PKCalpha complex cell surface external side of plasma membrane side of membrane receptor complex integrin alphav-beta5 complex integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion integrin alphav-beta8 complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol plasma membrane bounded cell projection cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane alphav-beta3 integrin-HMGB1 complex alphav-beta3 integrin-IGF-1-IGF1R complex integrin alphav-beta3 complex anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge leading edge membrane ruffle membrane phagocytic vesicle endocytic vesicle integrin alphav-beta1 complex lamellipodium membrane lamellipodium integrin alphav-beta6 complex filopodium membrane filopodium
B	Integrin beta-8	protein binding binding extracellular matrix protein binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process response to stimulus immune response immune system process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction hard palate development secondary palate development roof of mouth development ceramide metabolic process membrane lipid metabolic process organonitrogen compound metabolic process glycosphingolipid metabolic process glycolipid metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process sphingolipid metabolic process primary metabolic process cellular lipid metabolic process amide metabolic process ganglioside metabolic process lipid metabolic process placenta blood vessel development placenta development vasculature development circulatory system development blood vessel development myeloid leukocyte differentiation cellular developmental process myeloid dendritic cell activation hemopoiesis Langerhans cell differentiation cell activation cell development mononuclear cell differentiation myeloid leukocyte activation leukocyte activation myeloid cell differentiation cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation leukocyte differentiation blood vessel morphogenesis tube development vasculogenesis anatomical structure morphogenesis tube morphogenesis regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery integrin complex plasma membrane signaling receptor complex anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion integrin alphav-beta8 complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface
C [auth E]	C6D4 heavy chain Fab	-	-	-
D [auth F]	C6D4 light chain Fab	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013517	FG-GAP repeat	Repeat
A	IPR048286	Integrin alpha, third immunoglobulin-like domain	Domain
A	IPR013649	Integrin alpha, first immunoglubulin-like domain	Domain
A	IPR048285	Integrin alpha, second immunoglobulin-like domain	Domain
A	IPR032695	Integrin domain superfamily	Homologous Superfamily
A	IPR013519	Integrin alpha beta-propellor	Repeat
A	IPR000413	Integrin alpha chain	Family
A	IPR028994	Integrin alpha, N-terminal	Homologous Superfamily
A	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	Conserved Site
B	IPR033760	Integrin beta N-terminal	Domain
B	IPR013111	EGF-like domain, extracellular	Domain
B	IPR015812	Integrin beta subunit	Family
B	IPR002369	Integrin beta subunit, VWA domain	Domain
B	IPR016201	PSI domain	Domain
B	IPR000742	EGF-like domain	Domain
B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B	IPR032695	Integrin domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P06756	Acute Cerebrovascular Accidents glioblastoma intracerebral hemorrhage myopathy osteosarcoma rheumatoid arthritis breast cancer cerebrovascular disorder hereditary spastic paraplegia large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer tuberculosis diabetes mellitus inflammatory bowel disease Acute Cerebrovascular Accidents glioblastoma intracerebral hemorrhage myopathy osteosarcoma rheumatoid arthritis breast cancer cerebrovascular disorder hereditary spastic paraplegia large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer tuberculosis diabetes mellitus inflammatory bowel disease medulloblastoma non-small cell lung carcinoma pilocytic astrocytoma
B	Pharos: P26012	inflammatory bowel disease endometriosis pilocytic astrocytoma Prostate cancer, familial spina bifida allergic rhinitis breast cancer lung carcinoma malignant glioma osteosarcoma primary biliary cholangitis prostate carcinoma tuberculosis astrocytic tumor chronic obstructive pulmonary disease inflammatory bowel disease endometriosis pilocytic astrocytoma Prostate cancer, familial spina bifida allergic rhinitis breast cancer lung carcinoma malignant glioma osteosarcoma primary biliary cholangitis prostate carcinoma tuberculosis astrocytic tumor chronic obstructive pulmonary disease large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor psoriasis atypical teratoid rhabdoid tumor cystic fibrosis glioblastoma lung cancer malignant ependymoma oligodendroglioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.