Annotations: 6UJA

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Integrin domains	8055305	3002062	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Integrin alpha N-terminal domain	8041564	3000314	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	pro-TGF beta-like	8089959	3002405	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Integrin_alpha2_1st	e6ujaA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Integrin_alpha2_1st	ECOD (1.6)
A	FG-GAP_1st	e6ujaA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: FG-GAP_1st	ECOD (1.6)
B	INB	e6ujaB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: INB	ECOD (1.6)
B	Integrin_beta	e6ujaB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: Integrin_beta	ECOD (1.6)
C [auth D]	TGFb_propeptide	e6ujaD1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: TGFb_propeptide	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.130	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (utative)
A	2.60.40.1460	Mainly Beta	Sandwich	Immunoglobulin-like	Integrin domains. Chain A, domain 2	CATH (utative)
B	3.40.50.410	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	von Willebrand factor, type A domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01839	FG-GAP repeat (FG-GAP)	FG-GAP repeat	-	Repeat
A	PF08441	Integrin alpha Ig-like domain 1 (Integrin_A_Ig_1)	Integrin alpha Ig-like domain 1	This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of an immunoglobulin-like domain.	Domain
B	PF00362	Integrin beta chain VWA domain (Integrin_beta)	Integrin beta chain VWA domain	Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain.	Domain
C [auth D]	PF00688	TGF-beta propeptide (TGFb_propeptide)	TGF-beta propeptide	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Integrin alpha-V	molecular transducer activity coreceptor activity signaling receptor activity protein binding binding extracellular matrix protein binding fibronectin binding opsonin binding cation binding ion binding metal ion binding small molecule binding virus receptor activity exogenous protein binding molecular transducer activity coreceptor activity signaling receptor activity protein binding binding extracellular matrix protein binding fibronectin binding opsonin binding cation binding ion binding metal ion binding small molecule binding virus receptor activity exogenous protein binding extracellular matrix binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity enzyme binding protease binding transforming growth factor beta binding growth factor binding cytokine binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding kinase binding protein kinase C binding protein kinase binding	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction regulation of localization regulation of biological process negative regulation of lipid transport transport regulation of transport organic substance transport biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction regulation of localization regulation of biological process negative regulation of lipid transport transport regulation of transport organic substance transport biological regulation negative regulation of biological process lipid localization lipid transport negative regulation of transport regulation of lipid transport establishment of localization negative regulation of lipid localization localization regulation of lipid localization macromolecule localization cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular process multicellular organismal process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process cytokine production organic substance biosynthetic process metabolic process macromolecule metabolic process transforming growth factor beta production cell migration cell motility lipid storage maintenance of location regulation of lipid storage negative regulation of lipid storage monoatomic ion transmembrane transport inorganic ion transmembrane transport calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cellular response to stimulus regulation of cellular process signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction apoptotic process programmed cell death cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation positive regulation of biological process osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation positive regulation of cellular process import into cell regulation of cellular component organization regulation of phagocytosis regulation of vesicle-mediated transport vesicle-mediated transport cellular component organization phagocytosis cellular component organization or biogenesis endocytosis regulation of endocytosis positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling negative regulation of endocytosis negative regulation of cellular process negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis negative regulation of molecular function regulation of molecular function negative regulation of low-density lipoprotein receptor activity receptor-mediated endocytosis developmental process wound healing epithelium development morphogenesis of an epithelium epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis response to stress anatomical structure development epiboly wound healing, spreading of cells response to wounding chemotaxis negative chemotaxis taxis response to chemical response to external stimulus locomotion negative regulation of signaling regulation of programmed cell death negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of apoptotic signaling pathway lipoprotein metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of lipoprotein metabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of lipoprotein metabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of metabolic process heterotypic cell-cell adhesion cell-cell adhesion apoptotic cell clearance modulation by symbiont of entry into host negative regulation of entry of bacterium into host cell entry of bacterium into host cell regulation of entry of bacterium into host cell regulation of biological process involved in symbiotic interaction cell-matrix adhesion regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation positive regulation of cytosolic calcium ion concentration regulation of biological quality blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development apolipoprotein A-I-mediated signaling pathway intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade formation of primary germ layer embryonic morphogenesis embryo development gastrulation endoderm development endoderm formation endodermal cell differentiation integrin-mediated signaling pathway cell adhesion mediated by integrin positive regulation of cell adhesion regulation of cell adhesion vasculogenesis positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule cell periphery protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex alphav-beta3 integrin-PKCalpha complex cell surface external side of plasma membrane side of membrane receptor complex integrin alphav-beta5 complex integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion integrin alphav-beta8 complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol plasma membrane bounded cell projection cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane alphav-beta3 integrin-HMGB1 complex alphav-beta3 integrin-IGF-1-IGF1R complex integrin alphav-beta3 complex anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge leading edge membrane ruffle membrane phagocytic vesicle endocytic vesicle integrin alphav-beta1 complex lamellipodium membrane lamellipodium integrin alphav-beta6 complex filopodium membrane filopodium
B	Integrin beta-8	protein binding binding extracellular matrix protein binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process response to stimulus immune response immune system process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway signaling cell communication signal transduction hard palate development secondary palate development roof of mouth development ceramide metabolic process membrane lipid metabolic process organonitrogen compound metabolic process glycosphingolipid metabolic process glycolipid metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process sphingolipid metabolic process primary metabolic process cellular lipid metabolic process amide metabolic process ganglioside metabolic process lipid metabolic process placenta blood vessel development placenta development vasculature development circulatory system development blood vessel development myeloid leukocyte differentiation cellular developmental process myeloid dendritic cell activation hemopoiesis Langerhans cell differentiation cell activation cell development mononuclear cell differentiation myeloid leukocyte activation leukocyte activation myeloid cell differentiation cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation leukocyte differentiation blood vessel morphogenesis tube development vasculogenesis anatomical structure morphogenesis tube morphogenesis regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery integrin complex plasma membrane signaling receptor complex anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion integrin alphav-beta8 complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface
C [auth D]	Transforming growth factor beta-1 proprotein	transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity antigen binding signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity identical protein binding type II transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding cytokine activity	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development cellular metabolic process reactive oxygen species metabolic process regulation of superoxide metabolic process regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of metabolic process regulation of reactive oxygen species metabolic process immune system development lymph node development immune system process hematopoietic or lymphoid organ development multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis surfactant homeostasis regulation of animal organ morphogenesis regulation of developmental process regulation of odontogenesis odontogenesis positive regulation of odontogenesis positive regulation of developmental process positive regulation of animal organ morphogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of anatomical structure morphogenesis canonical Wnt signaling pathway Wnt signaling pathway tolerance induction to self antigen tolerance induction chemotaxis positive regulation of locomotion regulation of response to external stimulus response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to external stimulus taxis response to chemical regulation of locomotion locomotion regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation negative regulation of lymphocyte proliferation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular developmental process hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation cell differentiation regulatory T cell differentiation T cell differentiation leukocyte differentiation regulation of molecular function regulation of DNA binding regulation of binding embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure developmental maturation epithelial cell differentiation epithelial cell development columnar/cuboidal epithelial cell development anatomical structure maturation epithelial cell maturation cell maturation columnar/cuboidal epithelial cell differentiation columnar/cuboidal epithelial cell maturation cell morphogenesis response to stress response to wounding regulation of immune effector process negative regulation of macrophage cytokine production cytokine production organic substance biosynthetic process negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response immune response negative regulation of immune effector process negative regulation of cellular biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process regulation of macrophage cytokine production negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response cellular biosynthetic process regulation of cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process macrophage cytokine production ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process small molecule metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process connective tissue development skeletal system development chondrocyte differentiation cartilage development branching involved in mammary gland duct morphogenesis development of secondary female sexual characteristics mammary gland morphogenesis reproductive process mammary gland development branching morphogenesis of an epithelial tube mammary gland branching involved in thelarche developmental process involved in reproduction thelarche development of secondary sexual characteristics mammary gland duct morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium interleukin-17 production negative regulation of interleukin-17 production regulation of interleukin-17 production negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleic acid metabolic process Notch signaling pathway organonitrogen compound catabolic process mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process organic substance catabolic process respiratory tube development bronchiole development lung development respiratory system development cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway fat cell differentiation negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation positive regulation of protein metabolic process positive regulation of macromolecule metabolic process sensory organ development retina vasculature development in camera-type eye eye development retina development in camera-type eye visual system development vasculature development circulatory system development camera-type eye development sensory system development regulation of cartilage development regulation of multicellular organismal development positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade sexual reproduction multicellular organismal reproductive process germ cell migration cell migration cell motility gamete generation regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of cell differentiation epithelial to mesenchymal transition mesenchymal cell differentiation regulation of cellular component organization positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization extracellular matrix organization regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly cellular component organization or biogenesis regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization regulation of muscle tissue development skeletal muscle tissue development negative regulation of muscle tissue development regulation of skeletal muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development negative regulation of skeletal muscle tissue development regulation of leukocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation positive regulation of leukocyte activation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis regulation of lymphocyte differentiation positive regulation of cell adhesion regulation of regulatory T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation interleukin-23 production regulation of interleukin-23 production positive regulation of cell population proliferation heart development heart valve development aortic valve development heart valve morphogenesis semi-lunar valve development aortic valve morphogenesis membrane protein intracellular domain proteolysis proteolysis membrane protein proteolysis regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration regulation of epithelial cell migration positive regulation of blood vessel endothelial cell migration epithelium migration positive regulation of endothelial cell migration myeloid leukocyte differentiation myeloid dendritic cell activation Langerhans cell differentiation myeloid leukocyte activation myeloid cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation epithelial cell proliferation neuron apoptotic process apoptotic process cell death programmed cell death blood vessel morphogenesis vasculogenesis blood vessel development embryonic organ development embryonic liver development positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of gene expression positive regulation of interleukin-17 production positive regulation of cytokine production positive regulation of cellular biosynthetic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response osteoclast differentiation positive regulation of nervous system development regulation of neurogenesis positive regulation of gliogenesis gliogenesis microglia differentiation regulation of macrophage differentiation regulation of microglia differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation central nervous system development positive regulation of microglia differentiation regulation of gliogenesis regulation of nervous system development neurogenesis positive regulation of neurogenesis regulation of myeloid cell differentiation macrophage differentiation regulation of glial cell differentiation positive regulation of glial cell differentiation glial cell differentiation positive regulation of myeloid cell differentiation defense response inflammatory response ossification regulation of ossification negative regulation of ossification regulation of localization transport regulation of transport regulation of monoatomic ion transport regulation of sodium ion transport establishment of localization metal ion transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport sodium ion transport lung alveolus development response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport regulation of protein localization nuclear transport regulation of protein localization to nucleus import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus regulation of intracellular transport organic substance transport regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of protein localization to organelle protein transport regulation of cellular localization macromolecule localization protein localization to organelle regulation of intracellular protein transport intracellular protein transport lens fiber cell differentiation lens development in camera-type eye phospholipid homeostasis lipid homeostasis response to ketone response to progesterone response to hormone response to steroid hormone protein-containing complex organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of cell cycle cell cycle regulation of cell cycle response to sterol response to alcohol response to cholesterol response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth extrinsic apoptotic signaling pathway apoptotic signaling pathway inorganic ion homeostasis intracellular calcium ion homeostasis calcium ion homeostasis cellular homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation positive regulation of cell division cell division regulation of cell division positive regulation of establishment of protein localization positive regulation of protein localization to nucleus positive regulation of protein import into nucleus positive regulation of protein localization positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport positive regulation of protein transport positive regulation of intracellular transport positive regulation of transport negative regulation of locomotion negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of epithelial cell migration negative regulation of cell migration negative regulation of cell motility regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development ventricular cardiac muscle tissue development cardiac chamber development cardiac chamber morphogenesis cardiac muscle tissue development muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth regulation of biomineral tissue development biomineral tissue development amelogenesis regulation of tooth mineralization regulation of enamel mineralization muscle cell cellular homeostasis regulation of branching involved in mammary gland duct morphogenesis regulation of morphogenesis of an epithelium regulation of morphogenesis of a branching structure receptor catabolic process cellular catabolic process receptor metabolic process regulation of striated muscle tissue development regulation of muscle organ development regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus head development face morphogenesis head morphogenesis face development body morphogenesis negative regulation of myoblast differentiation regulation of myoblast differentiation myoblast differentiation fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration endoderm development leukocyte homeostasis T cell homeostasis homeostasis of number of cells lymphocyte homeostasis ureteric bud development mesonephric epithelium development kidney epithelium development mesonephros development renal system development kidney development mesonephric tubule development oligodendrocyte development glial cell development oligodendrocyte differentiation positive regulation of secretion by cell protein localization to extracellular region regulation of secretion by cell secretion by cell positive regulation of secretion secretion establishment of protein localization to extracellular region export from cell protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion neuroepithelial cell differentiation odontoblast differentiation negative regulation of biomineral tissue development protein dephosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation positive regulation of protein dephosphorylation branch elongation involved in mammary gland duct branching developmental growth axis elongation branch elongation of an epithelium developmental growth involved in morphogenesis hematopoietic progenitor cell differentiation B cell activation involved in immune response positive regulation of immune response positive regulation of isotype switching to IgA isotypes positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response DNA recombination DNA metabolic process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of DNA metabolic process immunoglobulin production positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of immunoglobulin production regulation of isotype switching isotype switching to IgA isotypes somatic diversification of immune receptors via germline recombination within a single locus lymphocyte mediated immunity regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response leukocyte mediated immunity somatic diversification of immune receptors positive regulation of adaptive immune response somatic recombination of immunoglobulin genes involved in immune response regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins regulation of leukocyte mediated immunity regulation of immune response isotype switching immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity regulation of isotype switching to IgA isotypes positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte activation involved in immune response B cell activation immunoglobulin mediated immune response positive regulation of B cell activation regulation of lymphocyte mediated immunity regulation of immunoglobulin production glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process carbohydrate biosynthetic process hyaluronan biosynthetic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process polysaccharide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process cell junction organization cell-cell junction organization cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external biotic stimulus response to virus response to biotic stimulus	extracellular region extracellular space cellular anatomical entity cell surface cell periphery extracellular matrix external encapsulating structure intracellular anatomical structure cytoplasm blood microparticle membrane-bounded organelle intracellular organelle organelle nucleus extracellular region extracellular space cellular anatomical entity cell surface cell periphery extracellular matrix external encapsulating structure intracellular anatomical structure cytoplasm blood microparticle membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013517	FG-GAP repeat	Repeat
A	IPR048286	Integrin alpha, third immunoglobulin-like domain	Domain
A	IPR013649	Integrin alpha, first immunoglubulin-like domain	Domain
A	IPR048285	Integrin alpha, second immunoglobulin-like domain	Domain
A	IPR032695	Integrin domain superfamily	Homologous Superfamily
A	IPR013519	Integrin alpha beta-propellor	Repeat
A	IPR000413	Integrin alpha chain	Family
A	IPR028994	Integrin alpha, N-terminal	Homologous Superfamily
A	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	Conserved Site
B	IPR033760	Integrin beta N-terminal	Domain
B	IPR013111	EGF-like domain, extracellular	Domain
B	IPR015812	Integrin beta subunit	Family
B	IPR002369	Integrin beta subunit, VWA domain	Domain
B	IPR016201	PSI domain	Domain
B	IPR000742	EGF-like domain	Domain
B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B	IPR032695	Integrin domain superfamily	Homologous Superfamily
C [auth D]	IPR003939	Transforming growth factor beta-1 proprotein	Family
C [auth D]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
C [auth D]	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
C [auth D]	IPR001839	Transforming growth factor-beta, C-terminal	Domain
C [auth D]	IPR016319	Transforming growth factor-beta	Family
C [auth D]	IPR015615	Transforming growth factor-beta-related	Family
C [auth D]	IPR001111	TGF-beta, propeptide	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P06756	Acute Cerebrovascular Accidents glioblastoma intracerebral hemorrhage myopathy osteosarcoma rheumatoid arthritis breast cancer cerebrovascular disorder hereditary spastic paraplegia large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer tuberculosis diabetes mellitus inflammatory bowel disease Acute Cerebrovascular Accidents glioblastoma intracerebral hemorrhage myopathy osteosarcoma rheumatoid arthritis breast cancer cerebrovascular disorder hereditary spastic paraplegia large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer tuberculosis diabetes mellitus inflammatory bowel disease medulloblastoma non-small cell lung carcinoma pilocytic astrocytoma
B	Pharos: P26012	inflammatory bowel disease endometriosis pilocytic astrocytoma Prostate cancer, familial spina bifida allergic rhinitis breast cancer lung carcinoma malignant glioma osteosarcoma primary biliary cholangitis prostate carcinoma tuberculosis astrocytic tumor chronic obstructive pulmonary disease inflammatory bowel disease endometriosis pilocytic astrocytoma Prostate cancer, familial spina bifida allergic rhinitis breast cancer lung carcinoma malignant glioma osteosarcoma primary biliary cholangitis prostate carcinoma tuberculosis astrocytic tumor chronic obstructive pulmonary disease large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor psoriasis atypical teratoid rhabdoid tumor cystic fibrosis glioblastoma lung cancer malignant ependymoma oligodendroglioma