The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A [1]. The OapA protein is required for efficient nasopharyngeal mucosal colonization ...
The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A [1]. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1]. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB [3]. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments [3]. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links [4]. The OapA domain is distantly related to Pfam:PF01476.
This entry represents the second domain from the Csd3 peptidase [2]. This domain has a similar structure to Pfam:PF18059 despite low sequence similarity [2].