Annotations: 6U3S

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00226	DnaJ domain (DnaJ)	DnaJ domain	DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are conf ...	DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DnaJ homolog subfamily B member 6	ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity protein binding binding heat shock protein binding Hsp70 protein binding protein-folding chaperone binding DNA binding organic cyclic compound binding nucleic acid binding unfolded protein binding protein folding chaperone ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity protein binding binding heat shock protein binding Hsp70 protein binding protein-folding chaperone binding DNA binding organic cyclic compound binding nucleic acid binding unfolded protein binding protein folding chaperone identical protein binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process regulation of cellular component organization negative regulation of cellular component organization regulation of inclusion body assembly inclusion body assembly regulation of cellular component biogenesis cellular component biogenesis cellular component organization cellular component assembly cellular component organization or biogenesis negative regulation of inclusion body assembly negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein metabolic process negative regulation of protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process negative regulation of programmed cell death regulation of protein metabolic process regulation of apoptotic process regulation of peptidase activity negative regulation of molecular function cell death regulation of molecular function negative regulation of apoptotic process regulation of hydrolase activity negative regulation of cysteine-type endopeptidase activity apoptotic process programmed cell death developmental process extraembryonic membrane development chorion development anatomical structure development protein maturation protein folding cell differentiation involved in embryonic placenta development multicellular organismal process cellular developmental process placenta development reproductive process syncytiotrophoblast cell differentiation involved in labyrinthine layer development chordate embryonic development animal organ development labyrinthine layer development developmental process involved in reproduction embryo development in utero embryonic development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching cell differentiation embryonic organ development chaperone-mediated protein folding extracellular matrix organization extracellular structure organization external encapsulating structure organization organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization embryonic morphogenesis chorio-allantoic fusion embryonic placenta morphogenesis labyrinthine layer morphogenesis anatomical structure morphogenesis cell adhesion cell-cell adhesion protein localization regulation of localization cellular localization regulation of protein localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization intermediate filament organization intermediate filament-based process supramolecular fiber organization intermediate filament cytoskeleton organization protein localization to organelle protein localization to nucleus cellular response to stimulus cellular response to heat regulation of cellular response to heat response to stimulus regulation of cellular response to stress response to heat response to temperature stimulus cellular response to stress regulation of response to stimulus response to stress regulation of response to stress response to abiotic stimulus	membrane cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer membrane cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen perinuclear region of cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001623	DnaJ domain	Domain
A	IPR018253	DnaJ domain, conserved site	Conserved Site
A	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
A	IPR043183	DnaJ homolog subfamily B member 2/6-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O75190	limb-girdle muscular dystrophy autosomal dominant limb-girdle muscular dystrophy type 1D (DNAJB6) arthrogryposis autosomal dominant limb-girdle muscular dystrophy type 1E (DES) esophageal adenocarcinoma muscular disease myopathy tuberculosis astrocytic tumor Congenital myopathy (disorder) exocrine pancreatic carcinoma malignant pancreatic neoplasm muscular dystrophy osteosarcoma distal myopathy limb-girdle muscular dystrophy autosomal dominant limb-girdle muscular dystrophy type 1D (DNAJB6) arthrogryposis autosomal dominant limb-girdle muscular dystrophy type 1E (DES) esophageal adenocarcinoma muscular disease myopathy tuberculosis astrocytic tumor Congenital myopathy (disorder) exocrine pancreatic carcinoma malignant pancreatic neoplasm muscular dystrophy osteosarcoma distal myopathy glioblastoma muscle tissue disease ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.