Annotations: 6U05

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08302	Fungal tRNA ligase phosphodiesterase domain (tRNA_lig_CPD)	Fungal tRNA ligase phosphodiesterase domain	This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity [1]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.	Domain
A	PF08303	tRNA ligase kinase domain (tRNA_lig_kinase)	tRNA ligase kinase domain	This domain is found in fungal tRNA ligases and has kinase activity [1]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	tRNA ligase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ligase activity, forming phosphoric ester bonds RNA ligase (ATP) activity catalytic activity, acting on RNA RNA ligase activity catalytic activity, acting on a nucleic acid catalytic activity ligase activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity phosphoric ester hydrolase activity phosphoric diester hydrolase activity nucleobase-containing compound kinase activity polynucleotide 5'-hydroxyl-kinase activity GTP-dependent polynucleotide 5'-hydroxyl-kinase activity kinase activity transferase activity GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process RNA splicing cellular biosynthetic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process RNA splicing cellular biosynthetic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process tRNA metabolic process tRNA splicing, via endonucleolytic cleavage and ligation organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via endonucleolytic cleavage and ligation tRNA processing organic substance biosynthetic process nucleic acid catabolic process RNA processing macromolecule metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012387	tRNA ligase Trl1, fungi	Family
A	IPR019039	T4 RNA ligase 1-like, N-terminal	Domain
A	IPR015965	tRNA ligase, phosphodiesterase	Domain
A	IPR015966	tRNA ligase, kinase domain, fungi	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.