6TZ8

Crystal structure of Cryptococcus neoformans Calceineurin A, Calcineurin B, and FKBP12 with FK-506

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F	SCOP2 Family	FKBP immunophilin/proline isomerase	8094768	4001062	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	Rotamase-like	8094769	3000622	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Rotamase-like	8094769	3000622	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00149	e6tz8A1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: PF00149	ECOD (1.6)
D	PF00149	e6tz8D1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: PF00149	ECOD (1.6)
B	PF00036	e6tz8B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
B	PF00036,PF13405	e6tz8B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036,PF13405	ECOD (1.6)
E	PF00036	e6tz8E1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
E	PF00036,PF13405	e6tz8E2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036,PF13405	ECOD (1.6)
F	PF00254	e6tz8F1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: PF00254	ECOD (1.6)
C	PF00254	e6tz8C1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: PF00254	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (utative)
D	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (utative)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (utative)
E	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (utative)
F	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (utative)
C	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
B, E	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain
C, F	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Serine/threonine-protein phosphatase 2B catalytic subunit A1	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds myosin phosphatase activity phosphatase activity hydrolase activity catalytic activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds myosin phosphatase activity phosphatase activity hydrolase activity catalytic activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding protein binding calmodulin binding zinc ion binding calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity	protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization positive regulation of protein localization to nucleus biological regulation positive regulation of biological process regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization positive regulation of protein localization to nucleus biological regulation positive regulation of biological process regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization cellular process positive regulation of cellular process cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction calcineurin-mediated signaling regulation of cellular component organization positive regulation of cellular component organization positive regulation of cell division cytoskeleton-dependent cytokinesis regulation of mitotic cytokinetic process positive regulation of mitotic cytokinesis mitotic cytokinetic process mitotic cytokinesis mitotic cell cycle regulation of cell division cellular component biogenesis cellular component organization cellular component assembly regulation of mitotic cytokinesis positive regulation of cytokinesis positive regulation of cell cycle process positive regulation of mitotic cytokinetic process mitotic division septum assembly cell cycle cellular component organization or biogenesis regulation of cell cycle cell cycle process cell septum assembly regulation of cytokinesis regulation of division septum assembly regulation of cell cycle process positive regulation of cellular component biogenesis positive regulation of cell septum assembly cytokinesis regulation of cytokinetic process regulation of cellular component biogenesis regulation of cell septum assembly positive regulation of cell cycle mitotic cell cycle process positive regulation of mitotic division septum assembly positive regulation of division septum assembly cytokinetic process division septum assembly cell division regulation of mitotic division septum assembly developmental process anatomical structure morphogenesis regulation of developmental process anatomical structure development cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis fungal-type cell wall organization or biogenesis cell wall organization or biogenesis regulation of calcium ion transport negative regulation of biological process negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport negative regulation of calcium ion import across plasma membrane calcium ion import into cytosol monoatomic cation transport regulation of calcium ion import regulation of monoatomic ion transport import across plasma membrane inorganic ion transmembrane transport establishment of localization negative regulation of calcium ion import inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport calcium ion import across plasma membrane regulation of calcium ion import across plasma membrane negative regulation of calcium ion transmembrane transport import into cell transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of metal ion transport calcium ion transmembrane import into cytosol regulation of transport inorganic cation import across plasma membrane negative regulation of calcium ion transport inorganic ion import across plasma membrane regulation of monoatomic cation transmembrane transport calcium ion import calcium ion transmembrane transport cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion positive regulation of organelle organization regulation of mitotic actomyosin contractile ring contraction cortical actin cytoskeleton organization actin filament-based process actomyosin structure organization cortical cytoskeleton organization positive regulation of cytoskeleton organization regulation of organelle organization actomyosin contractile ring contraction regulation of cytoskeleton organization regulation of actomyosin contractile ring contraction mitotic actomyosin contractile ring contraction contractile ring contraction actin cytoskeleton organization organelle organization positive regulation of mitotic actomyosin contractile ring contraction actomyosin contractile ring organization cytoskeleton organization	phosphatase complex protein-containing complex catalytic complex calcineurin complex protein serine/threonine phosphatase complex intracellular protein-containing complex contractile ring cell division site intracellular anatomical structure cell cortex cortical cytoskeleton actomyosin contractile ring cellular anatomical entity actin cytoskeleton phosphatase complex protein-containing complex catalytic complex calcineurin complex protein serine/threonine phosphatase complex intracellular protein-containing complex contractile ring cell division site intracellular anatomical structure cell cortex cortical cytoskeleton actomyosin contractile ring cellular anatomical entity actin cytoskeleton mitotic actomyosin contractile ring intracellular organelle cell periphery cytoskeleton organelle intracellular non-membrane-bounded organelle cortical actin cytoskeleton cytoplasm mitotic actomyosin contractile ring, intermediate layer non-membrane-bounded organelle
B, E	Calcineurin subunit B	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity calcium-dependent protein serine/threonine phosphatase regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity	-	phosphatase complex protein-containing complex catalytic complex calcineurin complex protein serine/threonine phosphatase complex intracellular protein-containing complex
C, F	FK506-binding protein 1	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity	-	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A, D	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A, D	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
A, D	IPR043360	PP2B	Family
A, D	IPR041751	PP2B, metallophosphatase domain	Domain
B, E	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B, E	IPR015757	Calcineurin B protein	Family
B, E	IPR002048	EF-hand domain	Domain
B, E	IPR011992	EF-hand domain pair	Homologous Superfamily
C, F	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
C, F	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.