6TUG

Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF09659	e6tugA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
A	PF22206	e6tugA2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
A	PF22208	e6tugA3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
B	PF09659	e6tugB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
B	PF22206	e6tugB2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
B	PF22208	e6tugB3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
C	PF09659	e6tugC1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
C	PF22206	e6tugC2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
C	PF22208	e6tugC3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
D	PF09659	e6tugD1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
D	PF22206	e6tugD2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
D	PF22208	e6tugD3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
E	PF09659	e6tugE1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
E	PF22206	e6tugE2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
E	PF22208	e6tugE3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
F	PF09659	e6tugF1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
F	PF22206	e6tugF2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
F	PF22208	e6tugF3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
G	PF09659	e6tugG1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
G	PF22206	e6tugG2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
G	PF22208	e6tugG3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)
H	PF09659	e6tugH1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF09659	ECOD (1.6)
H	PF22206	e6tugH2	A: alpha bundles	X: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	H: CRISPR/Cas system-associated protein Csm6 6H domain (From Topology)	T: CRISPR/Cas system-associated protein Csm6 6H domain	F: PF22206	ECOD (1.6)
H	PF22208	e6tugH3	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: PF22208	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF09659	CRISPR-associated protein (Cas_Csm6) (Cas_Csm6)	CRISPR-associated protein (Cas_Csm6)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	CRISPR system endoribonuclease Csm6	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-