6TMV

Structure of the chaperonin gp146 from the bacteriophage EL (Pseudomonas aeruginosa) in the apo state

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00118	e6tmvA1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
A	F_UNCLASSIFIED	e6tmvA2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e6tmvA3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00118	e6tmvB1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
B	F_UNCLASSIFIED	e6tmvB2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6tmvB3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00118	e6tmvC3	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
C	F_UNCLASSIFIED	e6tmvC1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6tmvC2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00118	e6tmvD2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
D	F_UNCLASSIFIED	e6tmvD1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6tmvD3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00118	e6tmvE1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
E	F_UNCLASSIFIED	e6tmvE2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e6tmvE3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF00118	e6tmvF3	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
F	F_UNCLASSIFIED	e6tmvF2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e6tmvF1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF00118	e6tmvG3	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
G	F_UNCLASSIFIED	e6tmvG1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e6tmvG2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF00118	e6tmvH3	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
H	F_UNCLASSIFIED	e6tmvH2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
H	F_UNCLASSIFIED	e6tmvH1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
I	PF00118	e6tmvI1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
I	F_UNCLASSIFIED	e6tmvI2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e6tmvI3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
J	PF00118	e6tmvJ1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
J	F_UNCLASSIFIED	e6tmvJ3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
J	F_UNCLASSIFIED	e6tmvJ2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF00118	e6tmvK1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
K	F_UNCLASSIFIED	e6tmvK3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	F_UNCLASSIFIED	e6tmvK2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
L	PF00118	e6tmvL3	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
L	F_UNCLASSIFIED	e6tmvL1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
L	F_UNCLASSIFIED	e6tmvL2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
M	PF00118	e6tmvM2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
M	F_UNCLASSIFIED	e6tmvM3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
M	F_UNCLASSIFIED	e6tmvM1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)
N	PF00118	e6tmvN2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: PF00118	ECOD (1.6)
N	F_UNCLASSIFIED	e6tmvN3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: F_UNCLASSIFIED	ECOD (1.6)
N	F_UNCLASSIFIED	e6tmvN1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	PF00118	TCP-1/cpn60 chaperonin family (Cpn60_TCP1)	TCP-1/cpn60 chaperonin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	Putative GroEL-like chaperonine protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity cation binding metal ion binding protein-folding chaperone binding identical protein binding	protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process chaperone cofactor-dependent protein refolding chaperone-mediated protein folding 'de novo' protein folding 'de novo' post-translational protein folding interleukin-6 production multicellular organismal process regulation of cellular process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus response to organic substance cellular response to topologically incorrect protein response to stimulus cellular response to unfolded protein response to unfolded protein cellular response to chemical stimulus mitochondrial unfolded protein response cellular response to stress response to chemical response to stress response to topologically incorrect protein cellular response to organic substance protein localization establishment of protein localization cellular localization nitrogen compound transport protein transmembrane import into intracellular organelle transport protein targeting localization protein transmembrane transport cellular macromolecule localization mitochondrial transport organic substance transport protein import into mitochondrial intermembrane space establishment of localization mitochondrial transmembrane transport transmembrane transport establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion response to heat response to abiotic stimulus response to temperature stimulus regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of immune system process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation immune system process regulation of leukocyte cell-cell adhesion regulation of lymphocyte activation interferon-alpha production regulation of interferon-alpha production positive regulation of type I interferon production type I interferon production positive regulation of interferon-alpha production regulation of type I interferon production regulation of type II interferon production type II interferon production positive regulation of type II interferon production	protein-containing complex chaperonin ATPase complex intracellular anatomical structure protein folding chaperone complex GroEL-GroES complex cytoplasm cellular anatomical entity cytosol intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR027413	GroEL-like equatorial domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR017998	Chaperone tailless complex polypeptide 1 (TCP-1)	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR027410	TCP-1-like chaperonin intermediate domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR001844	Chaperonin Cpn60/GroEL	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR027409	GroEL-like apical domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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6TMV

Structure of the chaperonin gp146 from the bacteriophage EL (Pseudomonas aeruginosa) in the apo state

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage