6TMJ

Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, rotor-stator model

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth g2]	PF00231	e6tmjg21	A: a/b three-layered sandwiches	X: ATP synthase (F1-ATPase), gamma subunit (From Topology)	H: ATP synthase (F1-ATPase), gamma subunit (From Topology)	T: ATP synthase (F1-ATPase), gamma subunit	F: PF00231	ECOD (1.6)
D [auth d2]	PF02823	e6tmjd21	A: beta sandwiches	X: Epsilon subunit of F1F0-ATP synthase-N	H: Epsilon subunit of F1F0-ATP synthase-N (From Topology)	T: Epsilon subunit of F1F0-ATP synthase-N	F: PF02823	ECOD (1.6)
D [auth d2]	F_UNCLASSIFIED	e6tmjd22	A: alpha bundles	X: Long alpha-hairpin	H: Epsilon subunit of F1F0-ATP synthase C-terminal domain (From Topology)	T: Epsilon subunit of F1F0-ATP synthase C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth e2]	PF04627	e6tmje21	A: extended segments	X: Epsilon subunit of mitochondrial F1F0-ATP synthase (From Topology)	H: Epsilon subunit of mitochondrial F1F0-ATP synthase (From Topology)	T: Epsilon subunit of mitochondrial F1F0-ATP synthase	F: PF04627	ECOD (1.6)
F [auth H2]	PF00137	e6tmjH21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
G [auth I2]	PF00137	e6tmjI21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
H [auth J2]	PF00137	e6tmjJ21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
I [auth K2]	PF00137	e6tmjK21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
J [auth M2]	PF00137	e6tmjM21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
K [auth N2]	PF00137	e6tmjN21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
L [auth O2]	PF00137	e6tmjO21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
M [auth P2]	PF00137	e6tmjP21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
N [auth Q2]	PF00137	e6tmjQ21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
O [auth L2]	PF00137	e6tmjL21	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth g2]	PF00231	ATP synthase (ATP-synt)	ATP synthase	-	Domain
D [auth d2]	PF02823	ATP synthase, Delta/Epsilon chain, beta-sandwich domain (ATP-synt_DE_N)	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensit ...	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	Domain
E [auth e2]	PF04627	Mitochondrial ATP synthase epsilon chain (ATP-synt_Eps)	Mitochondrial ATP synthase epsilon chain	-	Family
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth Q]	ATPTG11	-	-	-
B [auth K]	subunit a	-	-	membrane cellular anatomical entity
C [auth g2]	ATP synthase subunit gamma	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane protein-containing complex ATPase complex catalytic complex proton-transporting ATP synthase complex membrane protein complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1)
D [auth d2]	ATP synthase subunit delta	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	protein-containing complex ATPase complex intracellular anatomical structure catalytic complex proton-transporting ATP synthase complex membrane membrane protein complex cellular anatomical entity proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1)
E [auth e2]	ATP synthase subunit epsilon	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure mitochondrial membrane organelle inner membrane mitochondrion membrane protein complex intracellular organelle organelle envelope proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1) mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure mitochondrial membrane organelle inner membrane mitochondrion membrane protein complex intracellular organelle organelle envelope proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1) mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) mitochondrial protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex inner mitochondrial membrane protein complex organelle mitochondrial envelope cytoplasm organelle membrane
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	subunit c	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity binding lipid binding	ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process nucleoside triphosphate biosynthetic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm protein-containing complex ATPase complex catalytic complex membrane proton-transporting ATP synthase complex membrane protein complex proton-transporting two-sector ATPase complex, proton-transporting domain membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm protein-containing complex ATPase complex catalytic complex membrane proton-transporting ATP synthase complex membrane protein complex proton-transporting two-sector ATPase complex, proton-transporting domain proton-transporting two-sector ATPase complex proton-transporting ATP synthase complex, coupling factor F(o)

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth g2]	IPR023632	ATP synthase, F1 complex, gamma subunit conserved site	Conserved Site
C [auth g2]	IPR000131	ATP synthase, F1 complex, gamma subunit	Family
C [auth g2]	IPR035968	ATP synthase, F1 complex, gamma subunit superfamily	Homologous Superfamily
D [auth d2]	IPR036771	F0F1 ATP synthase delta/epsilon subunit, N-terminal	Homologous Superfamily
D [auth d2]	IPR020546	ATP synthase, F1 complex, delta/epsilon subunit, N-terminal	Domain
D [auth d2]	IPR001469	ATP synthase, F1 complex, delta/epsilon subunit	Family
E [auth e2]	IPR036742	ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial	Homologous Superfamily
E [auth e2]	IPR006721	ATP synthase, F1 complex, epsilon subunit, mitochondrial	Family
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	IPR038662	F1F0 ATP synthase subunit C superfamily	Homologous Superfamily
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	IPR020537	ATP synthase, F0 complex, subunit C, DCCD-binding site	Binding Site
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	IPR000454	ATP synthase, F0 complex, subunit C	Family
F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
B [auth K], C [auth g2], D [auth d2], F [auth H2], G [auth I2] B [auth K], C [auth g2], D [auth d2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	OPM	Transmembrane	Alpha-helical polytopic	Proton or Sodium translocating F-type, V-type and A-type ATPases	V-type and F-type ATPases

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
B [auth K], C [auth g2], D [auth d2], F [auth H2], G [auth I2] B [auth K], C [auth g2], D [auth d2], F [auth H2], G [auth I2], H [auth J2], I [auth K2], J [auth M2], K [auth N2], L [auth O2], M [auth P2], N [auth Q2], O [auth L2]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	F-type ATPase	F₁F_o ATP synthase hexamer, composite model

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.