6TMH

Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, OSCP/F1/c-ring model

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d6tmha3	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
B [auth A]	d6tmha1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
B [auth A]	d6tmha2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
C [auth E]	d6tmhe3	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
C [auth E]	d6tmhe1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
C [auth E]	d6tmhe2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
D [auth C]	d6tmhc3	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
D [auth C]	d6tmhc1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
D [auth C]	d6tmhc2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ], (Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
E [auth B]	d6tmhb3	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
E [auth B]	d6tmhb1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
E [auth B]	d6tmhb2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
F	d6tmhf3	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
F	d6tmhf1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
F	d6tmhf2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
G [auth D]	d6tmhd3	All alpha proteins	Left-handed superhelix	C-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
G [auth D]	d6tmhd1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	N-terminal domain of alpha and beta (or A/B) subunits of rotary ATPases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
G [auth D]	d6tmhd2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)
H [auth g]	d6tmhg_	Alpha and beta proteins (a/b)	Pyruvate kinase C-terminal domain-like	ATP synthase (F1-ATPase), gamma subunit	automated matches	automated matches	(Toxoplasma gondii GT1 ) [TaxId: 507601 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
H [auth g]	SCOP2B Superfamily	ATP synthase gamma subunit-like	8101910	3000451	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	PF02874	e6tmhA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
B [auth A]	PF00306	e6tmhA3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF00306	ECOD (1.6)
B [auth A]	PF00006	e6tmhA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
C [auth E]	PF02874	e6tmhE3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
C [auth E]	PF00306	e6tmhE1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF00306	ECOD (1.6)
C [auth E]	PF00006	e6tmhE2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
D [auth C]	PF02874	e6tmhC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
D [auth C]	PF00306	e6tmhC2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF00306	ECOD (1.6)
D [auth C]	PF00006	e6tmhC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
E [auth B]	PF02874	e6tmhB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
E [auth B]	PF22919	e6tmhB3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
E [auth B]	PF00006	e6tmhB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
F	PF02874	e6tmhF3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
F	PF22919	e6tmhF1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
F	PF00006	e6tmhF2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
G [auth D]	PF02874	e6tmhD3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
G [auth D]	PF22919	e6tmhD1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
G [auth D]	PF00006	e6tmhD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
H [auth g]	PF00231	e6tmhg1	A: a/b three-layered sandwiches	X: ATP synthase (F1-ATPase), gamma subunit (From Topology)	H: ATP synthase (F1-ATPase), gamma subunit (From Topology)	T: ATP synthase (F1-ATPase), gamma subunit	F: PF00231	ECOD (1.6)
I [auth d]	PF02823	e6tmhd2	A: beta sandwiches	X: Epsilon subunit of F1F0-ATP synthase-N	H: Epsilon subunit of F1F0-ATP synthase-N (From Topology)	T: Epsilon subunit of F1F0-ATP synthase-N	F: PF02823	ECOD (1.6)
I [auth d]	F_UNCLASSIFIED	e6tmhd1	A: alpha bundles	X: Long alpha-hairpin	H: Epsilon subunit of F1F0-ATP synthase C-terminal domain (From Topology)	T: Epsilon subunit of F1F0-ATP synthase C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth e]	PF04627	e6tmhe1	A: extended segments	X: Epsilon subunit of mitochondrial F1F0-ATP synthase (From Topology)	H: Epsilon subunit of mitochondrial F1F0-ATP synthase (From Topology)	T: Epsilon subunit of mitochondrial F1F0-ATP synthase	F: PF04627	ECOD (1.6)
K [auth G]	PF00213	e6tmhG1	A: alpha bundles	X: ATPD N-terminal domain-like	H: N-terminal domain of the delta subunit of the F1F0-ATP synthase (From Topology)	T: N-terminal domain of the delta subunit of the F1F0-ATP synthase	F: PF00213	ECOD (1.6)
L [auth H]	PF00137	e6tmhH1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
M [auth I]	PF00137	e6tmhI1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
N [auth J]	PF00137	e6tmhJ1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
O [auth K]	PF00137	e6tmhK1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
P [auth L]	PF00137	e6tmhL1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
Q [auth M]	PF00137	e6tmhM1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
R [auth N]	PF00137	e6tmhN1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
S [auth O]	PF00137	e6tmhO1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
T [auth P]	PF00137	e6tmhP1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
U [auth Q]	PF00137	e6tmhQ1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A], C [auth E], D [auth C]	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
B [auth A], C [auth E], D [auth C]	PF00306	ATP synthase alpha/beta chain, C terminal domain (ATP-synt_ab_C)	ATP synthase alpha/beta chain, C terminal domain	-	Domain
B [auth A], C [auth E], D [auth C]	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
E [auth B], F, G [auth D]	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
E [auth B], F, G [auth D]	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
H [auth g]	PF00231	ATP synthase (ATP-synt)	ATP synthase	-	Domain
I [auth d]	PF02823	ATP synthase, Delta/Epsilon chain, beta-sandwich domain (ATP-synt_DE_N)	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensit ...	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	Domain
J [auth e]	PF04627	Mitochondrial ATP synthase epsilon chain (ATP-synt_Eps)	Mitochondrial ATP synthase epsilon chain	-	Family
K [auth G]	PF00213	ATP synthase delta (OSCP) subunit (OSCP)	ATP synthase delta (OSCP) subunit	-	Family
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth i]	Inhibitor of F1	-	-	-
B [auth A], C [auth E], D [auth C]	ATP synthase subunit alpha,subunit alpha	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding hydrolase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ligase activity	-	protein-containing complex ATPase complex intracellular anatomical structure catalytic complex proton-transporting ATP synthase complex membrane membrane protein complex cellular anatomical entity proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1)
E [auth B], F, G [auth D]	ATP synthase subunit beta	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity ligase activity	-	protein-containing complex ATPase complex intracellular anatomical structure catalytic complex proton-transporting ATP synthase complex membrane membrane protein complex cellular anatomical entity proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1)
H [auth g]	ATP synthase subunit gamma	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane protein-containing complex ATPase complex catalytic complex proton-transporting ATP synthase complex membrane protein complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1)
I [auth d]	ATP synthase subunit delta	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	protein-containing complex ATPase complex intracellular anatomical structure catalytic complex proton-transporting ATP synthase complex membrane membrane protein complex cellular anatomical entity proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1)
J [auth e]	ATP synthase subunit epsilon	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure mitochondrial membrane organelle inner membrane mitochondrion membrane protein complex intracellular organelle organelle envelope proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1) mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure mitochondrial membrane organelle inner membrane mitochondrion membrane protein complex intracellular organelle organelle envelope proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain proton-transporting ATP synthase complex, catalytic core F(1) mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) mitochondrial protein-containing complex catalytic complex proton-transporting ATP synthase complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex inner mitochondrial membrane protein complex organelle mitochondrial envelope cytoplasm organelle membrane
K [auth G]	Oligomycin sensitivity conferring protein (OSCP)	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity ligase activity	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	subunit c	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity binding lipid binding	ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process nucleoside triphosphate biosynthetic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm protein-containing complex ATPase complex catalytic complex membrane proton-transporting ATP synthase complex membrane protein complex proton-transporting two-sector ATPase complex, proton-transporting domain membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm protein-containing complex ATPase complex catalytic complex membrane proton-transporting ATP synthase complex membrane protein complex proton-transporting two-sector ATPase complex, proton-transporting domain proton-transporting two-sector ATPase complex proton-transporting ATP synthase complex, coupling factor F(o)

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A], C [auth E], D [auth C]	IPR038376	ATP synthase, alpha subunit, C-terminal domain superfamily	Homologous Superfamily
B [auth A], C [auth E], D [auth C]	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
B [auth A], C [auth E], D [auth C]	IPR033732	ATP synthase, F1 complex, alpha subunit nucleotide-binding domain	Domain
B [auth A], C [auth E], D [auth C]	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
B [auth A], C [auth E], D [auth C]	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily	Homologous Superfamily
B [auth A], C [auth E], D [auth C]	IPR000793	ATP synthase, alpha subunit, C-terminal	Domain
B [auth A], C [auth E], D [auth C]	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
B [auth A], C [auth E], D [auth C]	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
B [auth A], C [auth E], D [auth C]	IPR005294	ATP synthase, F1 complex, alpha subunit	Family
B [auth A], C [auth E], D [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth B], F, G [auth D]	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
E [auth B], F, G [auth D]	IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal	Homologous Superfamily
E [auth B], F, G [auth D]	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
E [auth B], F, G [auth D]	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
E [auth B], F, G [auth D]	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
E [auth B], F, G [auth D]	IPR003593	AAA+ ATPase domain	Domain
E [auth B], F, G [auth D]	IPR005722	ATP synthase, F1 complex, beta subunit	Family
E [auth B], F, G [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
H [auth g]	IPR023632	ATP synthase, F1 complex, gamma subunit conserved site	Conserved Site
H [auth g]	IPR000131	ATP synthase, F1 complex, gamma subunit	Family
H [auth g]	IPR035968	ATP synthase, F1 complex, gamma subunit superfamily	Homologous Superfamily
I [auth d]	IPR036771	F0F1 ATP synthase delta/epsilon subunit, N-terminal	Homologous Superfamily
I [auth d]	IPR020546	ATP synthase, F1 complex, delta/epsilon subunit, N-terminal	Domain
I [auth d]	IPR001469	ATP synthase, F1 complex, delta/epsilon subunit	Family
J [auth e]	IPR036742	ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial	Homologous Superfamily
J [auth e]	IPR006721	ATP synthase, F1 complex, epsilon subunit, mitochondrial	Family
K [auth G]	IPR000711	ATPase, OSCP/delta subunit	Family
K [auth G]	IPR026015	F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily	Homologous Superfamily
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	IPR038662	F1F0 ATP synthase subunit C superfamily	Homologous Superfamily
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	IPR020537	ATP synthase, F0 complex, subunit C, DCCD-binding site	Binding Site
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	IPR000454	ATP synthase, F0 complex, subunit C	Family
L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
B [auth A], C [auth E], D [auth C], E [auth B], F B [auth A], C [auth E], D [auth C], E [auth B], F, G [auth D], H [auth g], I [auth d], K [auth G], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	OPM	Transmembrane	Alpha-helical polytopic	Proton or Sodium translocating F-type, V-type and A-type ATPases	V-type and F-type ATPases

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
B [auth A], C [auth E], D [auth C], E [auth B], F B [auth A], C [auth E], D [auth C], E [auth B], F, G [auth D], H [auth g], I [auth d], K [auth G], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
B [auth A], C [auth E], D [auth C], E [auth B], F B [auth A], C [auth E], D [auth C], E [auth B], F, G [auth D], H [auth g], I [auth d], K [auth G], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
B [auth A], C [auth E], D [auth C], E [auth B], F B [auth A], C [auth E], D [auth C], E [auth B], F, G [auth D], H [auth g], I [auth d], K [auth G], L [auth H], M [auth I], N [auth J], O [auth K], P [auth L], Q [auth M], R [auth N], S [auth O], T [auth P], U [auth Q]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	F-type ATPase	F₁F_o ATP synthase hexamer, composite model