Annotations: 6TGB

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DOCK alpha-helical domain-like	8054074	3002273	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SH3-domain	8054076	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth D]	PF06920	e6tgbD3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in dedicator of cytokinesis protein 9 (From Topology)	T: Helical domain in dedicator of cytokinesis protein 9	F: PF06920	ECOD (1.6)
C [auth D]	PF20421	e6tgbD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in dedicator of cytokinesis protein 9 (From Topology)	T: Helical domain in dedicator of cytokinesis protein 9	F: PF20421	ECOD (1.6)
C [auth D]	PF20422	e6tgbD2	A: a+b two layers	X: Barrel domain in dedicator of cytokinesis protein 9 (From Topology)	H: Barrel domain in dedicator of cytokinesis protein 9 (From Topology)	T: Barrel domain in dedicator of cytokinesis protein 9	F: PF20422	ECOD (1.6)
B	PF16457	e6tgbB1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF16457	ECOD (1.6)
B	PF04727	e6tgbB2	A: alpha arrays	X: ELMO domain (From Topology)	H: ELMO domain (From Topology)	T: ELMO domain	F: PF04727	ECOD (1.6)
B	PF11841	e6tgbB3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF11841	ECOD (1.6)
B	F_UNCLASSIFIED	e6tgbB4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth D]	PF20421	DHR-2, Lobe C (DHR-2_Lobe_C)	DHR-2, Lobe C	-	Repeat
A, C [auth D]	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
A, C [auth D]	PF06920	DHR-2, Lobe A (DHR-2_Lobe_A)	DHR-2, Lobe A	-	Repeat
A, C [auth D]	PF20422	DHR-2, Lobe B (DHR-2_Lobe_B)	DHR-2, Lobe B	DOCK (dedicator of cytokinesis) proteins are guanine nucleotide exchange factors (GEFs) that activate some small GTPases, such as Rac or Cdc42, by exchanging bound GDP for free GTP to control cell migration, morphogenesis, and phagocytosis. These pro ...	DOCK (dedicator of cytokinesis) proteins are guanine nucleotide exchange factors (GEFs) that activate some small GTPases, such as Rac or Cdc42, by exchanging bound GDP for free GTP to control cell migration, morphogenesis, and phagocytosis. These proteins share a DOCK-type C2 domain (also termed the DOCK-homology region (DHR)-1) at the N-terminal, and the DHR-2 domain (also termed the DOCKER domain) at the C-terminal. DHR-2 is the GEF catalytic domain organised into three lobes A, B and C, with the Rho-family binding site and catalytic centre generated entirely from lobes B and C. This entry represents Lobe B which adopts an unusual architecture of two antiparallel beta sheets disposed in a loosely packed orthogonal arrangement. This lobe changes its position relative to lobe C and the bound GTPase, which suggests that lobe B distinguishes between the switch 1 conformations of Rac1 and Cdc42 [2].	Domain
B	PF04727	ELMO/CED-12 family (ELMO_CED12)	ELMO/CED-12 family	-	Family
B	PF11841	ELMO, armadillo-like helical domain (ELMO_ARM)	ELMO, armadillo-like helical domain	-	Repeat
B	PF16457	Pleckstrin homology domain (PH_12)	Pleckstrin homology domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth D]	Dedicator of cytokinesis protein 2	small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity guanyl-nucleotide exchange factor activity protein-containing complex binding small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity guanyl-nucleotide exchange factor activity protein-containing complex binding signaling receptor binding T cell receptor binding	developmental process thymic T cell selection multicellular organismal process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process cell differentiation developmental process thymic T cell selection multicellular organismal process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process cell differentiation negative thymic T cell selection anatomical structure development T cell differentiation cellular process negative T cell selection T cell selection leukocyte differentiation positive thymic T cell selection positive T cell selection regulation of localization import into cell positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization transport positive regulation of biological process vesicle-mediated transport cellular component organization localization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of biological process regulation of transport biological regulation regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of phagocytosis positive regulation of transport endocytosis organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cell migration cell motility membrane organization cellular localization membrane raft polarization localization within membrane membrane raft localization membrane raft organization membrane raft distribution chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction myoblast fusion cell-cell fusion muscle cell differentiation myotube differentiation muscle structure development syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis syncytium formation striated muscle cell differentiation macropinocytosis pinocytosis immunological synapse formation cell-cell recognition cell recognition establishment of lymphocyte polarity establishment of T cell polarity establishment or maintenance of cell polarity establishment of cell polarity immune response myeloid dendritic cell activation myeloid dendritic cell activation involved in immune response cell activation involved in immune response myeloid leukocyte activation myeloid cell activation involved in immune response immune effector process leukocyte activation involved in immune response cell population proliferation leukocyte proliferation alpha-beta T cell proliferation mononuclear cell proliferation lymphocyte proliferation alpha-beta T cell activation T cell proliferation	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle specific granule
B	Engulfment and cell motility protein 1	SH3 domain binding protein binding binding protein domain specific binding	cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling Rac protein signal transduction biological regulation intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction membrane organization cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling Rac protein signal transduction biological regulation intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination apoptotic process cell death programmed cell death cell motility organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane protein-containing complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth D]	IPR043162	Dedicator of cytokinesis, C-terminal, lobe C	Homologous Superfamily
A, C [auth D]	IPR016024	Armadillo-type fold	Homologous Superfamily
A, C [auth D]	IPR042455	Dedicator of cytokinesis, N-terminal, subdomain 1	Homologous Superfamily
A, C [auth D]	IPR026791	Dedicator of cytokinesis	Family
A, C [auth D]	IPR046773	DOCKER, Lobe C	Domain
A, C [auth D]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, C [auth D]	IPR046770	DOCKER, Lobe B	Domain
A, C [auth D]	IPR027357	DOCKER domain	Domain
A, C [auth D]	IPR046769	DOCKER, Lobe A	Domain
A, C [auth D]	IPR032376	Dedicator of cytokinesis, N-terminal domain	Domain
A, C [auth D]	IPR026799	Dedicator of cytokinesis protein 2, DHR2 domain	Domain
A, C [auth D]	IPR001452	SH3 domain	Domain
A, C [auth D]	IPR035892	C2 domain superfamily	Homologous Superfamily
A, C [auth D]	IPR027007	C2 DOCK-type domain	Domain
A, C [auth D]	IPR043161	Dedicator of cytokinesis, C-terminal, lobe A	Homologous Superfamily
B	IPR001849	Pleckstrin homology domain	Domain
B	IPR006816	ELMO domain	Domain
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR024574	ELMO, armadillo-like helical domain	Domain
B	IPR011989	Armadillo-like helical	Homologous Superfamily
B	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth D]	Pharos: Q92608	DOCK2 deficiency esophageal adenocarcinoma ulcerative colitis bipolar disorder interstitial cystitis lung carcinoma periodontitis prostate carcinoma spina bifida cutaneous lupus erythematosus head and neck cancer invasive ductal breast carcinoma non-small cell lung carcinoma pilocytic astrocytoma psoriasis DOCK2 deficiency esophageal adenocarcinoma ulcerative colitis bipolar disorder interstitial cystitis lung carcinoma periodontitis prostate carcinoma spina bifida cutaneous lupus erythematosus head and neck cancer invasive ductal breast carcinoma non-small cell lung carcinoma pilocytic astrocytoma psoriasis tuberculosis IgA glomerulonephritis lung cancer osteosarcoma Prostate cancer, familial Sjogren syndrome
B	Pharos: Q92556	Stevens-Johnson syndrome esophageal adenocarcinoma primary biliary cholangitis psoriasis Nodular glomerulosclerosis pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma toxic epidermal necrolysis Alzheimer disease celiac disease Hashimoto thyroiditis lung adenocarcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma Stevens-Johnson syndrome esophageal adenocarcinoma primary biliary cholangitis psoriasis Nodular glomerulosclerosis pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma toxic epidermal necrolysis Alzheimer disease celiac disease Hashimoto thyroiditis lung adenocarcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis attention deficit hyperactivity disorder, inattentive type diabetic kidney disease interstitial cystitis lung cancer malignant glioma ovarian cancer Pick disease subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma lung carcinoma malignant mesothelioma