Annotations: 6TC6

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6tc6a2	All alpha proteins	S13-like H2TH domain	S13-like H2TH domain	automated matches	automated matches	(Neisseria meningitidis alpha522 ) [TaxId: 996307 ],	SCOPe (2.08)
A	d6tc6a1	All beta proteins	N-terminal domain of MutM-like DNA repair proteins	N-terminal domain of MutM-like DNA repair proteins	automated matches	automated matches	(Neisseria meningitidis alpha522 ) [TaxId: 996307 ],	SCOPe (2.08)
A	d6tc6a3	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	automated matches	automated matches	(Neisseria meningitidis alpha522 ) [TaxId: 996307 ],	SCOPe (2.08)
B [auth C]	d6tc6c2	All alpha proteins	S13-like H2TH domain	S13-like H2TH domain	automated matches	automated matches	(Neisseria meningitidis alpha522 ) [TaxId: 996307 ],	SCOPe (2.08)
B [auth C]	d6tc6c1	All beta proteins	N-terminal domain of MutM-like DNA repair proteins	N-terminal domain of MutM-like DNA repair proteins	automated matches	automated matches	(Neisseria meningitidis alpha522 ) [TaxId: 996307 ],	SCOPe (2.08)
B [auth C]	d6tc6c3	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	automated matches	automated matches	(Neisseria meningitidis alpha522 ) [TaxId: 996307 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01149	e6tc6A1	A: beta barrels	X: MutM N-terminal domain-like	H: N-terminal domain of MutM-like DNA repair proteins (From Topology)	T: N-terminal domain of MutM-like DNA repair proteins	F: PF01149	ECOD (1.6)
A	PF06831	e6tc6A3	A: alpha arrays	X: HhH/H2TH	H: H2TH (From Topology)	T: H2TH	F: PF06831	ECOD (1.6)
A	PF06827	e6tc6A2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: C-terminal, Zn-finger domain of MutM-like DNA repair proteins (From Topology)	T: C-terminal, Zn-finger domain of MutM-like DNA repair proteins	F: PF06827	ECOD (1.6)
B [auth C]	PF01149	e6tc6C1	A: beta barrels	X: MutM N-terminal domain-like	H: N-terminal domain of MutM-like DNA repair proteins (From Topology)	T: N-terminal domain of MutM-like DNA repair proteins	F: PF01149	ECOD (1.6)
B [auth C]	PF06831	e6tc6C2	A: alpha arrays	X: HhH/H2TH	H: H2TH (From Topology)	T: H2TH	F: PF06831	ECOD (1.6)
B [auth C]	PF06827	e6tc6C3	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: C-terminal, Zn-finger domain of MutM-like DNA repair proteins (From Topology)	T: C-terminal, Zn-finger domain of MutM-like DNA repair proteins	F: PF06827	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF06827	Zinc finger found in FPG and IleRS (zf-FPG_IleRS)	Zinc finger found in FPG and IleRS	This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.	Domain
A, B [auth C]	PF01149	Formamidopyrimidine-DNA glycosylase N-terminal domain (Fapy_DNA_glyco)	Formamidopyrimidine-DNA glycosylase N-terminal domain	Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges [1 ...	Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	Formamidopyrimidine-DNA glycosylase	DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid class I DNA-(apurinic or apyrimidinic site) endonuclease activity lyase activity catalytic activity carbon-oxygen lyase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid class I DNA-(apurinic or apyrimidinic site) endonuclease activity lyase activity catalytic activity carbon-oxygen lyase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on glycosyl bonds oxidized base lesion DNA N-glycosylase activity oxidized purine nucleobase lesion DNA N-glycosylase activity hydrolase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR000214	Zinc finger, DNA glycosylase/AP lyase-type	Domain
A, B [auth C]	IPR035937	MutM-like, N-terminal	Homologous Superfamily
A, B [auth C]	IPR015887	DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site	Binding Site
A, B [auth C]	IPR012319	Formamidopyrimidine-DNA glycosylase, catalytic domain	Domain
A, B [auth C]	IPR020629	Formamidopyrimidine-DNA glycosylase	Family
A, B [auth C]	IPR015886	DNA glycosylase/AP lyase, H2TH DNA-binding	Domain
A, B [auth C]	IPR010663	Zinc finger, FPG/IleRS-type	Domain
A, B [auth C]	IPR010979	Small ribosomal subunit protein uS13-like, H2TH	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.