6SWH

Crystal structure of the ternary complex between the type 1 pilus proteins FimC, FimI and FimA from E. coli

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6swha1	All beta proteins	Immunoglobulin-like beta-sandwich	PapD-like	Pilus chaperone	Periplasmic chaperone FimC	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d6swha2	All beta proteins	C2 domain-like	Periplasmic chaperone C-domain	Periplasmic chaperone C-domain	FimC	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d6swhd1	All beta proteins	Immunoglobulin-like beta-sandwich	PapD-like	Pilus chaperone	Periplasmic chaperone FimC	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d6swhd2	All beta proteins	C2 domain-like	Periplasmic chaperone C-domain	Periplasmic chaperone C-domain	FimC	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d6swhb_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
E	d6swhe_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d6swhc_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
F	d6swhf_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Periplasmic chaperone C-domain	8035665	3000998	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PapD-like	8055315	3002067	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Periplasmic chaperone C-domain	8035665	3000998	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PapD-like	8055315	3002067	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bacterial adhesin-like	8098656	3000723	SCOP2B (2022-06-29)
E	SCOP2 Family	Pilus subunits	8098655	4002034	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	Bacterial adhesin-like	8098656	3000723	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Bacterial adhesin-like	8098074	3000723	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Bacterial adhesin-like	8098074	3000723	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PapD_C	e6swhA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PapD_C	ECOD (1.6)
A	PapD_N	e6swhA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PapD_N	ECOD (1.6)
D	PapD_C	e6swhD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PapD_C	ECOD (1.6)
D	PapD_N	e6swhD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PapD_N	ECOD (1.6)
B	Fimbrial_1	e6swhB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Fimbrial_1	ECOD (1.6)
E	Fimbrial_1	e6swhE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Fimbrial_1	ECOD (1.6)
C	Fimbrial_1	e6swhC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Fimbrial_1	ECOD (1.6)
F	Fimbrial_1	e6swhF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Fimbrial_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF02753	Pili assembly chaperone PapD, C-terminal domain (PapD_C)	Pili assembly chaperone PapD, C-terminal domain	Ig-like beta-sandwich fold. This domain is the C-terminal part of the pilus and flagellar-assembly chaperone protein PapD.	Domain
A, D	PF00345	Pili and flagellar-assembly chaperone, PapD N-terminal domain (PapD_N)	Pili and flagellar-assembly chaperone, PapD N-terminal domain	C2 domain-like beta-sandwich fold. This domain is the n-terminal part of the PapD chaperone protein for pilus and flagellar assembly.	Domain
B, E	PF00419	Fimbrial protein (Fimbrial)	Fimbrial protein	-	Domain
C, F	PF00419	Fimbrial protein (Fimbrial)	Fimbrial protein	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Chaperone protein FimC	protein folding chaperone	cellular component organization cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation cellular component organization cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process	outer membrane-bounded periplasmic space cell envelope periplasmic space cellular anatomical entity
B, E	Fimbrin-like protein FimI	-	cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms cell-substrate adhesion single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation cell adhesion involved in single-species biofilm formation cell adhesion cellular process single-species submerged biofilm formation cellular component biogenesis cellular component organization cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms cell-substrate adhesion single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation cell adhesion involved in single-species biofilm formation cell adhesion cellular process single-species submerged biofilm formation cellular component biogenesis cellular component organization cellular component assembly cell projection organization pilus assembly cellular component organization or biogenesis pilus organization cell projection assembly	pilus cell projection cellular anatomical entity
C, F	Type-1 fimbrial protein, A chain	identical protein binding protein binding binding	cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms cell-substrate adhesion single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation cell adhesion involved in single-species biofilm formation cell adhesion cellular process single-species submerged biofilm formation	pilus cell projection cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR036316	Pili assembly chaperone, C-terminal domain superfamily	Homologous Superfamily
A, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, D	IPR016148	Pili assembly chaperone, C-terminal	Domain
A, D	IPR008962	PapD-like superfamily	Homologous Superfamily
A, D	IPR016147	Pili assembly chaperone, N-terminal	Domain
A, D	IPR001829	Pili assembly chaperone, bacterial	Family
A, D	IPR018046	Pili assembly chaperone, conserved site	Conserved Site
B, E	IPR000259	Fimbrial-type adhesion domain	Domain
B, E	IPR036937	Fimbrial-type adhesion domain superfamily	Homologous Superfamily
B, E	IPR008966	Adhesion domain superfamily	Homologous Superfamily
C, F	IPR000259	Fimbrial-type adhesion domain	Domain
C, F	IPR036937	Fimbrial-type adhesion domain superfamily	Homologous Superfamily
C, F	IPR008966	Adhesion domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.