Annotations: 6SWG

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF11488	Transcriptional regulatory protein LGE1 (Lge1)	Transcriptional regulatory protein LGE1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Periphilin-1	RNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process multicellular organismal process epithelium development keratinization epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic positive regulation of organelle organization cellular component biogenesis regulation of heterochromatin formation regulation of chromatin organization regulation of DNA methylation-dependent heterochromatin formation regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of DNA methylation-dependent heterochromatin formation positive regulation of heterochromatin formation DNA methylation-dependent heterochromatin formation positive regulation of chromatin organization positive regulation of cellular process heterochromatin formation positive regulation of cellular component biogenesis chromosome organization regulation of cellular component biogenesis organelle organization facultative heterochromatin formation protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to heterochromatin	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle nucleus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C	Protein TASOR	protein-containing complex binding chromatin binding binding RNA binding organic cyclic compound binding nucleic acid binding	developmental process multicellular organismal process blastoderm segmentation embryonic pattern specification anterior/posterior axis specification, embryo anterior/posterior pattern specification segmentation pattern specification process embryo development regionalization tripartite regional subdivision embryonic axis specification multicellular organism development anterior/posterior axis specification anatomical structure development developmental process multicellular organismal process blastoderm segmentation embryonic pattern specification anterior/posterior axis specification, embryo anterior/posterior pattern specification segmentation pattern specification process embryo development regionalization tripartite regional subdivision embryonic axis specification multicellular organism development anterior/posterior axis specification anatomical structure development axis specification cellular developmental process embryonic morphogenesis animal organ development mesenchyme development tissue development epithelial to mesenchymal transition gastrulation anatomical structure morphogenesis mesodermal to mesenchymal transition involved in gastrulation cell differentiation cellular process mesenchymal cell differentiation regulation of cellular process negative regulation of biological process viral life cycle negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process single stranded viral RNA replication via double stranded DNA intermediate negative regulation of cellular biosynthetic process organic cyclic compound metabolic process viral genome replication biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process regulation of single stranded viral RNA replication via double stranded DNA intermediate cellular biosynthetic process RNA metabolic process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of viral process viral RNA genome replication viral process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of viral genome replication biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of viral process regulation of viral life cycle negative regulation of biosynthetic process regulation of viral genome replication protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis protein-containing complex organization epigenetic regulation of gene expression gene expression regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic positive regulation of organelle organization cellular component biogenesis regulation of heterochromatin formation regulation of chromatin organization regulation of DNA methylation-dependent heterochromatin formation regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of DNA methylation-dependent heterochromatin formation positive regulation of heterochromatin formation DNA methylation-dependent heterochromatin formation positive regulation of chromatin organization positive regulation of cellular process heterochromatin formation positive regulation of cellular component biogenesis chromosome organization regulation of cellular component biogenesis organelle organization facultative heterochromatin formation protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to heterochromatin	protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR028851	Periphilin-1	Family
C	IPR046432	TASOR	Family
C	IPR022188	TASOR, DUF3715	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8NEY8	juvenile dermatomyositis myopathy Malignant neoplasm of breast ovarian cancer medulloblastoma
C	Pharos: Q9UK61	breast carcinoma lymphoplasmacytic lymphoma ovarian cancer invasive ductal breast carcinoma medulloblastoma psoriasis large cell medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.