6SUS

Crystal structure of RTX domain blocks IV and V of adenylate cyclase toxin from Bordetella pertussis

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF06594	Haemolysin-type calcium binding protein related domain (HCBP_related)	Haemolysin-type calcium binding protein related domain	This family consists of a number of bacteria specific domains which are found in haemolysin-type calcium binding proteins. This family is found in conjunction with Pfam:PF00353 and is often found in multiple copies.	Domain
A	PF00353	RTX calcium-binding nonapeptide repeat (4 copies) (HemolysinCabind)	RTX calcium-binding nonapeptide repeat (4 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Bifunctional hemolysin/adenylate cyclase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding calcium ion binding metal ion binding phosphorus-oxygen lyase activity cyclase activity lyase activity adenylate cyclase activity catalytic activity calcium- and calmodulin-responsive adenylate cyclase activity toxin activity protein binding calmodulin binding passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality ribose phosphate metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process cAMP biosynthetic process cyclic nucleotide metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process organic substance metabolic process positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality ribose phosphate metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process cAMP biosynthetic process cyclic nucleotide metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process cyclic nucleotide biosynthetic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cAMP metabolic process cyclic purine nucleotide metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process purine ribonucleotide metabolic process purine nucleotide biosynthetic process hemolysis in another organism biological process involved in interspecies interaction between organisms cytolysis in another organism disruption of cell in another organism disruption of anatomical structure in another organism cytolysis killing of cells of another organism cell killing	membrane cellular anatomical entity extracellular region host cell plasma membrane host cellular component host cell part host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018504	RTX, pore-forming domain	Domain
A	IPR005165	Anthrax toxin, edema factor, central	Domain
A	IPR010566	Haemolysin-type calcium binding-related	Domain
A	IPR001343	RTX calcium-binding nonapeptide repeat	Repeat
A	IPR035099	Anthrax toxin, edema factor, C-terminal	Homologous Superfamily
A	IPR003995	RTX toxin determinant A	Family
A	IPR037017	Anthrax toxin, edema factor, central domain superfamily	Homologous Superfamily
A	IPR018511	Hemolysin-type calcium-binding conserved site	Conserved Site
A	IPR011049	Serralysin-like metalloprotease, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.