6SSU

Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with co-substrate Glutathione

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01124	e6ssuA1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
B	PF01124	e6ssuB1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)
C	PF01124	e6ssuC1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: PF01124	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01124	MAPEG family (MAPEG)	MAPEG family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Microsomal glutathione S-transferase 2	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity amide binding modified amino acid binding binding ion binding oligopeptide binding anion binding glutathione binding sulfur compound binding small molecule binding peroxidase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity amide binding modified amino acid binding binding ion binding oligopeptide binding anion binding glutathione binding sulfur compound binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups carbon-sulfur lyase activity leukotriene-C4 synthase activity lyase activity identical protein binding protein binding	icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process icosanoid biosynthetic process organic substance biosynthetic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process icosanoid biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process membrane lipid metabolic process lipid catabolic process catabolic process primary metabolic process membrane lipid catabolic process cellular lipid catabolic process cellular catabolic process cellular lipid metabolic process organic substance catabolic process lipid metabolic process glutathione metabolic process organonitrogen compound metabolic process organonitrogen compound biosynthetic process amide biosynthetic process cellular modified amino acid metabolic process sulfur compound biosynthetic process peptide biosynthetic process cellular modified amino acid biosynthetic process glutathione biosynthetic process sulfur compound metabolic process amide metabolic process nonribosomal peptide biosynthetic process peptide metabolic process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response response to organic substance response to organonitrogen compound response to chemical response to nitrogen compound biological process involved in interspecies interaction between organisms response to lipid response to other organism response to oxygen-containing compound response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cell periphery plasma membrane endoplasmic reticulum membrane cellular anatomical entity membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cell periphery plasma membrane endoplasmic reticulum cytoplasm organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein	Family
A, B, C	IPR018295	FLAP/GST2/LTC4S, conserved site	Conserved Site
A, B, C	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily	Homologous Superfamily
A, B, C	IPR001446	5-lipoxygenase-activating protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q99735	acute myeloid leukemia malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm tuberculosis glioblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia interstitial cystitis pancreatic intraductal papillary-mucinous carcinoma subependymal giant cell astrocytoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	MAPEG (Eicosanoid and Glutathione metabolism proteins)	MAPEG family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG)	Microsomal Glutathione Transferase 2(MGST2)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.