Annotations: 6SN1

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10221	Cell cycle and development regulator Mat89Bb (Mat89Bb)	Cell cycle and development regulator Mat89Bb	-	Family
B	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain	-	Domain
B	PF20504	Integrator complex subunit 14, alpha-helical domain (IntS14_C)	Integrator complex subunit 14, alpha-helical domain	This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14) [1], a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. ...	This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14) [1], a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5 [2]. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13 [1].	Domain
B	PF19435	Integrator complex subunit 14, beta-barrel domain (IntS14_b-barrel)	Integrator complex subunit 14, beta-barrel domain	This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This com ...	This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5 [1]. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14 [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Integrator complex subunit 13	-	regulation of biological process sexual reproduction regulation of reproductive process reproductive process fertilization biological regulation regulation of fertilization regulation of mitotic cell cycle regulation of cellular process cellular process cell cycle regulation of cell cycle mitotic cell cycle localization regulation of biological process sexual reproduction regulation of reproductive process reproductive process fertilization biological regulation regulation of fertilization regulation of mitotic cell cycle regulation of cellular process cellular process cell cycle regulation of cell cycle mitotic cell cycle localization centrosome localization microtubule organizing center localization cell division microtubule cytoskeleton organization mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process snRNA metabolic process organic substance metabolic process biosynthetic process snRNA processing organic substance biosynthetic process nucleic acid catabolic process metabolic process macromolecule metabolic process RNA processing protein localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus protein localization to nuclear envelope transcription elongation by RNA polymerase II regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression DNA-templated transcription elongation organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process sperm motility cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement cilium movement cell motility	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
B	Integrator complex subunit 14	-	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process snRNA metabolic process organic substance metabolic process biosynthetic process snRNA processing organic substance biosynthetic process nucleic acid catabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process snRNA metabolic process organic substance metabolic process biosynthetic process snRNA processing organic substance biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression DNA-templated transcription elongation organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019355	Cell cycle regulator Mat89Bb	Family
B	IPR039841	Integrator complex subunit 14	Family
B	IPR046471	Integrator complex subunit 14, C-terminal	Domain
B	IPR045814	Integrator complex subunit 14, beta-barrel domain	Domain
B	IPR002035	von Willebrand factor, type A	Domain
B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NVM9	Chloracne glioblastoma lung cancer nasopharyngeal carcinoma ovarian cancer colorectal cancer Hodgkins lymphoma malignant colon neoplasm non-small cell lung carcinoma plasma cell myeloma dermatomyositis large cell medulloblastoma medulloblastoma osteosarcoma psoriasis
B	Pharos: Q96SY0	atypical teratoid rhabdoid tumor medulloblastoma glioblastoma large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.