6SCT

Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
H [auth F]	PF00637	e6sctF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00637	ECOD (1.6)
I [auth K]	PF00637	e6sctK1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00637	ECOD (1.6)
A	PF00637	e6sctA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00637	ECOD (1.6)
F [auth J]	PF01086	e6sctJ1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: PF01086	ECOD (1.6)
G [auth O]	PF01086	e6sctO1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: PF01086	ECOD (1.6)
E	PF01086	e6sctE1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: PF01086	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	PF00637	Region in Clathrin and VPS (Clathrin)	Region in Clathrin and VPS	-	Repeat
D, E, F [auth J], G [auth O], N [auth I], D, E, F [auth J], G [auth O], N [auth I], O [auth N]	PF09420	Ribosome biogenesis protein Nop16 (Nop16)	Ribosome biogenesis protein Nop16	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	Clathrin heavy chain	clathrin binding protein binding binding clathrin light chain binding structural molecule activity disordered domain specific binding protein domain specific binding	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport vesicle-mediated transport	protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm clathrin coat of coated pit clathrin complex membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle vesicle cytosol vesicle coat transport vesicle membrane clathrin coat of trans-Golgi network vesicle bounding membrane of organelle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle vesicle membrane clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle Golgi apparatus coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane
D, E, F [auth J], G [auth O], N [auth I], D, E, F [auth J], G [auth O], N [auth I], O [auth N]	Clathrin light chain	-	-	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR016341	Clathrin, heavy chain	Family
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR015348	Clathrin, heavy chain, linker, core motif	Domain
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR022365	Clathrin, heavy chain, propeller repeat	Repeat
A, B, C, H [auth F], I [auth K], A, B, C, H [auth F], I [auth K], J [auth G], K [auth L], L [auth H], M	IPR016025	Clathrin heavy chain, N-terminal	Homologous Superfamily
D, E, F [auth J], G [auth O], N [auth I], D, E, F [auth J], G [auth O], N [auth I], O [auth N]	IPR019002	Ribosome biogenesis protein Nop16	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.