6SAK

Structure of the OTULINcat C129A - SNX27 PDZ domain complex.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d6sakd_	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6sakc_	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cysteine proteinases	8056959	3001808	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cysteine proteinases	8056959	3001808	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_C101	e6sakA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C101	ECOD (1.6)
B	Peptidase_C101	e6sakB1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C101	ECOD (1.6)
D	PDZ	e6sakD1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
C	PDZ	e6sakC1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (utative)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16218	Peptidase family C101 (Peptidase_C101)	Peptidase family C101	-	Family
C, D	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ubiquitin thioesterase otulin	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication cellular process signal transduction Wnt signaling pathway protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein linear deubiquitination protein modification by small protein conjugation or removal biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response negative regulation of response to stimulus negative regulation of biological process regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response protein ubiquitination protein modification by small protein conjugation response to organic substance response to cytokine cytokine-mediated signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance regulation of tumor necrosis factor-mediated signaling pathway regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus regulation of response to cytokine stimulus response to chemical response to tumor necrosis factor proteolysis developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis sprouting angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process negative regulation of NF-kappaB transcription factor activity nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process negative regulation of molecular function regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway regulation of innate immune response positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus intracellular receptor signaling pathway positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of innate immune response	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol LUBAC complex protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex
C, D	Sorting nexin-27	binding phospholipid binding lipid binding phosphatidylinositol binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding	regulation of postsynaptic membrane neurotransmitter receptor levels biological regulation regulation of biological quality cellular localization transport endosome to lysosome transport intracellular transport lysosomal transport establishment of localization vesicle-mediated transport localization establishment of localization in cell cellular process vacuolar transport regulation of postsynaptic membrane neurotransmitter receptor levels biological regulation regulation of biological quality cellular localization transport endosome to lysosome transport intracellular transport lysosomal transport establishment of localization vesicle-mediated transport localization establishment of localization in cell cellular process vacuolar transport establishment of lymphocyte polarity multicellular organismal process cell activation establishment or maintenance of cell polarity natural killer cell activation lymphocyte activation leukocyte activation establishment of cell polarity immune system process establishment of natural killer cell polarity cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling signal transduction cell communication protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport endosomal transport localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle synapse cell junction glutamatergic synapse early endosome endosome intracellular vesicle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle synapse cell junction glutamatergic synapse early endosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle cell periphery immunological synapse plasma membrane membrane endosome membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023237	Ubiquitin thioesterase otulin	Family
A, B	IPR023235	FAM105	Family
C, D	IPR037835	SNX27, RA domain	Domain
C, D	IPR001683	Phox homology	Domain
C, D	IPR000159	Ras-associating domain	Domain
C, D	IPR037831	SNX17/27/31-like	Family
C, D	IPR037827	SNX27, atypical FERM-like domain	Domain
C, D	IPR037833	SNX27, PX domain	Domain
C, D	IPR036034	PDZ superfamily	Homologous Superfamily
C, D	IPR036871	PX domain superfamily	Homologous Superfamily
C, D	IPR001478	PDZ domain	Domain
C, D	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96BN8	infantile-onset periodic fever-panniculitis-dermatosis syndrome allergic rhinitis malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma tuberculosis astrocytic tumor intellectual disability oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia diabetes mellitus interstitial cystitis ovarian cancer periodic fever syndrome
C, D	Pharos: Q96L92	attention deficit hyperactivity disorder, inattentive type lung cancer myocardial infarction psoriasis heart disease malignant ependymoma osteosarcoma rheumatoid arthritis large cell medulloblastoma medulloblastoma Pick disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.