6S8B

Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2B Superfamily	CRISPR-associated proteins	8097728	3001554	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CRISPR-associated proteins	8097728	3001554	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	CRISPR-associated proteins	8097728	3001554	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	CRISPR-associated proteins	8097728	3001554	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6s8bA1	A: alpha bundles	X: ATPD N-terminal domain-like	H: Cas Cmr5-like (From Topology)	T: Cas Cmr5-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6s8bB1	A: alpha bundles	X: ATPD N-terminal domain-like	H: Cas Cmr5-like (From Topology)	T: Cas Cmr5-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6s8bC1	A: alpha bundles	X: ATPD N-terminal domain-like	H: Cas Cmr5-like (From Topology)	T: Cas Cmr5-like	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF03787	e6s8bG1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7/Csa2-related	F: PF03787	ECOD (1.6)
D	PF03787	e6s8bD1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7/Csa2-related	F: PF03787	ECOD (1.6)
E	PF03787	e6s8bE1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7/Csa2-related	F: PF03787	ECOD (1.6)
F	PF03787	e6s8bF1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7/Csa2-related	F: PF03787	ECOD (1.6)
H	F_UNCLASSIFIED	e6s8bH2	A: a+b two layers	X: Alpha-beta plaits	H: CRISPR transcript (pre-crRNA) processing endoribonuclease-related (From Topology)	T: CRISPR transcript (pre-crRNA) processing endoribonuclease-related	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF09700	e6s8bH1	A: a+b two layers	X: Alpha-beta plaits	H: CRISPR transcript (pre-crRNA) processing endoribonuclease-related (From Topology)	T: CRISPR transcript (pre-crRNA) processing endoribonuclease-related	F: PF09700	ECOD (1.6)
T [auth S]	PF19021	e6s8bS1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
AA [auth o]	PF19021	e6s8bo1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
BA [auth p]	PF19021	e6s8bp1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
CA [auth q]	PF19021	e6s8bq1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
DA [auth r]	PF19021	e6s8br1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
EA [auth s]	PF19021	e6s8bs1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
FA [auth t]	PF19021	e6s8bt1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
GA [auth w]	PF19021	e6s8bw1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
HA [auth x]	PF19021	e6s8bx1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
M [auth L]	PF19021	e6s8bL1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
N [auth M]	PF19021	e6s8bM1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
O [auth N]	PF19021	e6s8bN1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
P [auth O]	PF19021	e6s8bO1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
Q [auth P]	PF19021	e6s8bP1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
R [auth Q]	PF19021	e6s8bQ1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
S [auth R]	PF19021	e6s8bR1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
U [auth T]	PF19021	e6s8bT1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
V [auth W]	PF19021	e6s8bW1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
W [auth X]	PF19021	e6s8bX1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
X [auth l]	PF19021	e6s8bl1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
Y [auth m]	PF19021	e6s8bm1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)
Z [auth n]	PF19021	e6s8bn1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF19021	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D, E, F, G	PF03787	RAMP superfamily (RAMPs)	RAMP superfamily	-	Family
H	PF09700	CRISPR-associated protein (Cas_Cmr3) (Cas_Cmr3)	CRISPR-associated protein (Cas_Cmr3)	-	Family
I	PF03787	RAMP superfamily (RAMPs)	RAMP superfamily	-	Family
AA [auth o], BA [auth p], CA [auth q], DA [auth r], EA [auth s], AA [auth o], BA [auth p], CA [auth q], DA [auth r], EA [auth s], FA [auth t], GA [auth w], HA [auth x], M [auth L], N [auth M], O [auth N], P [auth O], Q [auth P], R [auth Q], S [auth R], T [auth S], U [auth T], V [auth W], W [auth X], X [auth l], Y [auth m], Z [auth n]	PF19021	CRISPR system CMR subunit Cmr7 1 (Cmr7A)	CRISPR system CMR subunit Cmr7 1	-	Family
IA [auth K]	PF12469	CRISPR-associated protein Cmr2, N-terminal (Cmr2_N)	CRISPR-associated protein Cmr2, N-terminal	This domain family is typically between 101 and 138 amino acids in length and it is found in subunit Crm2 of the CRISPR RNA-Cas protein complex (Cmr complex) [1].	Domain
J	PF03787	RAMP superfamily (RAMPs)	RAMP superfamily	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	CRISPR-associated protein, Cmr5 family	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	intracellular anatomical structure cytoplasm cellular anatomical entity
D, E, F, G	CRISPR-associated RAMP protein, Cmr4 family	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-
H	CRISPR-associated protein, Cmr3 family	-	-	-
I	CRISPR-associated RAMP protein, Cmr6 family	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-
K [auth U]	Cognate target RNA (46-mer)	-	-	-
L [auth V]	crRNA	-	-	-
AA [auth o], BA [auth p], CA [auth q], DA [auth r], EA [auth s], AA [auth o], BA [auth p], CA [auth q], DA [auth r], EA [auth s], FA [auth t], GA [auth w], HA [auth x], M [auth L], N [auth M], O [auth N], P [auth O], Q [auth P], R [auth Q], S [auth R], T [auth S], U [auth T], V [auth W], W [auth X], X [auth l], Y [auth m], Z [auth n]	CRISPR-associated protein Cmrx	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus clearance of foreign intracellular nucleic acids response to biotic stimulus defense response to other organism response to stress CRISPR-cas system response to external biotic stimulus defense response to virus response to virus	-
IA [auth K]	CRISPR-associated protein, Cmr2 family	-	-	membrane cellular anatomical entity
J	Cmr1	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR010160	CRISPR-associated protein, Cmr5	Family
A, B, C	IPR023101	AF1862-like domain superfamily	Homologous Superfamily
D, E, F, G	IPR005537	CRISPR type III-associated protein	Family
D, E, F, G	IPR013410	CRISPR-associated RAMP Cmr4	Family
H	IPR010165	Type III-B CRISPR module-associated protein Cmr3	Family
H	IPR019117	CRISPR-associated protein, Cmr3	Family
I	IPR010172	CRISPR-associated protein, TM1791	Family
I	IPR005537	CRISPR type III-associated protein	Family
AA [auth o], BA [auth p], CA [auth q], DA [auth r], EA [auth s], AA [auth o], BA [auth p], CA [auth q], DA [auth r], EA [auth s], FA [auth t], GA [auth w], HA [auth x], M [auth L], N [auth M], O [auth N], P [auth O], Q [auth P], R [auth Q], S [auth R], T [auth S], U [auth T], V [auth W], W [auth X], X [auth l], Y [auth m], Z [auth n]	IPR043959	CRISPR system CMR subunit Cmr7 1	Family
IA [auth K]	IPR024615	CRISPR-associated protein Cmr2, N-terminal	Domain
IA [auth K]	IPR038242	CRISPR-Cas system, Cmr2 subunit, D1 domain, cysteine cluster	Homologous Superfamily
IA [auth K]	IPR013407	CRISPR-associated protein Cmr2	Family
IA [auth K]	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
J	IPR005537	CRISPR type III-associated protein	Family
J	IPR007522	CRISPR-associated protein TM1795	Family