Annotations: 6S4L

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	POZ domain	8067489	3000894	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	POZ domain	8067489	3000894	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	POZ domain	8067489	3000894	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	POZ domain	8067489	3000894	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	POZ domain	8067489	3000894	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02214	e6s4lA1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF02214	ECOD (1.6)
A	PF20871	e6s4lA2	A: a+b two layers	X: Glucose permease domain IIB-like	H: H1 domain of KCTD12 (From Topology)	T: H1 domain of KCTD12	F: PF20871	ECOD (1.6)
B	PF02214	e6s4lB1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF02214	ECOD (1.6)
B	PF20871	e6s4lB2	A: a+b two layers	X: Glucose permease domain IIB-like	H: H1 domain of KCTD12 (From Topology)	T: H1 domain of KCTD12	F: PF20871	ECOD (1.6)
C	PF02214	e6s4lC1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF02214	ECOD (1.6)
C	PF20871	e6s4lC2	A: a+b two layers	X: Glucose permease domain IIB-like	H: H1 domain of KCTD12 (From Topology)	T: H1 domain of KCTD12	F: PF20871	ECOD (1.6)
D	PF02214	e6s4lD1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF02214	ECOD (1.6)
D	PF20871	e6s4lD2	A: a+b two layers	X: Glucose permease domain IIB-like	H: H1 domain of KCTD12 (From Topology)	T: H1 domain of KCTD12	F: PF20871	ECOD (1.6)
E	PF02214	e6s4lE1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF02214	ECOD (1.6)
E	PF20871	e6s4lE2	A: a+b two layers	X: Glucose permease domain IIB-like	H: H1 domain of KCTD12 (From Topology)	T: H1 domain of KCTD12	F: PF20871	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF20871	BTB/POZ domain-containing protein KCTD1/15, C-terminal domain (KCTD1-15_CTD)	BTB/POZ domain-containing protein KCTD1/15, C-terminal domain	This entry represents the C-terminal domain of BTB/POZ domain-containing proteins 1 and 15 (KCTD1/15), characterised by beta-sheets surrounded by alpha-helices [1]. Structural similarities of the C-terminal domain of KCTD proteins allowed their class ...	This entry represents the C-terminal domain of BTB/POZ domain-containing proteins 1 and 15 (KCTD1/15), characterised by beta-sheets surrounded by alpha-helices [1]. Structural similarities of the C-terminal domain of KCTD proteins allowed their classification in clades and subclades described in [1].	Domain
A, B, C, D, E	PF02214	BTB/POZ domain (BTB_2)	BTB/POZ domain	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homo ...	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	BTB/POZ domain-containing protein KCTD1	transcription factor binding protein binding binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR048595	BTB/POZ domain-containing protein KCTD1/15-like, C-terminal domain	Domain
A, B, C, D, E	IPR003131	Potassium channel tetramerisation-type BTB domain	Domain
A, B, C, D, E	IPR048599	BTB/POZ domain-containing protein KCTD1, BTB/POZ domain	Domain
A, B, C, D, E	IPR000210	BTB/POZ domain	Domain
A, B, C, D, E	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: Q719H9	scalp-ear-nipple syndrome astrocytic tumor cardiac arrest intellectual disability malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor ductal breast carcinoma in situ interstitial cystitis malignant glioma oligodendroglioma pilocytic astrocytoma spina bifida breast carcinoma scalp-ear-nipple syndrome astrocytic tumor cardiac arrest intellectual disability malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor ductal breast carcinoma in situ interstitial cystitis malignant glioma oligodendroglioma pilocytic astrocytoma spina bifida breast carcinoma glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.