6S2U

Structure of the catalytic domain of T. thermophilus Rel in complex with AMP and ppGpp

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13328	e6s2uA1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF13328	ECOD (1.6)
A	PF04607	e6s2uA2	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: PF04607	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13328	HD domain (HD_4)	HD domain	-	Family
A	PF04607	Region found in RelA / SpoT proteins (RelA_SpoT)	Region found in RelA / SpoT proteins	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	(P)ppGpp synthetase I, SpoT/RelA	-	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process guanosine tetraphosphate metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process guanosine tetraphosphate metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003607	HD/PDEase domain	Domain
A	IPR012676	TGS-like	Homologous Superfamily
A	IPR004095	TGS	Domain
A	IPR045865	ACT-like domain	Homologous Superfamily
A	IPR002912	ACT domain	Domain
A	IPR033655	RelA/SpoT, TGS domain	Domain
A	IPR004811	RelA/SpoT family	Family
A	IPR043519	Nucleotidyltransferase superfamily	Homologous Superfamily
A	IPR007685	RelA/SpoT	Domain
A	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
A	IPR045600	RelA/SpoT, AH and RIS domains	Domain
A	IPR006674	HD domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.