6RWK

MxiD N0 N1 and MxiG C-terminal domains of the Shigella type 3 secretion system

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth Y]	UNK_F_TYPE	e6rwkY1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
B [auth Y]	PRK15339	e6rwkY2	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
F [auth 4]	UNK_F_TYPE	e6rwk42	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
F [auth 4]	PRK15339	e6rwk41	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
G [auth 6]	UNK_F_TYPE	e6rwk62	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
G [auth 6]	PRK15339	e6rwk61	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
H [auth 8]	UNK_F_TYPE	e6rwk81	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
H [auth 8]	PRK15339	e6rwk82	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
M [auth 3]	UNK_F_TYPE	e6rwk31	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
M [auth 3]	PRK15339	e6rwk32	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
P [auth 9]	UNK_F_TYPE	e6rwk92	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
P [auth 9]	PRK15339	e6rwk91	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
A [auth X]	UNK_F_TYPE	e6rwkX2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
A [auth X]	PRK15339	e6rwkX1	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
C [auth Z]	UNK_F_TYPE	e6rwkZ1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
C [auth Z]	PRK15339	e6rwkZ2	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
D [auth 0]	UNK_F_TYPE	e6rwk02	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
D [auth 0]	PRK15339	e6rwk01	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
E [auth 2]	UNK_F_TYPE	e6rwk22	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
E [auth 2]	PRK15339	e6rwk21	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
I [auth x]	UNK_F_TYPE	e6rwkx2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
I [auth x]	PRK15339	e6rwkx1	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
J [auth y]	UNK_F_TYPE	e6rwky2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
J [auth y]	PRK15339	e6rwky1	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
K [auth z]	UNK_F_TYPE	e6rwkz1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
K [auth z]	PRK15339	e6rwkz2	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
L [auth 1]	UNK_F_TYPE	e6rwk11	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
L [auth 1]	PRK15339	e6rwk12	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
N [auth 5]	UNK_F_TYPE	e6rwk51	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
N [auth 5]	PRK15339	e6rwk52	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)
O [auth 7]	UNK_F_TYPE	e6rwk71	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Ring-building motif II in type III secretion system (From Topology)	T: Ring-building motif II in type III secretion system	F: UNK_F_TYPE	ECOD (1.6)
O [auth 7]	PRK15339	e6rwk72	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: N0 domain in phage tail proteins and secretins (From Topology)	T: N0 domain in phage tail proteins and secretins	F: PRK15339	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth Y]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
B [auth Y]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
F [auth 4]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
F [auth 4]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
G [auth 6]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
G [auth 6]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
H [auth 8]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
H [auth 8]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
M [auth 3]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
M [auth 3]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
P [auth 9]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
P [auth 9]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
A [auth X]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
A [auth X]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
C [auth Z]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
C [auth Z]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
D [auth 0]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
D [auth 0]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
E [auth 2]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
E [auth 2]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
I [auth x]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
I [auth x]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
J [auth y]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
J [auth y]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
K [auth z]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
K [auth z]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
L [auth 1]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
L [auth 1]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
N [auth 5]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
N [auth 5]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)
O [auth 7]	3.55.50.30	Alpha Beta	3-Layer(bab) Sandwich	Phage tail protein beta-alpha-beta fold		CATH (utative)
O [auth 7]	3.30.1370.120	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	PF03958	Bacterial type II/III secretion system short domain (Secretin_N)	Bacterial type II/III secretion system short domain	This is a short, often repeated, domain found in bacterial type II/III secretory system proteins. All previous NolW-like domains fall into this family.	Domain
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	PF21304	SPI-1 type 3 secretion system secretin, N0 domain (T3S_SPI-1_N0)	SPI-1 type 3 secretion system secretin, N0 domain	SPI-1 type 3 secretion system secretin forms a ring-shaped multimeric structure which is used to inject bacterial effector proteins into eukaryotic host cells [1-3]. It consists of several N-terminal short domains and a C-terminal secretin domain (P ...	SPI-1 type 3 secretion system secretin forms a ring-shaped multimeric structure which is used to inject bacterial effector proteins into eukaryotic host cells [1-3]. It consists of several N-terminal short domains and a C-terminal secretin domain (Pfam:PF00263). This entry represents the N-terminal N0 domain.	Domain
AA [auth H], BA [auth K], CA [auth N], DA [auth Q], EA [auth T], AA [auth H], BA [auth K], CA [auth N], DA [auth Q], EA [auth T], FA [auth V], Q [auth A], R [auth D], S [auth G], T [auth J], U [auth M], V [auth P], W [auth S], X [auth U], Y [auth B], Z [auth E]	PF09480	Type III secretion system protein PrgH-EprH (PrgH) (PrgH)	Type III secretion system protein PrgH-EprH (PrgH)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	Outer membrane protein MxiD	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport protein secretion by the type III secretion system establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport protein secretion by the type III secretion system establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization cellular process	protein-containing complex type III protein secretion system complex cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity
AA [auth H], BA [auth K], CA [auth N], DA [auth Q], EA [auth T], AA [auth H], BA [auth K], CA [auth N], DA [auth Q], EA [auth T], FA [auth V], Q [auth A], R [auth D], S [auth G], T [auth J], U [auth M], V [auth P], W [auth S], X [auth U], Y [auth B], Z [auth E]	Protein MxiG	-	-	cell periphery plasma membrane membrane cellular anatomical entity cell outer membrane external encapsulating structure cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	IPR005644	NolW-like	Domain
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	IPR004846	Type II/III secretion system, secretin-like domain	Domain
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	IPR038591	NolW-like superfamily	Homologous Superfamily
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	IPR003522	Type III secretion system outer membrane pore YscC/HrcC	Family
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	IPR004845	Type II secretion system protein GspD, conserved site	Conserved Site
A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], A [auth X], B [auth Y], C [auth Z], D [auth 0], E [auth 2], F [auth 4], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9]	IPR049034	SPI-1 type 3 secretion system secretin, N0 domain	Domain
AA [auth H], BA [auth K], CA [auth N], DA [auth Q], EA [auth T], AA [auth H], BA [auth K], CA [auth N], DA [auth Q], EA [auth T], FA [auth V], Q [auth A], R [auth D], S [auth G], T [auth J], U [auth M], V [auth P], W [auth S], X [auth U], Y [auth B], Z [auth E]	IPR019029	Type III secretion system, PrgH/EprH-like	Family

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth X], AA [auth H], B [auth Y], BA [auth K], C [auth Z] A [auth X], AA [auth H], B [auth Y], BA [auth K], C [auth Z], CA [auth N], D [auth 0], DA [auth Q], E [auth 2], EA [auth T], F [auth 4], FA [auth V], G [auth 6], H [auth 8], I [auth x], J [auth y], K [auth z], L [auth 1], M [auth 3], N [auth 5], O [auth 7], P [auth 9], Q [auth A], R [auth D], S [auth G], T [auth J], U [auth M], V [auth P], W [auth S], X [auth U], Y [auth B], Z [auth E]	mpstruc	TRANSMEMBRANE PROTEINS: BETA-BARREL	Type III Secretion Systems	Type III secretion system (T3SS): MxiD N0 N1 and MxiG C-terminal domains