6RTF

Structure of murine Solute Carrier 26 family member A9 (Slc26a9) anion transporter in an intermediate state

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleobase/cation symporter 2 NCS2-like	8092946	3002647	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleobase/cation symporter 2 NCS2-like	8092946	3002647	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00916	Sulfate permease family (Sulfate_transp)	Sulfate permease family	-	Family
A, B	PF01740	STAS domain (STAS)	STAS domain	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding ...	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Solute carrier family 26 member 9,Solute carrier family 26 member 9	bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity oxalate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity oxalate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity chloride:bicarbonate antiporter activity monoatomic ion transmembrane transporter activity inorganic anion transmembrane transporter activity solute:inorganic anion antiporter activity sulfate transmembrane transporter activity sulfur compound transmembrane transporter activity monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic anion channel activity chloride channel activity ATPase binding protein binding binding enzyme binding identical protein binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport chemical homeostasis homeostatic process regulation of pH biological regulation monoatomic ion homeostasis monoatomic cation homeostasis regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process bicarbonate transport organic anion transport organic substance transport	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane cell surface membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane cell surface membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane Golgi membrane Golgi apparatus bounding membrane of organelle endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001902	SLC26A/SulP transporter	Family
A, B	IPR002645	STAS domain	Domain
A, B	IPR036513	STAS domain superfamily	Homologous Superfamily
A, B	IPR011547	SLC26A/SulP transporter domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	APC (Amino acid-Polyamine-organoCation) superfamily	Sulfate permease

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier (SLC) Transporter Superfamily	Solute Carrier 26 family member A9 (SLC26A9) anion transporter, inward facing state

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.