Annotations: 6RS2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF00571	e6rs2B1	A: a+b duplicates or obligate multimers	X: CBS-domain (From Topology)	H: CBS-domain (From Topology)	T: CBS-domain	F: PF00571	ECOD (1.6)
B [auth C]	PF00571	e6rs2C1	A: a+b duplicates or obligate multimers	X: CBS-domain (From Topology)	H: CBS-domain (From Topology)	T: CBS-domain	F: PF00571	ECOD (1.6)
C [auth D]	PF00571	e6rs2D1	A: a+b duplicates or obligate multimers	X: CBS-domain (From Topology)	H: CBS-domain (From Topology)	T: CBS-domain	F: PF00571	ECOD (1.6)
D [auth A]	PF00571	e6rs2A1	A: a+b duplicates or obligate multimers	X: CBS-domain (From Topology)	H: CBS-domain (From Topology)	T: CBS-domain	F: PF00571	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.10.580.10	Alpha Beta	Roll	CBS-domain	CBS-domain	CATH (utative)
B [auth C]	3.10.580.10	Alpha Beta	Roll	CBS-domain	CBS-domain	CATH (utative)
C [auth D]	3.10.580.10	Alpha Beta	Roll	CBS-domain	CBS-domain	CATH (utative)
D [auth A]	3.10.580.10	Alpha Beta	Roll	CBS-domain	CBS-domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth C], C [auth D], D [auth A]	PF00571	CBS domain (CBS)	CBS domain	CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands ...	CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth C], C [auth D], D [auth A]	Metal transporter CNNM4	monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity sodium ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity magnesium ion transmembrane transporter activity	magnesium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development magnesium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development anatomical structure morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development manganese ion homeostasis intracellular manganese ion homeostasis cellular homeostasis intracellular monoatomic cation homeostasis intracellular chemical homeostasis intracellular monoatomic ion homeostasis multicellular organismal process sensory perception of light stimulus system process sensory perception nervous system process visual perception localization transport magnesium ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport response to stimulus	cell periphery plasma membrane membrane cellular anatomical entity basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth C], C [auth D], D [auth A]	IPR046342	CBS domain superfamily	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth A]	IPR044751	Ion transporter-like, CBS domain	Domain
A [auth B], B [auth C], C [auth D], D [auth A]	IPR000595	Cyclic nucleotide-binding domain	Domain
A [auth B], B [auth C], C [auth D], D [auth A]	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth A]	IPR045095	Ancient conserved domain protein family	Family
A [auth B], B [auth C], C [auth D], D [auth A]	IPR000644	CBS domain	Domain
A [auth B], B [auth C], C [auth D], D [auth A]	IPR002550	CNNM, transmembrane domain	Domain
A [auth B], B [auth C], C [auth D], D [auth A]	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth C], C [auth D], D [auth A]	Pharos: Q6P4Q7	Jalili syndrome cone-rod dystrophy amelogenesis imperfecta Amaurosis hypertrichosis bipolar disorder retinal degeneration amaurosis-hypertrichosis syndrome breast fibroadenoma invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm retinitis pigmentosa psoriasis ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.