Annotations: 6RLB

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2B Superfamily	Roadblock/LC7 domain-like	8033463	3001810	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Roadblock/LC7 domain-like	8033463	3001810	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	DLC-like	8034979	3000821	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	DLC-like	8034979	3000821	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	DLC-like	8034979	3000821	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	DLC-like	8034979	3000821	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	DLC-like	8034979	3000821	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	DLC-like	8034979	3000821	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	F_UNCLASSIFIED	e6rlbC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00400	e6rlbD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
F	PF05783	e6rlbF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF05783	ECOD (1.6)
G	PF03259	e6rlbG1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF03259	ECOD (1.6)
H	PF03259	e6rlbH1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF03259	ECOD (1.6)
I	PF01221	e6rlbI1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)
J	PF01221	e6rlbJ1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)
K	PF01221	e6rlbK1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)
L	PF01221	e6rlbL1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)
M	PF01221	e6rlbM1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)
N	PF01221	e6rlbN1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
E, F	PF05783	Dynein light intermediate chain (DLIC) (DLIC)	Dynein light intermediate chain (DLIC)	-	Family
G, H	PF03259	Roadblock/LC7 domain (Robl_LC7)	Roadblock/LC7 domain	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is pro ...	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	Domain
I, J, K, L, M I, J, K, L, M, N	PF01221	Dynein light chain type 1 (Dynein_light)	Dynein light chain type 1	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding dynein light intermediate chain binding protein binding microtubule motor activity cytoskeletal motor activity minus-end-directed microtubule motor activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity dynein intermediate chain binding DNA binding nucleic acid binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups S-methyltransferase activity protein methyltransferase activity methylated-DNA-[protein]-cysteine S-methyltransferase activity transferase activity methyltransferase activity cation binding metal ion binding	cellular component organization organelle organization cellular process cellular component organization or biogenesis microtubule-based movement microtubule-based process cell projection organization cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process cellular component organization organelle organization cellular process cellular component organization or biogenesis microtubule-based movement microtubule-based process cell projection organization cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair DNA modification macromolecule modification methylation	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection cell periphery plasma membrane membrane intracellular anatomical structure cytoplasm protein-containing complex catalytic complex dynein complex membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection cell periphery plasma membrane membrane intracellular anatomical structure cytoplasm protein-containing complex catalytic complex dynein complex intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex nucleus intracellular membrane-bounded organelle
C	WD repeat-containing protein 60	protein binding binding dynein heavy chain binding dynein light chain binding	embryonic organ morphogenesis developmental process multicellular organismal process chordate embryonic development embryonic morphogenesis animal organ development embryo development multicellular organism development anatomical structure morphogenesis embryo development ending in birth or egg hatching skeletal system development anatomical structure development animal organ morphogenesis embryonic skeletal system development embryonic organ morphogenesis developmental process multicellular organismal process chordate embryonic development embryonic morphogenesis animal organ development embryo development multicellular organism development anatomical structure morphogenesis embryo development ending in birth or egg hatching skeletal system development anatomical structure development animal organ morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis system development cellular localization plasma membrane bounded cell projection organization cell projection organization transport intracellular transport intraciliary retrograde transport establishment of localization protein-containing complex localization cellular component organization localization organelle organization establishment of localization in cell microtubule-based transport cellular process transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process cellular component organization or biogenesis cilium organization intraciliary transport organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cell projection assembly	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle pericentriolar material ciliary tip cytoplasm ciliary base extracellular region extracellular space protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex
D	WD repeat-containing protein 34	protein binding binding dynein heavy chain binding dynein light chain binding	cellular localization plasma membrane bounded cell projection organization cell projection organization transport intracellular transport establishment of localization protein-containing complex localization cellular component organization localization organelle organization establishment of localization in cell microtubule-based transport cellular process transport along microtubule cellular localization plasma membrane bounded cell projection organization cell projection organization transport intracellular transport establishment of localization protein-containing complex localization cellular component organization localization organelle organization establishment of localization in cell microtubule-based transport cellular process transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process cellular component organization or biogenesis cilium organization intraciliary transport intraciliary retrograde transport organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cell projection assembly	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure axoneme ciliary plasm cytoplasmic region plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure axoneme ciliary plasm cytoplasmic region plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle cytoplasm non-membrane-bounded organelle centrosome microtubule organizing center microtubule cytoskeleton centriole cytosol ciliary tip protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex ciliary basal body actin-based cell projection filopodium
E, F	Cytoplasmic dynein 2 light intermediate chain 1	protein binding binding dynein heavy chain binding	developmental process multicellular organism development multicellular organismal process determination of bilateral symmetry anatomical structure development pattern specification process determination of left/right symmetry left/right pattern formation regionalization specification of symmetry regulation of cellular process regulation of cellular component organization cell projection organization plasma membrane bounded cell projection assembly developmental process multicellular organism development multicellular organismal process determination of bilateral symmetry anatomical structure development pattern specification process determination of left/right symmetry left/right pattern formation regionalization specification of symmetry regulation of cellular process regulation of cellular component organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization cellular component assembly cilium assembly cellular component organization or biogenesis cilium organization regulation of biological process organelle assembly plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of organelle organization regulation of plasma membrane bounded cell projection assembly regulation of cilium assembly organelle organization regulation of organelle assembly cellular process cell projection assembly regulation of plasma membrane bounded cell projection organization cellular localization transport localization establishment of localization in cell transport along microtubule intraciliary transport intraciliary transport involved in cilium assembly intracellular transport establishment of localization protein-containing complex localization microtubule-based transport cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process intraciliary retrograde transport	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure axoneme ciliary plasm cytoplasmic region plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure axoneme ciliary plasm cytoplasmic region plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle cytoplasm non-membrane-bounded organelle apical part of cell Golgi apparatus intracellular membrane-bounded organelle endomembrane system ciliary transition zone centrosome microtubule organizing center microtubule cytoskeleton cytosol ciliary tip motile cilium protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex ciliary basal body polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
G, H	Dynein light chain roadblock-type 1	microtubule motor activity cytoskeletal motor activity ATP-dependent activity protein binding binding dynein intermediate chain binding	microtubule-based movement microtubule-based process cellular process response to light stimulus behavior multicellular organismal process response to stimulus visual behavior response to radiation response to abiotic stimulus	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle ciliary tip cytoplasm protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
I, J, K, L, M I, J, K, L, M, N	Dynein light chain 1, cytoplasmic	protein binding binding protein domain specific binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity scaffold protein binding protein-containing complex binding nitric-oxide synthase regulator activity dynein intermediate chain binding enzyme binding identical protein binding	organelle assembly plasma membrane bounded cell projection organization motile cilium assembly cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis cilium organization cell projection assembly organelle assembly plasma membrane bounded cell projection organization motile cilium assembly cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis cilium organization cell projection assembly regulation of mitochondrial membrane potential biological regulation regulation of biological quality regulation of membrane potential establishment of organelle localization mitochondrion distribution transport mitocytosis establishment of mitochondrion localization export from cell establishment of localization localization mitochondrion localization organelle localization migracytosis mitochondrion organization apoptotic process cell death programmed cell death regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process negative regulation of metabolic process negative regulation of biological process negative regulation of nitric oxide metabolic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process biosynthetic process negative regulation of nitric oxide biosynthetic process negative regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of metabolic process positive regulation of organelle organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of non-motile cilium assembly positive regulation of cell projection organization positive regulation of cellular process regulation of non-motile cilium assembly positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of organelle organization regulation of plasma membrane bounded cell projection assembly positive regulation of cilium assembly regulation of cilium assembly regulation of organelle assembly non-motile cilium assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of organelle assembly cellular localization intracellular transport intraciliary retrograde transport protein-containing complex localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process intraciliary transport phosphorylation cellular metabolic process negative regulation of phosphate metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of phosphorus metabolic process negative regulation of cellular process regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation phosphorus metabolic process developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation anatomical structure development germ cell development protein localization cellular response to stimulus positive regulation of cell communication regulation of localization establishment of protein localization response to organic substance nitrogen compound transport response to stimulus positive regulation of establishment of protein localization cell communication carbohydrate homeostasis cellular macromolecule localization positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels organic substance transport positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose response to chemical glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling homeostatic process positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance positive regulation of peptide secretion regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion positive regulation of signaling multicellular organismal process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development neural nucleus development system development	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cell projection cilium plasma membrane bounded cell projection tertiary granule membrane membrane intracellular vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cell projection cilium plasma membrane bounded cell projection tertiary granule membrane membrane intracellular vesicle endomembrane system tertiary granule cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle vesicle organelle membrane secretory granule membrane centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytosol ciliary tip cell periphery plasma membrane mitotic spindle spindle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome ficolin-1-rich granule membrane ficolin-1-rich granule protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer nucleus neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR026983	Dynein heavy chain	Family
A, B	IPR013602	Dynein heavy chain, linker	Domain
A, B	IPR035706	Dynein heavy chain, ATP-binding dynein motor region	Domain
A, B	IPR041228	Dynein heavy chain, C-terminal domain	Domain
A, B	IPR003593	AAA+ ATPase domain	Domain
A, B	IPR041658	Dynein heavy chain AAA lid domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR042228	Dynein heavy chain, linker, subdomain 3	Homologous Superfamily
A, B	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Domain
A, B	IPR042219	Dynein heavy chain AAA lid domain superfamily	Homologous Superfamily
A, B	IPR024743	Dynein heavy chain, coiled coil stalk	Domain
A, B	IPR013594	Dynein heavy chain, tail	Domain
A, B	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain	Homologous Superfamily
A, B	IPR042222	Dynein heavy chain, domain 2, N-terminal	Homologous Superfamily
A, B	IPR049400	Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain	Domain
A, B	IPR043160	Dynein heavy chain, C-terminal domain, barrel region	Homologous Superfamily
A, B	IPR004273	Dynein heavy chain region D6 P-loop domain	Domain
A, B	IPR024317	Dynein heavy chain, AAA module D4	Domain
A, B	IPR008332	Methylguanine DNA methyltransferase, ribonuclease-like domain	Domain
A, B	IPR036217	Methylated DNA-protein cysteine methyltransferase, DNA binding domain	Homologous Superfamily
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036631	Methylated DNA-protein cysteine methyltransferase domain superfamily	Homologous Superfamily
A, B	IPR014048	Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding	Domain
A, B	IPR001497	Methylated-DNA-[protein]-cysteine S-methyltransferase, active site	Active Site
C	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
C	IPR001680	WD40 repeat	Repeat
C	IPR042505	Cytoplasmic dynein 2 intermediate chain 1	Family
C	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
D	IPR001680	WD40 repeat	Repeat
D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
E, F	IPR022780	Dynein family light intermediate chain	Family
E, F	IPR040045	Cytoplasmic dynein 2 light intermediate chain 1	Family
E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G, H	IPR016561	Dynein light chain roadblock-type 1/2	Family
G, H	IPR004942	Roadblock/LAMTOR2 domain	Domain
I, J, K, L, M I, J, K, L, M, N	IPR037177	Dynein light chain superfamily	Homologous Superfamily
I, J, K, L, M I, J, K, L, M, N	IPR019763	Dynein light chain, type 1/2, conserved site	Conserved Site
I, J, K, L, M I, J, K, L, M, N	IPR001372	Dynein light chain, type 1/2	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: Q8WVS4	Jeune syndrome short-rib thoracic dysplasia 8 with or without polydactyly short rib-polydactyly syndrome short rib-polydactyly syndrome, Verma-Naumoff type asphyxiating thoracic dystrophy 3 intellectual disability malignant ependymoma swine influenza Ciliopathies polydactyly degenerative myopia
D	Pharos: Q96EX3	Jeune syndrome short-rib thoracic dysplasia 11 with or without polydactyly short rib-polydactyly syndrome short rib-polydactyly syndrome, Verma-Naumoff type allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma osteosarcoma primitive neuroectodermal tumor asphyxiating thoracic dystrophy 3 Ciliopathies intellectual disability large cell medulloblastoma malignant glioma Jeune syndrome short-rib thoracic dysplasia 11 with or without polydactyly short rib-polydactyly syndrome short rib-polydactyly syndrome, Verma-Naumoff type allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma osteosarcoma primitive neuroectodermal tumor asphyxiating thoracic dystrophy 3 Ciliopathies intellectual disability large cell medulloblastoma malignant glioma ovarian cancer atopic eczema ductal breast carcinoma in situ invasive ductal breast carcinoma medulloblastoma polydactyly
E, F	Pharos: Q8TCX1	Jeune syndrome short-rib thoracic dysplasia 15 with polydactyly Ellis-van Creveld syndrome short rib-polydactyly syndrome cholelithiasis gallbladder disease osteosarcoma Pick disease psoriasis Ciliopathies heart disease ovarian cancer polydactyly sinusitis interstitial cystitis Jeune syndrome short-rib thoracic dysplasia 15 with polydactyly Ellis-van Creveld syndrome short rib-polydactyly syndrome cholelithiasis gallbladder disease osteosarcoma Pick disease psoriasis Ciliopathies heart disease ovarian cancer polydactyly sinusitis interstitial cystitis malignant ependymoma pancreatitis progressive supranuclear palsy
G, H	Pharos: Q9NP97	melanoma pancreatic intraductal papillary-mucinous neoplasm osteosarcoma plasma cell myeloma ovarian cancer psoriasis
I, J, K, L, M I, J, K, L, M, N	Pharos: P63167	brain ischemia acute myeloid leukemia breast cancer Emery-Dreifuss muscular dystrophy lung cancer ovarian cancer Becker muscular dystrophy Cerebral Ischemia hepatocellular carcinoma lymphoplasmacytic lymphoma plasma cell myeloma Duchenne muscular dystrophy juvenile dermatomyositis myopathy tuberculosis