6QSZ

Crystal structure of the Sir4 H-BRCT domain in complex with Esc1 pS1450 peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6qszA1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6qszC1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e6qszE1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e6qszG1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e6qszI1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	F_UNCLASSIFIED	e6qszK1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
M	F_UNCLASSIFIED	e6qszM1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)
O	F_UNCLASSIFIED	e6qszO1	A: a/b three-layered sandwiches	X: BRCT domain (From Topology)	H: BRCT domain (From Topology)	T: BRCT domain	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O	Regulatory protein SIR4	DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding molecular adaptor activity protein-containing complex binding chromatin binding nucleosome binding	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization establishment of protein-containing complex localization to telomere cellular macromolecule localization macromolecule localization cellular process establishment of localization protein-containing complex localization subtelomeric heterochromatin formation regulation of cellular process localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization cellular localization establishment of protein-containing complex localization to telomere cellular macromolecule localization macromolecule localization cellular process establishment of localization protein-containing complex localization subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process silent mating-type cassette heterochromatin formation cellular response to stimulus double-strand break repair response to stimulus double-strand break repair via nonhomologous end joining primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process cellular response to stress DNA damage response response to stress DNA repair positive regulation of organelle organization cellular component biogenesis regulation of heterochromatin formation regulation of chromatin organization regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of heterochromatin formation positive regulation of chromatin organization positive regulation of cellular process positive regulation of cellular component biogenesis regulation of cellular component biogenesis	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle chromatin silencing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle chromatin silencing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle
B, D, F, H, J B, D, F, H, J, L, N, P	Silent chromatin protein ESC1	-	localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen intracellular non-membrane-bounded organelle chromosome membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O	IPR031556	Sir4, SID domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR001611	Leucine-rich repeat	Repeat

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, C, E, G, I A, C, E, G, I, K, M, O	MSE	Parent Component: MET
B, D, F, H, J B, D, F, H, J, L, N, P	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.