Annotations: 6QLF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	F_UNCLASSIFIED	e6qlfL1	A: a+b two layers	X: Recombination-associated protein rdgC (From Topology)	H: Recombination-associated protein rdgC (From Topology)	T: Recombination-associated protein rdgC	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth O]	F_UNCLASSIFIED	e6qlfO1	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth O]	PF09496	e6qlfO2	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF09496	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth N]	PF05238	Kinetochore protein CHL4 like (CENP-N)	Kinetochore protein CHL4 like	-	Family
C [auth O]	PF09496	Cenp-O kinetochore centromere component (CENP-O)	Cenp-O kinetochore centromere component	-	Family
F [auth U]	PF20994	CENPU protein (CENPU)	CENPU protein	-	Family
H [auth Z]	PF09447	Cnl2/NKP2 family protein (Cnl2_NKP2)	Cnl2/NKP2 family protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L]	Inner kinetochore subunit IML3	-	chromosome organization sister chromatid cohesion cellular component organization organelle organization establishment of meiotic sister chromatid cohesion establishment of sister chromatid cohesion cellular process cellular component organization or biogenesis cell cycle cell cycle process meiotic sister chromatid cohesion developmental process sexual sporulation resulting in formation of a cellular spore sexual reproduction chromosome organization sister chromatid cohesion cellular component organization organelle organization establishment of meiotic sister chromatid cohesion establishment of sister chromatid cohesion cellular process cellular component organization or biogenesis cell cycle cell cycle process meiotic sister chromatid cohesion developmental process sexual sporulation resulting in formation of a cellular spore sexual reproduction cellular developmental process reproductive process reproductive process in single-celled organism meiotic cell cycle cell development developmental process involved in reproduction meiotic cell cycle process sporulation resulting in formation of a cellular spore anatomical structure morphogenesis ascospore formation sexual sporulation cell differentiation anatomical structure formation involved in morphogenesis anatomical structure development sporulation maintenance of meiotic sister chromatid cohesion maintenance of sister chromatid cohesion establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation establishment of chromosome localization chromosome segregation mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion mitotic cell cycle mitotic cell cycle process cell division meiotic chromosome segregation organelle fission sister chromatid segregation meiosis II cell cycle process chromosome organization involved in meiotic cell cycle nuclear division meiotic sister chromatid segregation meiotic nuclear division meiosis II protein localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-containing complex intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-containing complex outer kinetochore membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth N]	Inner kinetochore subunit CHL4	structural molecule activity	protein-containing complex organization chromosome organization protein-DNA complex assembly CENP-A containing chromatin assembly cellular component organization cellular component biogenesis protein-DNA complex organization organelle organization cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis protein-containing complex organization chromosome organization protein-DNA complex assembly CENP-A containing chromatin assembly cellular component organization cellular component biogenesis protein-DNA complex organization organelle organization cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis centromere complex assembly chromatin remodeling at centromere maintenance of meiotic sister chromatid cohesion sister chromatid cohesion maintenance of sister chromatid cohesion cell cycle cell cycle process meiotic sister chromatid cohesion establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation establishment of chromosome localization chromosome segregation organelle assembly non-membrane-bounded organelle assembly kinetochore assembly kinetochore organization cell division protein localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization establishment of meiotic sister chromatid cohesion establishment of sister chromatid cohesion cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition regulation of cell cycle negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission biological regulation negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition sexual reproduction reproductive process meiotic cell cycle mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-containing complex intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-containing complex outer kinetochore membrane-bounded organelle nucleus intracellular membrane-bounded organelle
C [auth O]	Inner kinetochore subunit MCM21	-	negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination regulation of cellular process homologous recombination regulation of reproductive process negative regulation of biological process meiotic DNA double-strand break formation involved in reciprocal meiotic recombination negative regulation of cell cycle regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of meiotic DNA double-strand break formation negative regulation of nucleobase-containing compound metabolic process cell cycle regulation of nucleobase-containing compound metabolic process reciprocal homologous recombination negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination regulation of cellular process homologous recombination regulation of reproductive process negative regulation of biological process meiotic DNA double-strand break formation involved in reciprocal meiotic recombination negative regulation of cell cycle regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of meiotic DNA double-strand break formation negative regulation of nucleobase-containing compound metabolic process cell cycle regulation of nucleobase-containing compound metabolic process reciprocal homologous recombination regulation of biological process regulation of cell cycle process DNA recombination meiotic cell cycle negative regulation of metabolic process primary metabolic process DNA metabolic process reciprocal meiotic recombination organic cyclic compound metabolic process meiotic DNA double-strand break formation meiosis I cell cycle process metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process sexual reproduction reproductive process meiotic cell cycle process cellular component organization organic substance metabolic process regulation of meiotic DNA double-strand break formation meiosis I negative regulation of cellular process meiotic nuclear division cellular component organization or biogenesis regulation of cell cycle cell cycle process negative regulation of macromolecule metabolic process regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination organelle fission biological regulation regulation of macromolecule metabolic process negative regulation of cell cycle process nucleic acid metabolic process nuclear division organelle organization negative regulation of reproductive process cellular process negative regulation of DNA metabolic process establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation establishment of chromosome localization chromosome segregation mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion mitotic cell cycle mitotic cell cycle process establishment of sister chromatid cohesion cell division protein-containing complex organization protein-DNA complex assembly cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly centromere complex assembly protein localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle protein-containing complex COMA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular organelle lumen intracellular membrane-bounded organelle organelle lumen nuclear lumen
D [auth P]	Inner kinetochore subunit CTF19	-	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction cell cycle mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis regulation of cell cycle negative regulation of chromosome separation cell cycle process mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission biological regulation chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of chromosome localization sexual reproduction reproductive process meiotic cell cycle mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion sister chromatid cohesion establishment of sister chromatid cohesion cell division protein localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle protein-containing complex COMA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular organelle lumen intracellular membrane-bounded organelle organelle lumen nuclear lumen
E [auth Q]	Inner kinetochore subunit OKP1	-	establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation cell cycle process sexual reproduction reproductive process meiotic cell cycle cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle protein-containing complex COMA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular organelle lumen intracellular membrane-bounded organelle organelle lumen nuclear lumen
F [auth U]	Inner kinetochore subunit AME1	-	establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation cell cycle process sexual reproduction reproductive process meiotic cell cycle protein localization protein localization to chromosome, centromeric region protein localization to kinetochore protein localization to chromosome protein localization to condensed chromosome protein localization to organelle cellular macromolecule localization macromolecule localization cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle cytoplasm intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle cytoplasm membrane-bounded organelle protein-containing complex COMA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome intracellular organelle lumen intracellular membrane-bounded organelle organelle lumen nuclear lumen microtubule organizing center cytoskeleton spindle pole body microtubule cytoskeleton
G [auth Y]	Inner kinetochore subunit NKP1	-	establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation cell cycle process sexual reproduction reproductive process meiotic cell cycle cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
H [auth Z]	Inner kinetochore subunit NKP2	-	establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation cell cycle process sexual reproduction reproductive process meiotic cell cycle cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-containing complex intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-containing complex inner kinetochore Mis6-Sim4 complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth N]	IPR007902	Centromere protein Chl4/mis15/CENP-N	Family
C [auth O]	IPR018464	Centromere protein O	Family
F [auth U]	IPR048743	Inner kinetochore subunit AME1	Family
H [auth Z]	IPR018565	Kinetochore subunit Nkp2/Cnl2	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.