6QKZ

Full length GluA1/2-gamma8 complex

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyType 2 solute binding protein-like8036483 3000083 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyType 2 solute binding protein-like8036483 3000083 SCOP2B (2022-06-29)
E [auth I]SCOP2 FamilyCACNG1-like8094097 4006459 SCOP2 (2022-06-29)
E [auth I]SCOP2 SuperfamilyClaudin-like8094098 3002606 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF00060e6qkzA3 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: PF00060ECOD (1.6)
APF01094e6qkzA4 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
AF_UNCLASSIFIEDe6qkzA1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
APF10613e6qkzA5 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
CPF00060e6qkzC2 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: PF00060ECOD (1.6)
CPF01094e6qkzC4 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
CF_UNCLASSIFIEDe6qkzC5 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
CPF10613e6qkzC3 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
BPF00060e6qkzB4 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: PF00060ECOD (1.6)
BPF01094e6qkzB5 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
BF_UNCLASSIFIEDe6qkzB1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
BPF10613e6qkzB2 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
DPF00060e6qkzD2 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: PF00060ECOD (1.6)
DPF01094e6qkzD1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: PF01094ECOD (1.6)
DF_UNCLASSIFIEDe6qkzD4 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: F_UNCLASSIFIEDECOD (1.6)
DPF10613e6qkzD5 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: PF10613ECOD (1.6)
E [auth I]PF00822e6qkzI1 A: alpha bundlesX: Bromodomain-likeH: Claudin (From Topology)T: ClaudinF: PF00822ECOD (1.6)
F [auth J]PF00822e6qkzJ1 A: alpha bundlesX: Bromodomain-likeH: Claudin (From Topology)T: ClaudinF: PF00822ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
A, C
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
A, C
PF00497Bacterial extracellular solute-binding proteins, family 3 (SBP_bac_3)Bacterial extracellular solute-binding proteins, family 3This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. Th ...This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1].
Domain
B, D
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
B, D
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
B, D
PF00497Bacterial extracellular solute-binding proteins, family 3 (SBP_bac_3)Bacterial extracellular solute-binding proteins, family 3This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. Th ...This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1].
Domain
E [auth I],
F [auth J]		PF00822PMP-22/EMP/MP20/Claudin family (PMP22_Claudin)PMP-22/EMP/MP20/Claudin family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
GluA1
B, D
Glutamate receptor 2
E [auth I],
F [auth J]		Voltage-dependent calcium channel gamma-8 subunit

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C
IPR001638Solute-binding protein family 3/N-terminal domain of MltFDomain
A, C
IPR028082Periplasmic binding protein-like IHomologous Superfamily
A, C
IPR001828Receptor, ligand binding regionDomain
A, C
IPR001320Ionotropic glutamate receptor, C-terminalDomain
A, C
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
A, C
IPR001508Ionotropic glutamate receptor, metazoaFamily
A, C
IPR015683Ionotropic glutamate receptorFamily
B, D
IPR001638Solute-binding protein family 3/N-terminal domain of MltFDomain
B, D
IPR028082Periplasmic binding protein-like IHomologous Superfamily
B, D
IPR001508Ionotropic glutamate receptor, metazoaFamily
B, D
IPR001828Receptor, ligand binding regionDomain
B, D
IPR001320Ionotropic glutamate receptor, C-terminalDomain
B, D
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
B, D
IPR015683Ionotropic glutamate receptorFamily
E [auth I],
F [auth J]		IPR008372Voltage-dependent calcium channel, gamma-8 subunitFamily
E [auth I],
F [auth J]		IPR004031PMP-22/EMP/MP20/ClaudinFamily
E [auth I],
F [auth J]		IPR008368Voltage-dependent calcium channel, gamma subunitFamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALChannels: Other Ion ChannelsGlutamate receptor (AMPA-subtype), GluA1/GluA2/GluA1/GluA2 tetramer in complex with TARP γ8