6QFA
CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25
External Resource: Annotation
- Domain Annotation: ECOD Classification
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Membrane Protein Annotation: OPM
- Membrane Protein Annotation: PDBTM
- Membrane Protein Annotation: MemProtMD
- Membrane Protein Annotation: mpstruc
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | PF02931 | e6qfaB1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: PF02931 | ECOD (1.6) |
A [auth B] | PF02932 | e6qfaB2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: PF02932 | ECOD (1.6) |
H [auth D] | PF02931 | e6qfaD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: PF02931 | ECOD (1.6) |
H [auth D] | PF02932 | e6qfaD2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: PF02932 | ECOD (1.6) |
I [auth E] | PF02931 | e6qfaE1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: PF02931 | ECOD (1.6) |
I [auth E] | PF02932 | e6qfaE2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: PF02932 | ECOD (1.6) |
J [auth A] | PF02931 | e6qfaA1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: PF02931 | ECOD (1.6) |
J [auth A] | PF02932 | e6qfaA2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: PF02932 | ECOD (1.6) |
G [auth C] | PF02931 | e6qfaC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: PF02931 | ECOD (1.6) |
G [auth C] | PF02932 | e6qfaC2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: PF02932 | ECOD (1.6) |
B [auth K] | PF07686 | e6qfaK1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
C [auth O] | PF07686 | e6qfaO1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
D [auth N] | PF07686 | e6qfaN1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
E [auth M] | PF07686 | e6qfaM1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
F [auth L] | PF07686 | e6qfaL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
B [auth K], C [auth O], D [auth N], E [auth M], F [auth L] | Heavy Chain | IGHV1 | - | gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 | SAbDab (2024-05-24) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], G [auth C], H [auth D], I [auth E], J [auth A] | PF02932 | Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb) | Neurotransmitter-gated ion-channel transmembrane region | - | Family |
A [auth B], G [auth C], H [auth D], I [auth E], J [auth A] | PF02931 | Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD) | Neurotransmitter-gated ion-channel ligand binding domain | - | Family |
B [auth K], C [auth O], D [auth N], E [auth M], F [auth L] | PF18304 | SabA N-terminal extracellular adhesion domain (SabA_adhesion) | SabA N-terminal extracellular adhesion domain | This is the N-terminal extracellular adhesion domain of Sialic acid binding adhesin (SabA) present in Helicobacter pylori. The N-terminal domain of SabA functions as a sugar-binding adhesion domain with conserved disulfide bonds. Notably, these amino ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Membrane Protein Annotation: OPM OPM Database Homepage
Chains | External Link | Type | Class | Superfamily | Family |
---|---|---|---|---|---|
OPM | Transmembrane | Alpha-helical polytopic | Pentameric ligand-gated ion channels | Ligand-gated ion channel of neurotransmitter receptors |
Membrane Protein Annotation: PDBTM PDBTM Database Homepage
Chains | External Link | Comment |
---|---|---|
PDBTM | Annotated as membrane protein by PDBTM |
Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage
Chains | External Link | Comment |
---|---|---|
MemProtMD | Annotated as membrane protein by MemProtMD |