6QDJ

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02736	e6qdjA2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
A	PF00063	e6qdjA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myosin-4	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding structural molecule activity structural constituent of muscle cytoskeletal motor activity microfilament motor activity ATP-dependent activity	locomotion cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development myosin filament assembly skeletal myofibril assembly muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly locomotion cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development myosin filament assembly skeletal myofibril assembly muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation anatomical structure development actin filament-based process protein-containing complex assembly cellular component organization or biogenesis skeletal muscle myosin thick filament assembly developmental process actomyosin structure organization actin cytoskeleton organization organelle assembly protein-containing complex organization myosin filament organization anatomical structure morphogenesis striated muscle myosin thick filament assembly myofibril assembly organelle organization anatomical structure formation involved in morphogenesis cellular process striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization behavior egg-laying behavior multicellular organismal process reproductive process multicellular organismal reproductive process reproductive behavior system process muscle contraction muscle system process sarcomere organization	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton myosin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle myosin II complex non-membrane-bounded organelle myofilament myosin filament sarcomere protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton myosin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle myosin II complex non-membrane-bounded organelle myofilament myosin filament sarcomere striated muscle myosin thick filament contractile muscle fiber supramolecular fiber cytoplasm supramolecular polymer supramolecular complex myofibril muscle myosin complex A band

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A	IPR001609	Myosin head, motor domain	Domain
A	IPR002928	Myosin tail	Domain
A	IPR004009	Myosin, N-terminal, SH3-like	Domain
A	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.