Annotations: 6PZW

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6pzwa_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	(Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)) ) [TaxId: 1347105 ],	SCOPe (2.08)
D	d6pzwd_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	(Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)) ) [TaxId: 1347105 ],	SCOPe (2.08)
I [auth C]	d6pzwc_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	(Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)) ) [TaxId: 1347105 ],	SCOPe (2.08)
J [auth B]	d6pzwb_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	(Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)) ) [TaxId: 1347105 ],	SCOPe (2.08)
B [auth I]	d6pzwi1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6pzwe1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d6pzwg1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K [auth L]	d6pzwl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth K]	d6pzwk_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6pzwf_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth J]	d6pzwj_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L [auth H]	d6pzwh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sialidases	8093684	3001607	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Sialidases	8093684	3001607	SCOP2B (2022-06-29)
I [auth C]	SCOP2B Superfamily	Sialidases	8093684	3001607	SCOP2B (2022-06-29)
J [auth B]	SCOP2B Superfamily	Sialidases	8093684	3001607	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00064	e6pzwA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
D	PF00064	e6pzwD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
I [auth C]	PF00064	e6pzwC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
J [auth B]	PF00064	e6pzwB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
C [auth K]	PF07686	e6pzwK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F	PF07686	e6pzwF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
H [auth J]	PF07686	e6pzwJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
L [auth H]	PF07686	e6pzwH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (utative)
D	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (utative)
I [auth C]	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (utative)
J [auth B]	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B [auth I], E, G, K [auth L]	Fab NA-22, anti-N9	L-LAMBDA	Homo sapiens (human)	IGLV2-1401, IGLJ101, IGLC201, IGLC202, IGLC3*04	V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA	IG	FAB-GAMMA-1_LAMBDA	IMGT (202417-0)
C [auth K], F, H [auth J], L [auth H]	Fab NA-22, anti-N9	VH-CH1	Homo sapiens (human)	IGHV3-3018, IGHV3-30-501, IGHJ401, IGHJ402, IGHJ403, IGHG103, IGHG108, IGHG106	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_LAMBDA	IMGT (202417-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth I], E, G, K [auth L]	Light Chain	IGLV2	Lambda	neuraminidase	SAbDab (2024-05-03)
C [auth K], F, H [auth J], L [auth H]	Heavy Chain	IGHV3	-	neuraminidase	SAbDab (2024-05-03)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D, I [auth C], J [auth B]	PF00064	Neuraminidase (Neur)	Neuraminidase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, I [auth C], J [auth B]	Neuraminidase	hydrolase activity, acting on glycosyl bonds exo-alpha-(2->6)-sialidase activity alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity catalytic activity exo-alpha-(2->8)-sialidase activity exo-alpha-(2->3)-sialidase activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process biological process involved in interspecies interaction between organisms non-lytic viral release viral budding viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion assembly exit from host cell viral process viral budding from plasma membrane carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process biological process involved in interspecies interaction between organisms non-lytic viral release viral budding viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion assembly exit from host cell viral process viral budding from plasma membrane viral release from host cell	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane virion component virion membrane
B [auth I], E, G, K [auth L]	NA-22 fragment antigen binding light chain	-	-	-
C [auth K], F, H [auth J], L [auth H]	NA-22 fragment antigen binding heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D, I [auth C], J [auth B]	IPR001860	Glycoside hydrolase, family 34	Family
A, D, I [auth C], J [auth B]	IPR033654	Sialidase, Influenza viruses A/B	Domain
A, D, I [auth C], J [auth B]	IPR036278	Sialidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.