6PXE

Crystal structure of the complex between periplasmic domains of antiholin RI and holin T from T4 phage, in P21

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth T], D [auth B], F [auth D], H [auth F]	PF11031	Bacteriophage T holin (Phage_holin_T)	Bacteriophage T holin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth R], C [auth A], E [auth C], G [auth E]	Antiholin	DNA binding binding organic cyclic compound binding nucleic acid binding molecular function inhibitor activity molecular function regulator activity	biological process involved in interspecies interaction between organisms cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing	host cell plasma membrane host cellular component host cell part host cell membrane cellular anatomical entity host cell periplasmic space
B [auth T], D [auth B], F [auth D], H [auth F]	Holin	pore-forming activity	biological process involved in interspecies interaction between organisms symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism cellular process viral release from host cell biological process involved in interspecies interaction between organisms symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism cellular process viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth R], C [auth A], E [auth C], G [auth E]	IPR034696	Antiholin T4 type	Family
B [auth T], D [auth B], F [auth D], H [auth F]	IPR020982	Bacteriophage T4, GpT, holin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.