6PE2

Drosophila P element transposase strand transfer complex

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, F [auth G]	PF21787	TNP-like, RNase H N-terminal domain (TNP-like_RNaseH_N)	TNP-like, RNase H N-terminal domain	This entry represents the N-terminal segment of the RNase H domain from Drosophila Transposable element P transposase (TNP) and its homologue from human, THAP9. The catalytic RNase H domain in these proteins is interrupted by the GTP-binding insertio ...	This entry represents the N-terminal segment of the RNase H domain from Drosophila Transposable element P transposase (TNP) and its homologue from human, THAP9. The catalytic RNase H domain in these proteins is interrupted by the GTP-binding insertion domain (GBD) [1].	Domain
A, F [auth G]	PF21789	TNP-like, RNase H C-terminal domain (TNP-like_RNaseH_C)	TNP-like, RNase H C-terminal domain	This domain represents the C-terminal segment of the RNase H domain from Drosophila melanogaster transposable element P transposase (TNP) and its homologue from human THAP9. The catalytic RNase H domain of these proteins is interrupted by the GTP-bin ...	This domain represents the C-terminal segment of the RNase H domain from Drosophila melanogaster transposable element P transposase (TNP) and its homologue from human THAP9. The catalytic RNase H domain of these proteins is interrupted by the GTP-binding insertion domain (GBD, Pfam:PF21788) [1]. The N-terminal segment of the RNase H domain is represented in Pfam:PF21787.	Domain
A, F [auth G]	PF21788	TNP-like, GTP-binding insertion domain (TNP-like_GBD)	TNP-like, GTP-binding insertion domain	This entry represents a GTP-binding insertion domain (GBD) from Transposable element P transposase from Drosophila and its human homologue, THAP9 [1]. This domain is inserted in the RNaseH domain and adopts a mostly alpha-helical fold, similar to tha ...	This entry represents a GTP-binding insertion domain (GBD) from Transposable element P transposase from Drosophila and its human homologue, THAP9 [1]. This domain is inserted in the RNaseH domain and adopts a mostly alpha-helical fold, similar to that in Hermes, Tn5 or RAG1 proteins. This domain is involved in protein-DNA interactions [1].	Domain
B, G [auth H]	PF12596	87kDa Transposase (Tnp_P_element_C)	87kDa Transposase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, F [auth G]	Transposable element P transposase	DNA binding sequence-specific DNA binding P-element binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding transferase activity catalytic activity DNA binding sequence-specific DNA binding P-element binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding transferase activity catalytic activity transposase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid	DNA recombination primary metabolic process DNA metabolic process transposition DNA transposition nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular process metabolic process macromolecule metabolic process DNA integration	-
B, G [auth H]	Transposable element P transposase	DNA binding sequence-specific DNA binding P-element binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding transferase activity catalytic activity DNA binding sequence-specific DNA binding P-element binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding transferase activity catalytic activity transposase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid	DNA recombination primary metabolic process DNA metabolic process transposition DNA transposition nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular process metabolic process macromolecule metabolic process DNA integration	-
C, H [auth I]	DNA (5'-D(PCPGPAPAPCPTPAPTP*A)-3')	-	-	-
D, I [auth J]	DNA (27-MER)	-	-	-
E, J [auth K]	DNA (56-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, F [auth G]	IPR006612	THAP-type zinc finger	Domain
A, F [auth G]	IPR022242	Transposable element P transposase-like, C-terminal	Domain
A, F [auth G]	IPR048366	Transposable element P transposase-like, GTP-binding insertion domain	Domain
A, F [auth G]	IPR048367	Transposable element P transposase-like, RNase H, C-terminal domain	Domain
A, F [auth G]	IPR038441	THAP-type zinc finger superfamily	Homologous Superfamily
A, F [auth G]	IPR048365	Transposable element P transposase-like, RNase H domain, N-terminal	Domain
B, G [auth H]	IPR006612	THAP-type zinc finger	Domain
B, G [auth H]	IPR022242	Transposable element P transposase-like, C-terminal	Domain
B, G [auth H]	IPR048366	Transposable element P transposase-like, GTP-binding insertion domain	Domain
B, G [auth H]	IPR048367	Transposable element P transposase-like, RNase H, C-terminal domain	Domain
B, G [auth H]	IPR038441	THAP-type zinc finger superfamily	Homologous Superfamily
B, G [auth H]	IPR048365	Transposable element P transposase-like, RNase H domain, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.