Annotations: 6PAT

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07701	Heme NO binding associated (HNOBA)	Heme NO binding associated	The HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals ...	The HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.	Domain
A	PF00211	Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)	Adenylate and Guanylate cyclase catalytic domain	-	Domain
B	PF07700	Haem-NO-binding (HNOB)	Haem-NO-binding	The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO [3]. It is predicted to function ...	The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO [3]. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.	Domain
B	PF00211	Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)	Adenylate and Guanylate cyclase catalytic domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Soluble guanylyl cyclase alpha-1 subunit	binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction intracellular signal transduction cell communication	intracellular anatomical structure cytoplasm cellular anatomical entity
B	Soluble guanylyl cyclase beta-1 subunit	binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction intracellular signal transduction cell communication	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Conserved Site
A	IPR038158	H-NOX domain superfamily	Homologous Superfamily
A	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily	Homologous Superfamily
A	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain
A	IPR011644	Heme NO-binding	Domain
A	IPR011645	Haem NO binding associated	Domain
A	IPR042463	Haem NO binding associated domain superfamily	Homologous Superfamily
A	IPR029787	Nucleotide cyclase	Homologous Superfamily
B	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Conserved Site
B	IPR038158	H-NOX domain superfamily	Homologous Superfamily
B	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily	Homologous Superfamily
B	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain
B	IPR011644	Heme NO-binding	Domain
B	IPR011645	Haem NO binding associated	Domain
B	IPR042463	Haem NO binding associated domain superfamily	Homologous Superfamily
B	IPR029787	Nucleotide cyclase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.