6PAT

Active State of Manduca sexta soluble Guanylate Cyclase


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07700Haem-NO-binding (HNOB)Haem-NO-bindingThe HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO [3]. It is predicted to function ...The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO [3]. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.
Domain
PF00211Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)Adenylate and Guanylate cyclase catalytic domain- Domain
PF07701Heme NO binding associated (HNOBA)Heme NO binding associatedThe HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals ...The HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.
Domain
PF00211Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)Adenylate and Guanylate cyclase catalytic domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Soluble guanylyl cyclase beta-1 subunit
Soluble guanylyl cyclase alpha-1 subunit