Crystal structure of the broadly neutralizing antibody N49P6 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core.
External Resource: Annotation
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
A [auth G] | SCOP2B Superfamily | gp120 core | 8096276 | 3001390 | SCOP2B (2022-06-29) |
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
A [auth G] | PF00516 | e6oz2G1 | A: a+b two layers | X: Ribosomal protein L31e-like | H: Ribosomal protein L31e/gp120 outer domain (From Topology) | T: Ribosomal protein L31e/gp120 outer domain | F: PF00516 | ECOD (1.6) |
A [auth G] | PF00516 | e6oz2G2 | A: a+b two layers | X: gp120 inner domain (From Topology) | H: gp120 inner domain (From Topology) | T: gp120 inner domain | F: PF00516 | ECOD (1.6) |
C [auth L] | PF07654 | e6oz2L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
C [auth L] | PF07686 | e6oz2L2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
B [auth H] | PF07654 | e6oz2H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
B [auth H] | PF07686 | e6oz2H2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
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C [auth L] | Fab N49P6, anti-HIV-1, broadly neutralizing | L-LAMBDA | Homo sapiens (human) | IGLV2-11*01, IGLV2-11*02, IGLJ2*01, IGLJ3*02, IGLJ3*01, IGLC2*01, IGLC2*02, IGLC3*04 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-1_KAPPA | IMGT (202416-0) |
B [auth H] | Fab N49P6, anti-HIV-1, broadly neutralizing | VH-CH1 | Homo sapiens (human) | IGHV1-2*02, IGHV1-2*07, IGHJ2*01, IGHG1*03, IGHG1*08, IGHG1*06 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202416-0) |
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
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C [auth L] | Light Chain | IGLV2 | Lambda | clade a/e 93th057 hiv-1 gp120 core | SAbDab (2024-04-26) |
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
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A [auth G] | clade A/E 93TH057 HIV-1 gp120 core | - | - | |
C [auth L] | N49P6 antibody Fab light chain | - | - | - |
B [auth H] | N49P6 antibody Fab heavy chain | - | - | - |