6OBD

Crystal structure of anti-GLD52 Fab complex with human GLD52 peptide mimetic

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Thera-SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07654	e6obdA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A	PF07686	e6obdA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C [auth L]	PF07654	e6obdL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth L]	PF07686	e6obdL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B	PF07654	e6obdB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B	PF07686	e6obdB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth H]	PF07654	e6obdH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D [auth H]	PF07686	e6obdH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
D [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, C [auth L]	Antibody Fab Fragment, anti-GLD52	L-KAPPA	Homo sapiens (human)	IGKV2D-2902, IGKJ202, IGKC*01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)
B, D [auth H]	Antibody Fab Fragment, anti-GLD52	VH-CH1	Homo sapiens (human)	IGHV3-7201, IGHJ401, IGHJ402, IGHJ403, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG1*11	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, C [auth L]	Light Chain	IGKV1	Kappa	gld52 peptide mimetic	SAbDab (2024-04-26)
B, D [auth H]	Heavy Chain	IGHV3	-	gld52 peptide mimetic	SAbDab (2024-04-26)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
A, C [auth L]	Gatralimab	CD52	Therapeutic SAbDab (2024-04-26)
B, D [auth H]	Gatralimab	CD52	Therapeutic SAbDab (2024-04-26)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E, F	PF15116	CAMPATH-1 antigen (CD52)	CAMPATH-1 antigen	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth L]	anti-GLD52 Fab light chain	-	-	-
B, D [auth H]	anti-GLD52 Fab heavy chain	-	-	-
E, F	GLD52 peptide mimetic	-	respiratory burst metabolic process positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality	membrane cellular anatomical entity side of membrane cell periphery plasma membrane membrane-bounded organelle cell projection sperm midpiece organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection membrane cellular anatomical entity side of membrane cell periphery plasma membrane membrane-bounded organelle cell projection sperm midpiece organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E, F	IPR026643	CAMPATH-1 antigen (CD52)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E, F	Pharos: P31358	nephrosclerosis ovarian cancer Recurrent chronic lymphocytic leukemia tuberculosis atypical teratoid rhabdoid tumor chronic kidney disease cutaneous lupus erythematosus interstitial cystitis lung cancer lymphoplasmacytic lymphoma malignant pancreatic neoplasm non-small cell lung carcinoma pituitary cancer relapsing-remitting multiple sclerosis ulcerative colitis nephrosclerosis ovarian cancer Recurrent chronic lymphocytic leukemia tuberculosis atypical teratoid rhabdoid tumor chronic kidney disease cutaneous lupus erythematosus interstitial cystitis lung cancer lymphoplasmacytic lymphoma malignant pancreatic neoplasm non-small cell lung carcinoma pituitary cancer relapsing-remitting multiple sclerosis ulcerative colitis B-cell chronic lymphocytic leukemia chronic obstructive pulmonary disease ductal breast carcinoma in situ invasive ductal breast carcinoma lung carcinoma malignant colon neoplasm nasopharyngeal carcinoma osteosarcoma psoriasis Sjogren syndrome breast carcinoma head and neck cancer lung adenocarcinoma lymphoma malignant glioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.