6O9B

Crystal structure of HLA-A3*01 in complex with a wild-type beta-catenin peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054579	3000071	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8033653	3000521	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8003766	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set_2	e6o9bA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
A	MHC_I	e6o9bA2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
B	C1-set_2	e6o9bB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (utative)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	MH1 HLA-A*0362	I-ALPHA	Homo sapiens (human)	HLA-A0306, HLA-A0307, HLA-A0310, HLA-A0319, HLA-A0316, HLA-A0313, HLA-A0320, HLA-A0322, HLA-A0315, HLA-A0327, HLA-A0338, HLA-A0331, HLA-A0328, HLA-A0335, HLA-A0344, HLA-A7413, HLA-A0340, HLA-A0343, HLA-A0346, HLA-A0342, HLA-A0345, HLA-A0351, HLA-A0350, HLA-A0356, HLA-A0352, HLA-A0361, HLA-A0360, HLA-A0353, HLA-A0362, HLA-A0354, HLA-A0349, HLA-A0364, HLA-A0365, HLA-A0373, HLA-A0374, HLA-A0375, HLA-A*0366	G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2, C-LIKE-DOMAIN C-LIKE	MH	MH1-ALPHA_B2M	IMGT (202415-0)
B	MH1 HLA-A*0362	B2M	Homo sapiens (human)	B2M01, B2M02	C-LIKE-DOMAIN C-LIKE	MH	MH1-ALPHA_B2M	IMGT (202415-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
A	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
B	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HLA class I histocompatibility antigen, A-3 alpha chain	binding antigen binding peptide antigen binding peptide binding TAP complex binding protein-containing complex binding beta-2-microglobulin binding protein binding signaling receptor binding T cell receptor binding CD8 receptor binding RNA binding organic cyclic compound binding nucleic acid binding binding antigen binding peptide antigen binding peptide binding TAP complex binding protein-containing complex binding beta-2-microglobulin binding protein binding signaling receptor binding T cell receptor binding CD8 receptor binding RNA binding organic cyclic compound binding nucleic acid binding TAP binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated cytotoxicity T cell mediated immunity response to tumor cell T cell mediated cytotoxicity directed against tumor cell target response to stimulus immune response immune response to tumor cell leukocyte mediated cytotoxicity adaptive immune response response to biotic stimulus immune effector process T cell mediated immune response to tumor cell immune system process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated cytotoxicity T cell mediated immunity response to tumor cell T cell mediated cytotoxicity directed against tumor cell target response to stimulus immune response immune response to tumor cell leukocyte mediated cytotoxicity adaptive immune response response to biotic stimulus immune effector process T cell mediated immune response to tumor cell immune system process leukocyte mediated immunity cellular process cell killing multicellular organismal process regulation of cellular process positive regulation of cell population proliferation CD8-positive, alpha-beta T cell activation regulation of alpha-beta T cell activation regulation of leukocyte activation CD8-positive, alpha-beta T cell proliferation positive regulation of alpha-beta T cell proliferation regulation of cell activation positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of cell activation T cell activation alpha-beta T cell proliferation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of CD8-positive, alpha-beta T cell proliferation alpha-beta T cell activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation regulation of biological process positive regulation of T cell activation cell population proliferation regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of alpha-beta T cell activation mononuclear cell proliferation regulation of cell population proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of biological process positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte proliferation leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of cellular process T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation regulation of lymphocyte activation regulation of immune effector process positive regulation of leukocyte mediated immunity T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production regulation of T cell mediated immunity regulation of cytokine production involved in immune response regulation of adaptive immune response cellular metabolic process regulation of cellular metabolic process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus positive regulation of production of molecular mediator of immune response regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of response to stimulus regulation of T cell cytokine production organic substance metabolic process regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process cytokine production involved in immune response production of molecular mediator of immune response regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus innate immune response detection of external biotic stimulus detection of biotic stimulus detection of bacterium detection of stimulus detection of other organism antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I negative regulation of biological process negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity natural killer cell mediated immunity regulation of natural killer cell mediated immunity regulation of innate immune response negative regulation of immune response negative regulation of immune effector process negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity regulation of response to external stimulus negative regulation of response to biotic stimulus protection from natural killer cell mediated cytotoxicity regulation of response to stress negative regulation of leukocyte mediated cytotoxicity negative regulation of cellular process negative regulation of cell killing negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity negative regulation of immune system process negative regulation of leukocyte mediated immunity negative regulation of innate immune response positive regulation of memory T cell activation regulation of memory T cell activation memory T cell activation peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly MHC protein complex assembly cellular component organization or biogenesis antigen processing and presentation of exogenous peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen positive regulation of leukocyte mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of T cell mediated cytotoxicity positive regulation of cell killing cellular response to stimulus immune response-regulating cell surface receptor signaling pathway signaling cell communication immune response-activating signaling pathway immune response-regulating signaling pathway signal transduction cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway T cell receptor signaling pathway antigen receptor-mediated signaling pathway activation of immune response antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation via MHC class Ib regulation of type II interferon production type II interferon production positive regulation of type II interferon production defense response to Gram-positive bacterium	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex intracellular organelle intracellular anatomical structure endoplasmic reticulum exit site endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane organelle membrane endocytic vesicle Golgi apparatus Golgi membrane MHC class I peptide loading complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane Golgi apparatus subcompartment Golgi cisterna Golgi stack Golgi medial cisterna lumenal side of endoplasmic reticulum membrane lumenal side of membrane endosome membrane endosome recycling endosome recycling endosome membrane early endosome early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
B	Beta-2-microglobulin	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding identical protein binding protein binding protein homodimerization activity protein dimerization activity structural molecule activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response regulation of cellular metabolic process immune effector process regulation of gene expression regulation of leukocyte mediated immunity regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of cellular metabolic process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process adaptive immune response regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to iron ion cellular response to chemical stimulus response to metal ion response to chemical response to iron ion cellular response to iron(III) ion response to iron(III) ion multicellular organismal-level iron ion homeostasis multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis regulation of neuron projection development regulation of cellular component organization cellular developmental process cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization system development developmental process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization positive regulation of protein binding regulation of binding positive regulation of binding regulation of protein binding positive regulation of molecular function regulation of molecular function regulation of receptor binding regulation of transferrin receptor binding positive regulation of receptor binding positive regulation of transferrin receptor binding regulation of developmental process regulation of cell differentiation regulation of cell development myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation regulation of localization import into cell positive regulation of cellular component organization transport vesicle-mediated transport localization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of transport endocytosis receptor-mediated endocytosis peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component biogenesis cellular component assembly protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly regulation of neurogenesis regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development negative regulation of multicellular organismal process positive regulation of ferrous iron binding regulation of ferrous iron binding negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of leukocyte mediated cytotoxicity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity regulation of T cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing cell killing iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport metal ion transport system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell amyloid fibril formation supramolecular fiber organization protein homotetramerization protein complex oligomerization protein tetramerization protein homooligomerization antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II negative regulation of receptor binding negative regulation of protein binding negative regulation of binding negative regulation of molecular function peptide antigen assembly with MHC class II protein complex MHC class II protein complex assembly cellular response to nicotine response to nicotine regulation of cellular senescence cellular senescence positive regulation of cellular senescence cellular response to stress response to stress antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I behavior learning or memory cognition regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion positive regulation of leukocyte activation regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of leukocyte cell-cell adhesion regulation of lymphocyte activation negative regulation of forebrain neuron differentiation forebrain development regulation of forebrain neuron differentiation central nervous system neuron differentiation head development forebrain generation of neurons animal organ development brain development central nervous system development forebrain neuron differentiation negative regulation of neuron differentiation regulation of neuron differentiation regulation of monoatomic ion transport regulation of iron ion transport regulation of metal ion transport response to organic substance biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to molecule of bacterial origin response to biotic stimulus	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex intracellular anatomical structure cytoplasm cytosol MHC class I protein complex MHC protein complex endosome membrane endosome intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome organelle membrane phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum Golgi membrane MHC class I peptide loading complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen secretory granule secretory vesicle specific granule anchoring junction cell junction focal adhesion cell-substrate junction MHC class II protein complex early endosome endosome lumen early endosome lumen recycling endosome recycling endosome membrane tertiary granule lumen tertiary granule early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
C	Catenin beta-1	protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding histone methyltransferase binding transcription coregulator binding transcription corepressor binding nuclear estrogen receptor binding I-SMAD binding protein-containing complex binding chromatin binding transmembrane transporter binding disordered domain specific binding protein domain specific binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development oviduct development reproductive system development reproductive process developmental process involved in reproduction reproductive structure development dorsal/ventral pattern formation dorsal/ventral axis specification pattern specification process axis specification regionalization regulation of cellular process cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development neurogenesis cell differentiation cellular process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cell population proliferation regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation smooth muscle cell proliferation embryonic skeletal joint development limb development chordate embryonic development embryonic limb morphogenesis embryonic appendage morphogenesis embryo development embryonic skeletal joint morphogenesis embryo development ending in birth or egg hatching skeletal system development animal organ morphogenesis embryonic organ development embryonic skeletal system morphogenesis embryonic organ morphogenesis embryonic skeletal limb joint morphogenesis appendage development embryonic morphogenesis animal organ development appendage morphogenesis limb joint morphogenesis embryonic skeletal system development skeletal system morphogenesis limb morphogenesis heart morphogenesis cardioblast proliferation regulation of cardioblast proliferation animal organ formation regulation of secondary heart field cardioblast proliferation heart development heart formation cell proliferation involved in heart morphogenesis regulation of cell proliferation involved in heart morphogenesis response to fibroblast growth factor positive regulation of cell communication cellular response to growth factor stimulus positive regulation of signal transduction positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling response to endogenous stimulus regulation of cellular response to growth factor stimulus regulation of response to stimulus fibroblast growth factor receptor signaling pathway regulation of cell communication response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway positive regulation of signaling regulation of timing of anagen epidermis development molting cycle process anagen hair cycle phase skin epidermis development hair follicle development hair follicle maturation regulation of hair follicle maturation epithelium development biological phase hair cycle developmental maturation tissue development skin development anatomical structure maturation molting cycle hair cycle process maintenance of cell number stem cell population maintenance prostate gland development gland development epithelial cell proliferation involved in prostate gland development urogenital system development epithelial cell proliferation trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission detection of external stimulus detection of stimulus detection of mechanical stimulus detection of muscle stretch response to mechanical stimulus response to external stimulus response to abiotic stimulus detection of abiotic stimulus response to muscle stretch adherens junction organization adherens junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis cell-cell junction organization cell-cell junction assembly negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of gliogenesis negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process regulation of glial cell differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of oligodendrocyte differentiation negative regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation negative regulation of multicellular organismal process regulation of oligodendrocyte differentiation positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of sulfur metabolic process sulfur compound metabolic process positive regulation of macromolecule metabolic process positive regulation of heparan sulfate proteoglycan biosynthetic process regulation of protein metabolic process regulation of heparan sulfate proteoglycan biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process sulfur compound biosynthetic process proteoglycan metabolic process positive regulation of proteoglycan biosynthetic process proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of sulfur metabolic process positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of biosynthetic process protein metabolic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process positive regulation of cellular biosynthetic process epidermal cell differentiation epithelial cell differentiation hair cell differentiation generation of neurons neuron differentiation negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization sexual reproduction multicellular organismal reproductive process oogenesis cellular process involved in reproduction in multicellular organism female gamete generation gamete generation oocyte development germ cell development oocyte differentiation developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell growth cell morphogenesis cell projection morphogenesis neuron projection morphogenesis neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth developmental growth involved in morphogenesis neuron development branching morphogenesis of an epithelial tube respiratory tube development lung morphogenesis lung development respiratory system development epithelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium sympathetic nervous system development ganglion development autonomic nervous system development sympathetic ganglion development positive regulation of mesenchymal cell proliferation positive regulation of cell population proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation synapse organization vesicle localization transport synaptic vesicle clustering synaptic vesicle cycle establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse organelle localization establishment of localization in cell synaptic vesicle localization cell maturation anterior/posterior axis specification anterior/posterior pattern specification positive regulation of odontoblast differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation neuroepithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation apoptotic signaling pathway myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis lens morphogenesis in camera-type eye sensory organ morphogenesis camera-type eye development sensory system development lens development in camera-type eye negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development negative regulation of post-translational protein modification regulation of protein sumoylation regulation of protein modification process peptidyl-lysine modification peptidyl-amino acid modification negative regulation of protein modification process protein modification process regulation of protein modification by small protein conjugation or removal negative regulation of protein sumoylation negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein sumoylation macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal outflow tract morphogenesis cell fate specification cell fate commitment forebrain development glial cell migration telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration head development brain development cerebral cortex radially oriented cell migration pallium development cerebral cortex radial glia-guided migration telencephalon development hindbrain development positive regulation of gene expression regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation in utero embryonic development intracellular signal transduction intracellular signaling cassette MAPK cascade cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process T cell differentiation neuron fate commitment cell fate determination neuron fate determination positive regulation of determination of dorsal identity regulation of determination of dorsal identity determination of bilateral symmetry determination of dorsal/ventral asymmetry positive regulation of multicellular organismal process determination of dorsal identity specification of symmetry intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process negative regulation of signaling negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of response to stimulus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signal transduction neuron intrinsic apoptotic signaling pathway in response to oxidative stress negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation stem cell differentiation mesenchymal stem cell differentiation mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis microtubule organizing center organization regulation of cell cycle process microtubule cytoskeleton organization centriole-centriole cohesion organelle organization centrosome cycle microtubule-based process cell cycle regulation of cell cycle regulation of centriole-centriole cohesion cytoskeleton organization cell cycle process multicellular organismal-level homeostasis homeostatic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption ossification osteoblast differentiation immune system development hematopoietic or lymphoid organ development thymus development transcription by RNA polymerase II cranial ganglion development nerve development cranial nerve development foregut regionalization developmental induction regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis specification of animal organ identity regulation of branching involved in lung morphogenesis regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud morphogenesis of an epithelial fold morphogenesis of embryonic epithelium regulation of embryonic development lung field specification lung induction primary lung bud formation positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction glial cell fate determination glial cell fate commitment pancreas development positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade embryonic axis specification embryonic pattern specification positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process dopaminergic neuron differentiation midbrain development midbrain dopaminergic neuron differentiation neuron migration regulation of transcription by RNA polymerase II regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II positive regulation of transcription by RNA polymerase II transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation DNA-templated transcription elongation response to chemical response to xenobiotic stimulus epithelial cell differentiation involved in prostate gland development digestive system development foregut morphogenesis digestive tract development embryonic foregut morphogenesis digestive tract morphogenesis myoblast proliferation astrocyte-dopaminergic neuron signaling glial cell-neuron signaling regulation of epithelial cell differentiation involved in kidney development regulation of nephron tubule epithelial cell differentiation epithelial cell differentiation involved in kidney development nephron tubule epithelial cell differentiation cell differentiation involved in kidney development establishment of organelle localization establishment of vesicle localization synaptic vesicle transport dorsal root ganglion development genitalia development sex differentiation male sex differentiation male genitalia development endothelium development morphogenesis of an endothelium endothelial tube morphogenesis epidermis morphogenesis hair follicle morphogenesis embryonic hindlimb morphogenesis hindlimb morphogenesis mesenchymal cell proliferation involved in lung development branching involved in blood vessel morphogenesis positive regulation of myoblast proliferation regulation of myoblast proliferation metanephros development metanephros morphogenesis positive regulation of organelle organization telomere organization regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of telomere maintenance via telomere lengthening positive regulation of telomere maintenance DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of telomere maintenance via telomerase positive regulation of endothelial cell differentiation endothelial cell differentiation regulation of endothelial cell differentiation regulation of synapse structure or activity regulation of synapse assembly regulation of biological quality regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly connective tissue development chondrocyte differentiation cartilage development negative regulation of transcription by RNA polymerase II formation of primary germ layer gastrulation cell fate commitment involved in formation of primary germ layer endoderm development endoderm formation endodermal cell fate commitment endodermal cell differentiation gastrulation with mouth forming second regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development epithelial to mesenchymal transition mesenchymal cell differentiation regulation of localization regulation of protein localization regulation of cellular localization regulation of protein localization to cell surface renal vesicle morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation involved in kidney development metanephric renal vesicle morphogenesis renal vesicle development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron development mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation mesenchymal to epithelial transition metanephric nephron morphogenesis cell differentiation involved in metanephros development hypothalamus development diencephalon development limbic system development regulation of reproductive process regulation of epithelial cell proliferation involved in prostate gland development positive regulation of reproductive process positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in prostate gland development regulation of epithelial cell proliferation regulation of mitotic cell cycle, embryonic negative regulation of cell cycle mitotic cell cycle negative regulation of mitotic cell cycle mitotic cell cycle, embryonic regulation of mitotic cell cycle negative regulation of mitotic cell cycle, embryonic organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process fibroblast proliferation regulation of fibroblast proliferation establishment of blood-retinal barrier acinar cell differentiation glandular epithelial cell differentiation muscle structure development smooth muscle cell differentiation muscle cell differentiation regulation of protein ubiquitination protein ubiquitination regulation of cartilage development regulation of chondrocyte differentiation negative regulation of cartilage development negative regulation of chondrocyte differentiation negative regulation of gene expression proximal/distal pattern formation response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound embryonic digit morphogenesis ectoderm development regulation of muscle tissue development skeletal muscle tissue development positive regulation of skeletal muscle tissue development regulation of skeletal muscle tissue development skeletal muscle organ development positive regulation of muscle tissue development muscle tissue development muscle organ development neuroblast proliferation neural precursor cell proliferation embryonic forelimb morphogenesis forelimb morphogenesis regulation of calcium ion import regulation of calcium ion transport regulation of transport regulation of monoatomic ion transport calcium ion transport metal ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport regulation of leukocyte activation regulation of cell activation leukocyte proliferation lymphocyte proliferation regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of T cell activation regulation of T cell proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of leukocyte differentiation regulation of osteoclast differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of immune system process regulation of hemopoiesis embryonic brain development protein polyubiquitination central nervous system vasculogenesis vasculogenesis genitalia morphogenesis sister chromatid cohesion centromeric sister chromatid cohesion regulation of centromeric sister chromatid cohesion regulation of sister chromatid cohesion cell adhesion lung epithelium development lung epithelial cell differentiation lung cell differentiation positive regulation of morphogenesis of an epithelium positive regulation of branching involved in lung morphogenesis neural plate development cell-matrix adhesion cell-substrate adhesion ectodermal placode morphogenesis hair follicle placode formation ectodermal placode formation ectodermal placode development regulation of myelination myelination axon ensheathment ensheathment of neurons establishment of blood-brain barrier lung-associated mesenchyme development odontogenesis of dentin-containing tooth odontogenesis cranial skeletal system development embryonic epithelial tube formation tube formation epithelial tube formation nephron tubule formation renal vesicle formation embryonic heart tube development trachea morphogenesis trachea formation trachea development negative regulation of cell population proliferation regulation of osteoblast differentiation positive regulation of osteoblast differentiation renal inner medulla development cellular response to nitrogen compound response to alcohol response to organonitrogen compound cellular response to organic cyclic compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to organonitrogen compound response to indole-3-methanol cellular response to indole-3-methanol cellular response to organic substance cell-cell adhesion renal outer medulla development positive regulation of nervous system development regulation of neuroblast proliferation positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation tongue development fungiform papilla formation fungiform papilla development fungiform papilla morphogenesis tongue morphogenesis	membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola cellular anatomical entity membrane microdomain cell periphery flotillin complex plasma membrane region cell-cell junction membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola cellular anatomical entity membrane microdomain cell periphery flotillin complex plasma membrane region cell-cell junction intercalated disc anchoring junction cell junction fascia adherens cell-cell contact zone focal adhesion cell-substrate junction membrane-bounded organelle RNA polymerase II transcription regulator complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle beta-catenin-TCF7L2 complex intracellular organelle catenin-TCF7L2 complex organelle beta-catenin-TCF complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex Schaffer collateral - CA1 synapse synapse protein-DNA complex euchromatin chromatin chromosome intracellular non-membrane-bounded organelle non-membrane-bounded organelle cell projection cell leading edge plasma membrane bounded cell projection lamellipodium postsynapse postsynaptic membrane synaptic membrane cytoskeleton spindle spindle pole microtubule cytoskeleton Z disc sarcomere I band contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex apical part of cell extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle actin-based cell projection microvillus microvillus membrane cell projection membrane presynapse presynaptic membrane cell cortex cytoplasmic region presynaptic active zone cytoplasmic component cell cortex region presynaptic active zone extrinsic component of plasma membrane catenin complex extrinsic component of membrane Scrib-APC-beta-catenin complex glutamatergic synapse RNA polymerase II transcription repressor complex beta-catenin-ICAT complex transcription repressor complex adherens junction centrosome microtubule organizing center membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytosol lateral plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane perinuclear region of cytoplasm postsynaptic density, intracellular component postsynaptic specialization postsynaptic specialization, intracellular component postsynaptic density neuron to neuron synapse asymmetric synapse apicolateral plasma membrane Wnt signalosome apical junction complex bicellular tight junction tight junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR010579	MHC class I, alpha chain, C-terminal	Domain
A	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR003597	Immunoglobulin C1-set	Domain
A	IPR011161	MHC class I-like antigen recognition-like	Domain
A	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR003597	Immunoglobulin C1-set	Domain
B	IPR015707	Beta-2-Microglobulin	Family
C	IPR016024	Armadillo-type fold	Homologous Superfamily
C	IPR000225	Armadillo	Repeat
C	IPR011989	Armadillo-like helical	Homologous Superfamily
C	IPR013284	Beta-catenin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P04439	malignant glioma parapsoriasis plasma cell myeloma Stevens-Johnson syndrome thrombocytopenia ankylosing spondylitis mixed glioma juvenile idiopathic arthritis birdshot chorioretinopathy pancreatic ductal adenocarcinoma Drug-Induced Acute Liver Injury pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia paranoid schizophrenia pilocytic astrocytoma glioma malignant glioma parapsoriasis plasma cell myeloma Stevens-Johnson syndrome thrombocytopenia ankylosing spondylitis mixed glioma juvenile idiopathic arthritis birdshot chorioretinopathy pancreatic ductal adenocarcinoma Drug-Induced Acute Liver Injury pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia paranoid schizophrenia pilocytic astrocytoma glioma prostate carcinoma allergic rhinitis schizophrenia herpes zoster autism juvenile dermatomyositis toxic epidermal necrolysis autoimmune disease lung adenocarcinoma malignant ependymoma breast cancer nasopharyngeal disease cutaneous lupus erythematosus pancreatic intraductal papillary-mucinous carcinoma Duchenne muscular dystrophy Graves disease psoriatic arthritis alopecia squamous cell lung carcinoma astrocytic tumor IgA glomerulonephritis subependymal giant cell astrocytoma autism spectrum disorder bipolar disorder lung cancer cancer ovarian cancer dermatomyositis pancreatic intraductal papillary-mucinous neoplasm drug-induced liver injury endogenous depression glioblastoma plasma cell neoplasm head and neck squamous cell carcinoma rheumatoid arthritis alopecia areata hepatocellular carcinoma attention deficit hyperactivity disorder, inattentive type inherited disease susceptibility liver disease vitiligo lung carcinoma cervical cancer myeloid neoplasm colorectal cancer
B	Pharos: P61769	familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma ovarian cancer acquired metabolic disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma psoriasis Sjogren syndrome glioblastoma juvenile dermatomyositis lung adenocarcinoma lymphatic system disease pancreatic intraductal papillary-mucinous carcinoma acute kidney failure periodic fever syndrome bone marrow disease rheumatoid arthritis Down syndrome subependymal giant cell astrocytoma lung cancer lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm cancer schizophrenia ulcerative colitis
C	Pharos: P35222	medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma craniopharyngioma adrenal cortex carcinoma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma craniopharyngioma adrenal cortex carcinoma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor breast cancer cirrhosis of liver malignant mesothelioma melanotic medulloblastoma breast carcinoma prostate cancer liver cancer cecal neoplasm Neoplasm Metastasis cervical cancer adenocarcinoma tubular adenocarcinoma malignant pancreatic neoplasm papillary adenoma adult medulloblastoma mantle cell lymphoma intellectual disability medullomyoblastoma with myogenic differentiation microcystic adenoma cecum cancer childhood medulloblastoma exudative vitreoretinopathy 7 follicular thyroid adenoma papillary craniopharyngioma intestinal cancer cancer adamantinous craniopharyngioma malignant colon neoplasm granular cell carcinoma adrenal gland cancer hepatocellular carcinoma desmoplastic/nodular medulloblastoma parathyroid gland adenoma hereditary Wilms tumor atypical teratoid rhabdoid tumor medulloblastoma with extensive nodularity intestinal disease brain disease drug-induced liver injury plasma cell myeloma kidney disease endometrial carcinoma psoriasis liver neoplasm exudative vitreoretinopathy 1 lung benign neoplasm colon carcinoma non-small cell lung carcinoma stomach disease lymphatic system disease gastric carcinoma malignant ependymoma ovarian neoplasm hematologic disease adrenal cortex adenoma uterine disease cribriform carcinoma pancreatic intraductal papillary-mucinous neoplasm cystadenoma peritoneal neoplasm benign colon neoplasm Perlman syndrome intestinal neoplasm breast disease endometriosis prostate disease esophageal squamous cell carcinoma lung disease colonic neoplasm osteoporosis toxic epidermal necrolysis colorectal carcinoma ovarian carcinoma glioblastoma urinary bladder disease pancreatic ductal adenocarcinoma cribriform carcinoma of breast pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia melanoma Emery-Dreifuss muscular dystrophy primitive neuroectodermal tumor large cell medulloblastoma endometrium carcinoma in situ liver disease schizophrenia lung adenocarcinoma colorectal adenocarcinoma osteosarcoma gastric adenocarcinoma tuberculosis ovarian disease adrenal carcinoma pancreatic intraductal papillary-mucinous carcinoma vertebral column disease cutaneous melanoma pancreatic neoplasm adult hepatocellular carcinoma