6O7X

Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 3

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth O]SCOP2B SuperfamilyVacuolar ATP synthase subunit C8042806 3001744 SCOP2B (2022-06-29)
N [auth P]SCOP2B SuperfamilyARM repeat-like8033221 3000116 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth O]PF03223e6o7xO1 A: alpha bundlesX: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)H: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)T: helical bundle domain in vacuolar ATP synthase subunit CF: PF03223ECOD (1.6)
A [auth O]PF03223e6o7xO3 A: a+b two layersX: Alpha-beta plaitsH: ferredoxin-like domain in vacuolar ATP synthase subunit C (From Topology)T: ferredoxin-like domain in vacuolar ATP synthase subunit CF: PF03223ECOD (1.6)
T [auth d]PF01992e6o7xd1 A: alpha bundlesX: V-type ATP synthase subunit CH: V-type ATP synthase subunit C (From Topology)T: V-type ATP synthase subunit CF: PF01992ECOD (1.6)
AA [auth m]PF00137e6o7xm1 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
BA [auth n]PF00137e6o7xn1 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
V [auth h]PF00137e6o7xh1 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
W [auth i]PF00137e6o7xi1 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
X [auth j]PF00137e6o7xj2 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
Z [auth l]PF00137e6o7xl2 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
U [auth g]PF00137e6o7xg2 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
Y [auth k]PF00137e6o7xk2 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
CA [auth o]PF00137e6o7xo1 A: extended segmentsX: F1F0 ATP synthase subunit C (From Topology)H: F1F0 ATP synthase subunit C (From Topology)T: F1F0 ATP synthase subunit CF: PF00137ECOD (1.6)
B [auth M]PF01813e6o7xM1 A: alpha bundlesX: V-type proton ATPase subunit D (From Topology)H: V-type proton ATPase subunit D (From Topology)T: V-type proton ATPase subunit DF: PF01813ECOD (1.6)
C [auth N]PF01990e6o7xN1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: AtpF-like (From Topology)T: AtpF-likeF: PF01990ECOD (1.6)
D [auth E]PF02874e6o7xE2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PF02874ECOD (1.6)
D [auth E]PF22919e6o7xE3 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: PF22919ECOD (1.6)
D [auth E]PF16886e6o7xE1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: PF16886ECOD (1.6)
D [auth E]PF00006,PF16886e6o7xE4 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00006,PF16886ECOD (1.6)
F [auth A]PF02874e6o7xA4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PF02874ECOD (1.6)
F [auth A]PF22919e6o7xA1 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: PF22919ECOD (1.6)
F [auth A]PF16886e6o7xA2 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: PF16886ECOD (1.6)
F [auth A]PF00006,PF16886e6o7xA3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00006,PF16886ECOD (1.6)
H [auth C]PF02874e6o7xC2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PF02874ECOD (1.6)
H [auth C]PF22919e6o7xC4 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: PF22919ECOD (1.6)
H [auth C]PF16886e6o7xC3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: PF16886ECOD (1.6)
H [auth C]PF00006,PF16886e6o7xC1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00006,PF16886ECOD (1.6)
E [auth F]PF02874e6o7xF1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PF02874ECOD (1.6)
E [auth F]PF22919e6o7xF2 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: PF22919ECOD (1.6)
E [auth F]PF00006e6o7xF3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00006ECOD (1.6)
I [auth D]PF02874e6o7xD3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PF02874ECOD (1.6)
I [auth D]PF22919e6o7xD1 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: PF22919ECOD (1.6)
I [auth D]PF00006e6o7xD2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00006ECOD (1.6)
G [auth B]PF02874e6o7xB3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PF02874ECOD (1.6)
G [auth B]PF22919e6o7xB2 A: alpha superhelicesX: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)T: C-terminal domain of alpha and beta subunits of F1 ATP synthaseF: PF22919ECOD (1.6)
G [auth B]PF00006e6o7xB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00006ECOD (1.6)
LPF03179e6o7xL1 A: extended segmentsX: V-type proton ATPase subunit G (From Topology)H: V-type proton ATPase subunit G (From Topology)T: V-type proton ATPase subunit GF: PF03179ECOD (1.6)
O [auth H]PF03179e6o7xH1 A: extended segmentsX: V-type proton ATPase subunit G (From Topology)H: V-type proton ATPase subunit G (From Topology)T: V-type proton ATPase subunit GF: PF03179ECOD (1.6)
JPF03179e6o7xJ1 A: extended segmentsX: V-type proton ATPase subunit G (From Topology)H: V-type proton ATPase subunit G (From Topology)T: V-type proton ATPase subunit GF: PF03179ECOD (1.6)
K [auth I]PF01991e6o7xI1 A: a+b two layersX: FwdE/GAPDH domain-likeH: V-type ATPase subunit E (From Topology)T: V-type ATPase subunit EF: PF01991ECOD (1.6)
K [auth I]PF01991e6o7xI2 A: extended segmentsX: Helical region in V-type proton ATPase subunit E (From Topology)H: Helical region in V-type proton ATPase subunit E (From Topology)T: Helical region in V-type proton ATPase subunit EF: PF01991ECOD (1.6)
M [auth K]PF01991e6o7xK1 A: a+b two layersX: FwdE/GAPDH domain-likeH: V-type ATPase subunit E (From Topology)T: V-type ATPase subunit EF: PF01991ECOD (1.6)
M [auth K]PF01991e6o7xK2 A: extended segmentsX: Helical region in V-type proton ATPase subunit E (From Topology)H: Helical region in V-type proton ATPase subunit E (From Topology)T: Helical region in V-type proton ATPase subunit EF: PF01991ECOD (1.6)
P [auth G]PF01991e6o7xG1 A: a+b two layersX: FwdE/GAPDH domain-likeH: V-type ATPase subunit E (From Topology)T: V-type ATPase subunit EF: PF01991ECOD (1.6)
P [auth G]PF01991e6o7xG2 A: extended segmentsX: Helical region in V-type proton ATPase subunit E (From Topology)H: Helical region in V-type proton ATPase subunit E (From Topology)T: Helical region in V-type proton ATPase subunit EF: PF01991ECOD (1.6)
N [auth P]PF03224,PF11698e6o7xP1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PF03224,PF11698ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth O]PF03223V-ATPase subunit C (V-ATPase_C)V-ATPase subunit C- Family
R [auth b]PF20520V0 complex accessory subunit Ac45/VOA1 transmembrane domain (Ac45-VOA1_TM)V0 complex accessory subunit Ac45/VOA1 transmembrane domainThis entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) whic ...This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function [1,2]. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities [3]. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.
Domain
S [auth c]PF00137ATP synthase subunit C (ATP-synt_C)ATP synthase subunit C- Family
T [auth d]PF01992ATP synthase (C/AC39) subunit (vATP-synt_AC39)ATP synthase (C/AC39) subunit- Family
PF00137ATP synthase subunit C (ATP-synt_C)ATP synthase subunit C- Family
CA [auth o]PF00137ATP synthase subunit C (ATP-synt_C)ATP synthase subunit C- Family
DA [auth e]PF05493ATP synthase subunit H (ATP_synt_H)ATP synthase subunit H- Family
B [auth M]PF01813ATP synthase subunit D (ATP-synt_D)ATP synthase subunit D- Family
C [auth N]PF01990ATP synthase (F/14-kDa) subunit (ATP-synt_F)ATP synthase (F/14-kDa) subunit- Family
D [auth E],
F [auth A],
H [auth C]		PF00006ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)ATP synthase alpha/beta family, nucleotide-binding domainThis entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.Domain
D [auth E],
F [auth A],
H [auth C]		PF16886ATPsynthase alpha/beta subunit N-term extension (ATP-synt_ab_Xtn)ATPsynthase alpha/beta subunit N-term extension- Family
D [auth E],
F [auth A],
H [auth C]		PF02874ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)ATP synthase alpha/beta family, beta-barrel domainThis family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.Domain
E [auth F],
G [auth B],
I [auth D]		PF00006ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)ATP synthase alpha/beta family, nucleotide-binding domainThis entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.Domain
E [auth F],
G [auth B],
I [auth D]		PF02874ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)ATP synthase alpha/beta family, beta-barrel domainThis family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.Domain
J,
L,
O [auth H]		PF03179Vacuolar (H+)-ATPase G subunit (V-ATPase_G)Vacuolar (H+)-ATPase G subunit- Coiled-coil
K [auth I],
M [auth K],
P [auth G]		PF01991ATP synthase (E/31 kDa) subunit (vATP-synt_E)ATP synthase (E/31 kDa) subunit- Family
N [auth P]PF11698V-ATPase subunit H (V-ATPase_H_C)V-ATPase subunit H- Repeat
N [auth P]PF03224V-ATPase subunit H (V-ATPase_H_N)V-ATPase subunit H- Repeat
Q [auth a]PF01496V-type ATPase 116kDa subunit family (V_ATPase_I)V-type ATPase 116kDa subunit family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth O]V-type proton ATPase subunit C
R [auth b]V0 assembly protein 1
S [auth c]V-type proton ATPase subunit c''
T [auth d]V-type proton ATPase subunit d
V-type proton ATPase subunit c
CA [auth o]V-type proton ATPase subunit c'
DA [auth e]V-type proton ATPase subunit e
EA [auth f]Putative protein YPR170W-B
B [auth M]V-type proton ATPase subunit D
C [auth N]V-type proton ATPase subunit F
D [auth E],
F [auth A],
H [auth C]		Vacuolar ATP synthase catalytic subunit A -
E [auth F],
G [auth B],
I [auth D]		V-type proton ATPase subunit B
J,
L,
O [auth H]		V-type proton ATPase subunit G
K [auth I],
M [auth K],
P [auth G]		V-type proton ATPase subunit E
N [auth P]V-type proton ATPase subunit H
Q [auth a]V-type proton ATPase subunit a, Golgi isoform

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth O]IPR036132Vacuolar ATP synthase subunit C superfamilyHomologous Superfamily
A [auth O]IPR004907ATPase, V1 complex, subunit CFamily
R [auth b]IPR046756V-type proton ATPase subunit S1/VOA1, transmembrane domainDomain
S [auth c]IPR035921F/V-ATP synthase subunit C superfamilyHomologous Superfamily
S [auth c]IPR002379V-ATPase proteolipid subunit C-like domainDomain
S [auth c]IPR000245V-ATPase proteolipid subunitFamily
T [auth d]IPR036079V-type ATP synthase subunit c/d subunit superfamilyHomologous Superfamily
T [auth d]IPR035067V-type ATPase subunit C/dHomologous Superfamily
T [auth d]IPR044911V-type ATP synthase c/d subunit, domain 3 superfamilyHomologous Superfamily
T [auth d]IPR016727ATPase, V0 complex, subunit dFamily
T [auth d]IPR002843ATPase, V0 complex, c/d subunitFamily
IPR035921F/V-ATP synthase subunit C superfamilyHomologous Superfamily
IPR002379V-ATPase proteolipid subunit C-like domainDomain
IPR011555V-ATPase proteolipid subunit C, eukaryoticFamily
IPR000245V-ATPase proteolipid subunitFamily
CA [auth o]IPR035921F/V-ATP synthase subunit C superfamilyHomologous Superfamily
CA [auth o]IPR002379V-ATPase proteolipid subunit C-like domainDomain
CA [auth o]IPR011555V-ATPase proteolipid subunit C, eukaryoticFamily
CA [auth o]IPR000245V-ATPase proteolipid subunitFamily
DA [auth e]IPR008389ATPase, V0 complex, subunit e1/e2Family
EA [auth f]IPR026770Ribonuclease kappaFamily
B [auth M]IPR002699ATPase, V1 complex, subunit DFamily
C [auth N]IPR036906ATPase, V1 complex, subunit F superfamilyHomologous Superfamily
C [auth N]IPR005772ATPase, V1 complex, subunit F, eukaryoticFamily
C [auth N]IPR008218ATPase, V1 complex, subunit FFamily
D [auth E],
F [auth A],
H [auth C]		IPR004100ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomain
D [auth E],
F [auth A],
H [auth C]		IPR022878V-type ATP synthase catalytic alpha chainFamily
D [auth E],
F [auth A],
H [auth C]		IPR031686ATPsynthase alpha/beta subunit, N-terminal extensionDomain
D [auth E],
F [auth A],
H [auth C]		IPR024034ATPase, F1/V1 complex, beta/alpha subunit, C-terminalHomologous Superfamily
D [auth E],
F [auth A],
H [auth C]		IPR036121ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamilyHomologous Superfamily
D [auth E],
F [auth A],
H [auth C]		IPR023366ATP synthase subunit alpha, N-terminal domain-like superfamilyHomologous Superfamily
D [auth E],
F [auth A],
H [auth C]		IPR020003ATPase, alpha/beta subunit, nucleotide-binding domain, active siteActive Site
D [auth E],
F [auth A],
H [auth C]		IPR000194ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomain
D [auth E],
F [auth A],
H [auth C]		IPR005725ATPase, V1 complex, subunit AFamily
D [auth E],
F [auth A],
H [auth C]		IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
E [auth F],
G [auth B],
I [auth D]		IPR000194ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomain
E [auth F],
G [auth B],
I [auth D]		IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
E [auth F],
G [auth B],
I [auth D]		IPR004100ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomain
E [auth F],
G [auth B],
I [auth D]		IPR005723ATPase, V1 complex, subunit BFamily
E [auth F],
G [auth B],
I [auth D]		IPR022879V-type ATP synthase regulatory subunit B/betaFamily
E [auth F],
G [auth B],
I [auth D]		IPR020003ATPase, alpha/beta subunit, nucleotide-binding domain, active siteActive Site
J,
L,
O [auth H]		IPR005124Vacuolar (H+)-ATPase G subunitFamily
K [auth I],
M [auth K],
P [auth G]		IPR002842V-type ATPase subunit EFamily
K [auth I],
M [auth K],
P [auth G]		IPR038495V-type ATPase subunit E, C-terminal domain superfamilyHomologous Superfamily
N [auth P]IPR004908ATPase, V1 complex, subunit HFamily
N [auth P]IPR016024Armadillo-type foldHomologous Superfamily
N [auth P]IPR011989Armadillo-like helicalHomologous Superfamily
N [auth P]IPR038497ATPase, V1 complex, subunit H, C-terminal domain superfamilyHomologous Superfamily
N [auth P]IPR011987ATPase, V1 complex, subunit H, C-terminalDomain
Q [auth a]IPR026028ATPase, V0 complex, subunit 116kDa, eukaryoticFamily
Q [auth a]IPR002490V-type ATPase, V0 complex, 116kDa subunit familyFamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALVacuolar ATPase (V-ATPase)V-ATPase, Vph1-VO isoform