6NT2

type 1 PRMT in complex with the inhibitor GSK3368715

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth B]	d6nt2b_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Arginine methyltransferase	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth C]	d6nt2c_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Arginine methyltransferase	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6nt2a_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Arginine methyltransferase	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth D]	d6nt2d_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Arginine methyltransferase	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth B]	PF22528	e6nt2B2	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: PF22528	ECOD (1.6)
C [auth B]	PF13649	e6nt2B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF13649	ECOD (1.6)
D [auth C]	PF22528	e6nt2C1	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: PF22528	ECOD (1.6)
D [auth C]	PF13649	e6nt2C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF13649	ECOD (1.6)
A	PF22528	e6nt2A1	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: PF22528	ECOD (1.6)
A	PF13649	e6nt2A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF13649	ECOD (1.6)
B [auth D]	PF22528	e6nt2D1	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: PF22528	ECOD (1.6)
B [auth D]	PF13649	e6nt2D2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF13649	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth B]	2.70.160.11	Mainly Beta	Distorted Sandwich	Hnrnp arginine n-methyltransferase1	Hnrnp arginine n-methyltransferase1	CATH (utative)
D [auth C]	2.70.160.11	Mainly Beta	Distorted Sandwich	Hnrnp arginine n-methyltransferase1	Hnrnp arginine n-methyltransferase1	CATH (utative)
A	2.70.160.11	Mainly Beta	Distorted Sandwich	Hnrnp arginine n-methyltransferase1	Hnrnp arginine n-methyltransferase1	CATH (utative)
B [auth D]	2.70.160.11	Mainly Beta	Distorted Sandwich	Hnrnp arginine n-methyltransferase1	Hnrnp arginine n-methyltransferase1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth B], D [auth C]	PF13649	Methyltransferase domain (Methyltransf_25)	Methyltransferase domain	This family appears to be a methyltransferase domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth B], D [auth C]	Protein arginine N-methyltransferase 1	catalytic activity, acting on a protein transferase activity, transferring one-carbon groups arginine N-methyltransferase activity protein methyltransferase activity N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine N-methyltransferase activity cation binding binding ion binding S-adenosyl-L-methionine binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups arginine N-methyltransferase activity protein methyltransferase activity N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine N-methyltransferase activity cation binding binding ion binding S-adenosyl-L-methionine binding sulfur compound binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding histone H4 methyltransferase activity histone methyltransferase activity histone H4R3 methyltransferase activity histone modifying activity protein binding kinase binding enzyme binding mitogen-activated protein kinase p38 binding protein kinase binding mitogen-activated protein kinase binding protein-arginine omega-N monomethyltransferase activity sequence-specific DNA binding DNA binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding methyl-CpG binding protein-arginine omega-N asymmetric methyltransferase activity identical protein binding	viral gene expression viral protein processing viral process regulation of cellular process positive regulation of protein metabolic process cellular biosynthetic process positive regulation of biological process organonitrogen compound biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of hemoglobin biosynthetic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process viral gene expression viral protein processing viral process regulation of cellular process positive regulation of protein metabolic process cellular biosynthetic process positive regulation of biological process organonitrogen compound biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of hemoglobin biosynthetic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process hemoglobin metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process hemoglobin biosynthetic process regulation of protein metabolic process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process macromolecule biosynthetic process regulation of cellular biosynthetic process biosynthetic process regulation of hemoglobin biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication negative regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus regulation of JNK cascade regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus MAPK cascade regulation of cell communication negative regulation of MAPK cascade cellular developmental process regulation of developmental process regulation of megakaryocyte differentiation megakaryocyte differentiation cell development regulation of cell differentiation regulation of cell development negative regulation of megakaryocyte differentiation cell differentiation negative regulation of cell differentiation regulation of immune system process regulation of multicellular organismal process regulation of multicellular organismal development hemopoiesis negative regulation of developmental process regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation myeloid cell differentiation immune system process regulation of hemopoiesis cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of translation post-transcriptional regulation of gene expression gene expression translation regulation of gene expression positive regulation of gene expression regulation of translation cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway cellular response to endogenous stimulus BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor RNA splicing RNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA processing homeostatic process positive regulation of developmental process positive regulation of cell differentiation myeloid cell homeostasis erythrocyte homeostasis erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis positive regulation of myeloid cell differentiation homeostasis of number of cells protein methylation macromolecule methylation protein alkylation methylation macromolecule modification protein modification process positive regulation of cell communication positive regulation of signal transduction p38MAPK cascade positive regulation of response to stimulus positive regulation of MAPK cascade positive regulation of intracellular signal transduction positive regulation of p38MAPK cascade regulation of p38MAPK cascade positive regulation of signaling heart development cardiac muscle tissue development animal organ development tissue development striated muscle tissue development circulatory system development muscle tissue development system development cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis peptidyl-arginine methylation peptidyl-amino acid modification peptidyl-arginine modification plasma membrane bounded cell projection organization cell projection organization neuron projection development nervous system development generation of neurons neurogenesis neuron differentiation neuron development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex catalytic complex methylosome methyltransferase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth B], D [auth C]	IPR025799	Protein arginine N-methyltransferase	Family
A, B [auth D], C [auth B], D [auth C]	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B [auth D], C [auth B], D [auth C]	IPR041698	Methyltransferase domain 25	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth D], C [auth B], D [auth C]	Pharos: Q99873	dermatomyositis Hodgkins lymphoma lung cancer myositis rheumatoid arthritis systemic sclerosis diabetes mellitus hypothyroidism malignant colon neoplasm ovarian cancer skin basal cell carcinoma vitiligo Hashimoto thyroiditis large cell medulloblastoma medulloblastoma dermatomyositis Hodgkins lymphoma lung cancer myositis rheumatoid arthritis systemic sclerosis diabetes mellitus hypothyroidism malignant colon neoplasm ovarian cancer skin basal cell carcinoma vitiligo Hashimoto thyroiditis large cell medulloblastoma medulloblastoma psoriasis systemic lupus erythematosus

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.