6NR2

Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2

External Resource: Annotation

Domain Annotation: ECOD Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6nr2A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00520	e6nr2A1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
A	PF18139	e6nr2A3	A: a/b three-layered sandwiches	X: MCP/YpsA-related (From Topology)	H: MCP/YpsA-related (From Topology)	T: MCP/YpsA-related	F: PF18139	ECOD (1.6)
B	F_UNCLASSIFIED	e6nr2B2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00520	e6nr2B1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
B	PF18139	e6nr2B3	A: a/b three-layered sandwiches	X: MCP/YpsA-related (From Topology)	H: MCP/YpsA-related (From Topology)	T: MCP/YpsA-related	F: PF18139	ECOD (1.6)
C	F_UNCLASSIFIED	e6nr2C2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00520	e6nr2C1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
C	PF18139	e6nr2C3	A: a/b three-layered sandwiches	X: MCP/YpsA-related (From Topology)	H: MCP/YpsA-related (From Topology)	T: MCP/YpsA-related	F: PF18139	ECOD (1.6)
D	F_UNCLASSIFIED	e6nr2D2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00520	e6nr2D1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
D	PF18139	e6nr2D3	A: a/b three-layered sandwiches	X: MCP/YpsA-related (From Topology)	H: MCP/YpsA-related (From Topology)	T: MCP/YpsA-related	F: PF18139	ECOD (1.6)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.