6NQ3

Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	WD40 repeat-like	8053350	3001694	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	WD40 repeat-like	8053350	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00400,PF12265	e6nq3A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400,PF12265	ECOD (1.6)
E	PF00400,PF12265	e6nq3E1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400,PF12265	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (utative)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E	PF12265	Histone-binding protein RBBP4 or subunit C of CAF1 complex (CAF1C_H4-bd)	Histone-binding protein RBBP4 or subunit C of CAF1 complex	-	Repeat
A, E	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
C, G	PF14061	Polycomb-like MTF2 factor 2 (Mtf2_C)	Polycomb-like MTF2 factor 2	Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression [1]. The human MTF2 gene is expressed in three splicing variants, each of them co ...	Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression [1]. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E	Histone-binding protein RBBP4	protein binding binding histone binding histone deacetylase binding enzyme binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding protein binding binding histone binding histone deacetylase binding enzyme binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process DNA replication DNA metabolic process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of developmental process cellular developmental process regulation of cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation regulation of cell fate commitment cell fate specification regulation of cell fate specification cell fate commitment positive regulation of biological process regulation of stem cell population maintenance stem cell population maintenance positive regulation of developmental process positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number cell cycle protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular component organization or biogenesis nucleosome assembly nucleosome organization cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway DNA replication-dependent chromatin assembly negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process negative regulation of developmental process negative regulation of stem cell population maintenance negative regulation of multicellular organismal process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II	protein-containing complex CAF-1 complex membrane-bounded organelle intracellular anatomical structure Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex chromosome intracellular organelle lumen histone deacetylase complex intracellular organelle nucleoplasm protein-containing complex CAF-1 complex membrane-bounded organelle intracellular anatomical structure Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex chromosome intracellular organelle lumen histone deacetylase complex intracellular organelle nucleoplasm non-membrane-bounded organelle catalytic complex protein-DNA complex chromatin intracellular membrane-bounded organelle cellular anatomical entity organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen cytoplasm cytosol histone methyltransferase complex transferase complex PcG protein complex methyltransferase complex ESC/E(Z) complex ATPase complex transcription regulator complex NuRD complex SWI/SNF superfamily-type complex CHD-type complex chromosome, telomeric region chromosomal region NURF complex ISWI-type complex
B, F	Polycomb protein SUZ12	transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding RNA binding organic cyclic compound binding lncRNA binding nucleic acid binding DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding RNA binding organic cyclic compound binding lncRNA binding nucleic acid binding DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding promoter-specific chromatin binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity transferase activity methyltransferase activity catalytic activity histone methyltransferase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity chromatin DNA binding methylated histone binding modification-dependent protein binding histone binding methylation-dependent protein binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process cellular developmental process nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development cellular process system development developmental process multicellular organismal process cellular developmental process nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development cellular process system development cell population proliferation regulation of biological process regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process facultative heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of developmental process negative regulation of developmental process regulation of cell differentiation negative regulation of cell differentiation regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process random inactivation of X chromosome sex-chromosome dosage compensation dosage compensation by inactivation of X chromosome	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle RSC-type complex ATPase complex protein-containing complex catalytic complex protein-DNA complex nuclear protein-containing complex chromatin chromosome SWI/SNF superfamily-type complex sex chromosome heterochromatin sex chromatin histone methyltransferase complex transferase complex PcG protein complex nucleoplasm methyltransferase complex ESC/E(Z) complex chromatin silencing complex ribonucleoprotein complex nuclear body
C, G	PHD finger protein 19	DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding methylated histone binding protein binding modification-dependent protein binding histone binding methylation-dependent protein binding cation binding ion binding metal ion binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding methylated histone binding protein binding modification-dependent protein binding histone binding methylation-dependent protein binding cation binding ion binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process developmental process multicellular organismal process maintenance of cell number stem cell population maintenance negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process stem cell differentiation cellular developmental process cell differentiation protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen PcG protein complex intracellular organelle membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen PcG protein complex intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex ESC/E(Z) complex nuclear lumen
D, H	Protein Jumonji	protein-containing complex binding chromatin binding binding protein binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity modification-dependent protein binding protein-macromolecule adaptor activity ubiquitin-like protein reader activity protein-containing complex binding chromatin binding binding protein binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity modification-dependent protein binding protein-macromolecule adaptor activity ubiquitin-like protein reader activity molecular adaptor activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone H3K27 methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development immune system development hematopoietic or lymphoid organ development thymus development immune system process central nervous system development developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development immune system development hematopoietic or lymphoid organ development thymus development immune system process central nervous system development nervous system development heart development heart growth cell population proliferation developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth organ growth tissue development striated muscle tissue development circulatory system development muscle cell proliferation cellular process cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to pericentric heterochromatin protein localization to heterochromatin regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of growth regulation of cardiac muscle tissue growth regulation of developmental process negative regulation of biological process negative regulation of cardiac muscle tissue growth negative regulation of organ growth negative regulation of growth regulation of organ growth regulation of heart growth negative regulation of cellular process regulation of cardiac muscle cell proliferation regulation of multicellular organismal process negative regulation of cell population proliferation regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth negative regulation of developmental process negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation spleen development negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process facultative heterochromatin formation negative regulation of gene expression, epigenetic muscle hypertrophy regulation of muscle adaptation system process negative regulation of muscle hypertrophy response to stimulus regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation regulation of response to stimulus cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process stem cell differentiation cellular developmental process cell differentiation random inactivation of X chromosome sex-chromosome dosage compensation dosage compensation by inactivation of X chromosome cellular response to stimulus response to organic substance response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen PcG protein complex ESC/E(Z) complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E	IPR019775	WD40 repeat, conserved site	Conserved Site
A, E	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, E	IPR022052	Histone-binding protein RBBP4, N-terminal	Domain
A, E	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, E	IPR001680	WD40 repeat	Repeat
A, E	IPR020472	G-protein beta WD-40 repeat	Repeat
B, F	IPR019135	Polycomb protein, VEFS-Box	Domain
C, G	IPR047400	PHD finger protein 19, Tudor domain	Domain
C, G	IPR025894	Polycomb-like MTF2 factor 2, C-terminal domain	Domain
C, G	IPR001965	Zinc finger, PHD-type	Domain
C, G	IPR002999	Tudor domain	Domain
C, G	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
C, G	IPR019787	Zinc finger, PHD-finger	Domain
C, G	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
C, G	IPR042017	PHF19, PHD domain 2	Domain
C, G	IPR040477	Lysine-specific demethylase 4-like, Tudor domain	Domain
C, G	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
D, H	IPR003347	JmjC domain	Domain
D, H	IPR003349	JmjN domain	Domain
D, H	IPR001606	ARID DNA-binding domain	Domain
D, H	IPR004198	Zinc finger, C5HC2-type	Domain
D, H	IPR036431	ARID DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E	Pharos: Q09028	medulloblastoma Pick disease osteosarcoma subependymal giant cell astrocytoma ovarian cancer
B, F	Pharos: Q15022	malignant glioma endometrioid stromal sarcoma schwannoma melanoma neurofibroma cancer glioblastoma mixed glioma adenoma perineurioma endometrial carcinoma giant cell glioblastoma malignant peripheral nerve sheath tumor microcystic adenoma papillary adenoma malignant glioma endometrioid stromal sarcoma schwannoma melanoma neurofibroma cancer glioblastoma mixed glioma adenoma perineurioma endometrial carcinoma giant cell glioblastoma malignant peripheral nerve sheath tumor microcystic adenoma papillary adenoma follicular thyroid adenoma glioma melanocytic nevus Nerve Sheath Tumors breast cancer ovarian cancer cystic fibrosis Pick disease lung cancer myopathy astrocytic tumor oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma dermatomyositis plasma cell myeloma endometrium neoplasm malignant ependymoma medulloblastoma nerve sheath neoplasm neurofibromatosis osteosarcoma cutaneous melanoma endometrial cancer peripheral nervous system neoplasm progressive supranuclear palsy Weaver syndrome
C, G	Pharos: Q5T6S3	rheumatoid arthritis allergic rhinitis lung adenocarcinoma non-small cell lung carcinoma psoriasis breast cancer malignant glioma osteosarcoma glioblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis
D, H	Pharos: Q92833	autism spectrum disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia schizophrenia tuberculosis Autism Spectrum Disorders ovarian cancer plasma cell myeloma squamous cell carcinoma lung cancer pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma