Annotations: 6NQ1

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6nq1A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00520	e6nq1A2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
B	F_UNCLASSIFIED	e6nq1B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00520	e6nq1B1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Two pore calcium channel protein 2	monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity channel activity intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity channel activity intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity calcium channel activity voltage-gated calcium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity calcium ion transmembrane transporter activity protein binding kinase binding enzyme binding protein kinase binding NAADP-sensitive calcium-release channel activity intracellularly gated calcium channel activity ligand-gated calcium channel activity identical protein binding	import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization biological process involved in interaction with host vesicle-mediated transport biological process involved in symbiotic interaction localization symbiont entry into host cell viral process symbiont entry into host cellular process import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization biological process involved in interaction with host vesicle-mediated transport biological process involved in symbiotic interaction localization symbiont entry into host cell viral process symbiont entry into host cellular process endocytosis involved in viral entry into host cell endocytosis receptor-mediated endocytosis transport of virus multicellular organismal process system process smooth muscle contraction muscle contraction muscle system process transmembrane transport monoatomic ion transmembrane transport monoatomic ion transport inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction cellular component organization lysosome organization organelle organization vacuole organization lytic vacuole organization cellular component organization or biogenesis intracellular pH reduction regulation of intracellular pH regulation of pH regulation of biological quality regulation of cellular pH sodium ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport monoatomic cation transmembrane transport monoatomic cation transport sodium ion transport pigmentation negative regulation of developmental pigmentation developmental pigmentation negative regulation of biological process regulation of developmental pigmentation regulation of pigmentation regulation of localization cellular localization negative regulation of sequestering of calcium ion calcium ion transport maintenance of location in cell negative regulation of cellular process regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol sequestering of calcium ion maintenance of location release of sequestered calcium ion into cytosol calcium ion transmembrane transport response to nutrient levels response to organic substance response to vitamin D response to lipid response to chemical response to nutrient response to oxygen-containing compound response to vitamin response to organic cyclic compound regulation of transport secretion export from cell regulation of vesicle-mediated transport regulation of secretion regulation of secretion by cell secretion by cell exocytosis regulation of exocytosis catabolic process cellular metabolic process autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy cellular catabolic process regulation of cellular catabolic process metabolic process regulation of metabolic process process utilizing autophagic mechanism endosome to lysosome transport intracellular cholesterol transport vesicle-mediated cholesterol transport organic hydroxy compound transport lysosomal transport intracellular sterol transport establishment of localization in cell sterol transport intracellular lipid transport endosome to lysosome transport of low-density lipoprotein particle organic substance transport lipid localization intracellular transport lipid transport cytosolic transport macromolecule localization vacuolar transport cholesterol transport	endosome membrane membrane-bounded organelle intracellular anatomical structure endolysosome membrane intracellular vesicle lytic vacuole endomembrane system intracellular organelle bounding membrane of organelle endolysosome vesicle membrane cytoplasmic vesicle vesicle lysosome endosome membrane membrane-bounded organelle intracellular anatomical structure endolysosome membrane intracellular vesicle lytic vacuole endomembrane system intracellular organelle bounding membrane of organelle endolysosome vesicle membrane cytoplasmic vesicle vesicle lysosome vacuolar membrane membrane endosome vacuole cellular anatomical entity intracellular membrane-bounded organelle lytic vacuole membrane cytoplasmic vesicle membrane organelle lysosomal membrane cytoplasm organelle membrane cytosol late endosome membrane late endosome protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex pigment granule chitosome melanosome melanosome membrane pigment granule membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR028798	Two pore channel protein 2	Family
A, B	IPR005821	Ion transport domain	Domain
A, B	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8NHX9	acute coronary syndrome breast carcinoma large cell medulloblastoma ovarian cancer Paroxysmal supraventricular tachycardia prostate carcinoma melanoma ovarian carcinoma atrial fibrillation hypertensive disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Prinzmetal angina

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	Two-pore channel TPC2, apo state

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.