Annotations: 6NMI

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RecA-like P-loop NTPases	8054245	3002019	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	BSD domain-like	8039783	3001039	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	vWA-like	8057086	3000832	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Cysteine-rich domain	8033482	3001452	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	vWA-like	8054198	3000832	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	TFB5-like	8034306	3000733	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	RING/U-box like	8039298	3000160	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	PF04056	e6nmiE3	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF04056	ECOD (1.6)
E	F_UNCLASSIFIED	e6nmiE2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF07975	e6nmiE1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: Cysteine-rich domain	F: PF07975	ECOD (1.6)
F	PF03850	e6nmiF1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF03850	ECOD (1.6)
F	PF03850	e6nmiF2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF03850	ECOD (1.6)
G	PF06331	e6nmiG1	A: a+b complex topology	X: TFB5-related (From Topology)	H: TFB5-related (From Topology)	T: TFB5-related	F: PF06331	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G	3.30.70.1220	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	TFB5-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13625	Helicase conserved C-terminal domain (Helicase_C_3)	Helicase conserved C-terminal domain	This domain family is found in a wide variety of helicases and helicase-related proteins.	Domain
A	PF04851	Type III restriction enzyme, res subunit (ResIII)	Type III restriction enzyme, res subunit	-	Family
A	PF16203	ERCC3/RAD25/XPB C-terminal helicase (ERCC3_RAD25_C)	ERCC3/RAD25/XPB C-terminal helicase	This is the C-terminal helicase domain of ERCC3, RAD25 and XPB helicases [1].	Domain
B	PF13307	Helicase C-terminal domain (Helicase_C_2)	Helicase C-terminal domain	This domain is found at the C-terminus of DEAD-box helicases.	Domain
B	PF06733	DEAD_2 (DEAD_2)	DEAD_2	-	Family
B	PF06777	Helical and beta-bridge domain (HBB)	Helical and beta-bridge domain	HBB is the domain on DEAD-box eukaryotic DNA repair helicases (EC:3.6.1.-) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein ...	HBB is the domain on DEAD-box eukaryotic DNA repair helicases (EC:3.6.1.-) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping architecture [1]. This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).	Domain
D	PF03849	Transcription factor Tfb2 (Tfb2)	Transcription factor Tfb2	-	Family
D	PF18307	Transcription factor Tfb2 (p52) C-terminal domain (Tfb2_C)	Transcription factor Tfb2 (p52) C-terminal domain	This is the C-terminal domain of Transcription factor Tfb2 present in Saccharomyces cerevisiae. Tfb2 is referred to as p52 in humans. The interaction between p8-Tfb5 and p52-Tfb2 has a key role in the maintenance of the transcription factor TFIIH arc ...	This is the C-terminal domain of Transcription factor Tfb2 present in Saccharomyces cerevisiae. Tfb2 is referred to as p52 in humans. The interaction between p8-Tfb5 and p52-Tfb2 has a key role in the maintenance of the transcription factor TFIIH architecture and TFIIHs function in nucleotide-excision repair (NER) pathway. The C-terminal domain of Tfb2 is thought to have a crucial role in DNA repair [1].	Domain
E	PF04056	Ssl1-like (Ssl1)	Ssl1-like	-	Family
E	PF07975	TFIIH C1-like domain (C1_4)	TFIIH C1-like domain	The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD ...	The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (Pfam:PF00130) [1].	Domain
F	PF03850	Transcription factor Tfb4 (Tfb4)	Transcription factor Tfb4	This family appears to be distantly related to the VWA domain.	Domain
G	PF06331	Transcription factor TFIIH complex subunit Tfb5 (Tfb5)	Transcription factor TFIIH complex subunit Tfb5	-	Family
H	PF17121	Zinc finger, C3HC4 type (RING finger) (zf-C3HC4_5)	Zinc finger, C3HC4 type (RING finger)	-	Domain
H	PF06391	CDK-activating kinase assembly factor MAT1 (MAT1)	CDK-activating kinase assembly factor MAT1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	General transcription and DNA repair factor IIH helicase subunit XPB	DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity	developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process apoptotic process cell death programmed cell death regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process chromosome organization DNA conformation change DNA metabolic process cellular component organization DNA topological change organelle organization cellular component organization or biogenesis cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair response to light stimulus response to radiation response to abiotic stimulus response to UV UV protection animal organ development embryonic organ development embryo development DNA geometric change DNA duplex unwinding nucleotide-excision repair, DNA duplex unwinding regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process cell cycle regulation of cell cycle mitotic cell cycle phase transition cell cycle process transcription initiation at RNA polymerase II promoter DNA-templated transcription initiation response to decreased oxygen levels response to hypoxia response to oxygen levels transcription elongation by RNA polymerase II DNA-templated transcription elongation response to oxidative stress	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex nucleotide-excision repair factor 3 complex nucleotide-excision repair complex
B	General transcription and DNA repair factor IIH helicase subunit XPD	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding cation binding metal ion binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA 5'-3' DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity DNA binding damaged DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organism development multicellular organismal process embryonic cleavage cell division developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organism development multicellular organismal process embryonic cleavage cell division embryo development ossification bone mineralization animal organ development biomineral tissue development tissue development cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction by p53 class mediator cell death intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death cell cycle chromosome segregation cell cycle process cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization transcription-coupled nucleotide-excision repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development embryonic organ development regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process regulation of cell cycle mitotic cell cycle phase transition response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus regulation of DNA recombination positive regulation of biological process positive regulation of mitotic recombination regulation of mitotic recombination regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination mitotic recombination regulation of macromolecule metabolic process positive regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process multicellular organism growth developmental growth growth cellular component assembly involved in morphogenesis glial cell development myelin assembly cellular component biogenesis neurogenesis cellular anatomical entity morphogenesis cellular component assembly gliogenesis axon ensheathment ensheathment of neurons system development oligodendrocyte development central nervous system myelination nervous system development central nervous system myelin formation myelination anatomical structure morphogenesis axon ensheathment in central nervous system central nervous system development oligodendrocyte differentiation glial cell differentiation anatomical structure formation involved in morphogenesis epithelium development epidermal cell differentiation epidermis development epithelial cell differentiation hair cell differentiation generation of neurons neuron differentiation spinal cord development ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis maturation of SSU-rRNA organic substance biosynthetic process RNA processing rRNA metabolic process cellular metabolic process gene expression macromolecule biosynthetic process ribosomal small subunit biogenesis biosynthetic process nucleic acid catabolic process nucleobase-containing compound biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic cyclic compound biosynthetic process response to light stimulus response to radiation response to UV UV protection determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation molting cycle process hair cycle developmental maturation skin development anatomical structure maturation skin epidermis development hair follicle development molting cycle hair cycle process hair follicle maturation response to oxidative stress transcription elongation by RNA polymerase I transcription by RNA polymerase I rRNA transcription nucleolar large rRNA transcription by RNA polymerase I DNA-templated transcription elongation post-embryonic development erythrocyte development homeostatic process erythrocyte maturation erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process myeloid cell development homeostasis of number of cells myeloid cell homeostasis cell maturation erythrocyte homeostasis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle organelle RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle CAK-ERCC2 complex protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex MMXD complex
C	General transcription factor IIH subunit 1, p62	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding nuclear thyroid hormone receptor binding protein binding binding DNA-binding transcription factor binding protein-containing complex binding chromatin binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process transcription by RNA polymerase I organic cyclic compound biosynthetic process organic substance biosynthetic process transcription by RNA polymerase II regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to organic substance signaling response to endogenous stimulus hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical signal transduction cellular response to organic substance cellular response to hormone stimulus nucleotide-excision repair regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of cyclin-dependent protein kinase activity regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process cell cycle phosphorus metabolic process protein modification process regulation of cell cycle organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of protein kinase activity regulation of molecular function regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle RNA polymerase II, holoenzyme membrane-enclosed lumen RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen protein kinase complex nucleoplasm transcription factor TFIIH holo complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen carboxy-terminal domain protein kinase complex RNA polymerase complex serine/threonine protein kinase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
D	General transcription factor IIH subunit 4, p52	DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process nucleotide-excision repair	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex protein kinase complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
E	General transcription factor IIH subunit 2, p44	general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process response to light stimulus response to stimulus response to radiation response to abiotic stimulus response to UV cellular response to stimulus DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair regulation of cellular process regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative adaptation of signaling pathway import into cell receptor internalization negative regulation of signaling signaling transport negative regulation of biological process desensitization of G protein-coupled receptor signaling pathway regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication vesicle-mediated transport cell communication localization negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor internalization regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction establishment of localization regulation of response to stimulus adaptation of signaling pathway regulation of cell communication G protein-coupled receptor signaling pathway receptor-mediated endocytosis endocytosis positive regulation of organelle organization regulation of ATP-dependent activity regulation of cellular component organization positive regulation of cellular component organization regulation of catalytic activity positive regulation of helicase activity positive regulation of ATP-dependent activity DNA geometric change positive regulation of biological process DNA conformation change cellular component organization positive regulation of molecular function positive regulation of DNA duplex unwinding cellular component organization or biogenesis positive regulation of cellular process DNA duplex unwinding chromosome organization positive regulation of catalytic activity regulation of chromosome organization regulation of DNA duplex unwinding regulation of organelle organization positive regulation of chromosome organization positive regulation of DNA helicase activity regulation of helicase activity regulation of molecular function organelle organization regulation of DNA helicase activity	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex protein kinase complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
F	General transcription factor IIH subunit 3, p34	general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity cation binding ion binding binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cellular response to stimulus response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair transcription by RNA polymerase II nucleotide-excision repair	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle transcription preinitiation complex protein-DNA complex RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen protein kinase complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
G	General transcription factor IIH subunit 5, p8	-	cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process ribonucleoprotein complex biogenesis rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis ribosome biogenesis maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process ribosomal small subunit biogenesis nucleic acid catabolic process cellular response to stimulus response to stimulus cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair transcription elongation by RNA polymerase I transcription by RNA polymerase I rRNA transcription nucleolar large rRNA transcription by RNA polymerase I DNA-templated transcription elongation cellular component organization protein-DNA complex organization cellular component assembly protein-containing complex assembly protein-containing complex organization nucleotide-excision repair, preincision complex assembly protein-DNA complex assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex cytoplasm protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex
H	CDK-activating kinase assembly factor MAT1	cyclin-dependent protein serine/threonine kinase activator activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity cyclin-dependent protein serine/threonine kinase regulator activity molecular function regulator activity protein kinase activator activity kinase regulator activity cation binding transition metal ion binding zinc ion binding cyclin-dependent protein serine/threonine kinase activator activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity cyclin-dependent protein serine/threonine kinase regulator activity molecular function regulator activity protein kinase activator activity kinase regulator activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of cellular component organization regulation of cellular process regulation of catalytic activity negative regulation of biological process DNA geometric change cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of cellular component organization regulation of cellular process regulation of catalytic activity negative regulation of biological process DNA geometric change negative regulation of catalytic activity DNA conformation change negative regulation of chromosome organization negative regulation of DNA duplex unwinding negative regulation of cellular process negative regulation of helicase activity negative regulation of DNA helicase activity DNA duplex unwinding regulation of biological process negative regulation of cellular component organization biological regulation negative regulation of molecular function chromosome organization regulation of chromosome organization regulation of DNA duplex unwinding regulation of organelle organization regulation of helicase activity regulation of molecular function organelle organization regulation of DNA helicase activity negative regulation of organelle organization response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process cellular response to stimulus DNA metabolic process cellular response to stress DNA damage response response to stress DNA repair mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation positive regulation of biological process smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation positive regulation of cellular process nucleotide-excision repair regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development adult heart development circulatory system development system development regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle G1/S phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle regulation of cell cycle head development brain development nervous system development central nervous system development ventricular system development	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle RNA polymerase II, holoenzyme membrane-enclosed lumen RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription factor TFIIH core complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle RNA polymerase II, holoenzyme membrane-enclosed lumen transferase complex intracellular organelle lumen protein kinase complex nucleoplasm transcription factor TFIIH holo complex catalytic complex transferase complex, transferring phosphorus-containing groups transcription factor TFIIK complex nuclear DNA-directed RNA polymerase complex organelle lumen carboxy-terminal domain protein kinase complex RNA polymerase complex serine/threonine protein kinase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen CAK-ERCC2 complex cyclin-dependent protein kinase holoenzyme complex cyclin-dependent protein kinase activating kinase holoenzyme complex enzyme activator complex nuclear cyclin-dependent protein kinase holoenzyme complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032830	Helicase XPB/Ssl2, N-terminal domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR006935	Helicase/UvrB, N-terminal	Domain
A	IPR001650	Helicase, C-terminal domain-like	Domain
A	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A	IPR032438	ERCC3/RAD25/XPB helicase, C-terminal domain	Domain
A	IPR001161	Helicase XPB/Ssl2	Family
B	IPR001945	RAD3/XPD family	Family
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR006554	Helicase-like, DEXD box c2 type	Domain
B	IPR010614	RAD3-like helicase, DEAD	Domain
B	IPR013020	ATP-dependent helicase Rad3/Chl1-like	Family
B	IPR010643	Helical and beta-bridge domain	Domain
B	IPR045028	Helicase superfamily 1/2, DinG/Rad3-like	Family
B	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Conserved Site
B	IPR006555	ATP-dependent helicase, C-terminal	Domain
B	IPR014013	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type	Domain
C	IPR013876	TFIIH p62 subunit, N-terminal	Domain
C	IPR035925	BSD domain superfamily	Homologous Superfamily
C	IPR027079	TFIIH subunit Tfb1/GTF2H1	Family
C	IPR011993	PH-like domain superfamily	Homologous Superfamily
C	IPR005607	BSD domain	Domain
D	IPR040662	Transcription factor Tfb2, C-terminal domain	Domain
D	IPR004598	Transcription factor TFIIH subunit p52/Tfb2	Family
E	IPR007198	Ssl1-like	Domain
E	IPR012170	TFIIH subunit Ssl1/p44	Family
E	IPR004595	TFIIH C1-like domain	Domain
E	IPR013087	Zinc finger C2H2-type	Domain
E	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
E	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
E	IPR002035	von Willebrand factor, type A	Domain
E	IPR046349	C1-like domain superfamily	Homologous Superfamily
F	IPR004600	TFIIH subunit Tfb4/GTF2H3	Family
F	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
G	IPR009400	TFIIH subunit TTDA/Tfb5	Family
G	IPR035935	TFB5-like superfamily	Homologous Superfamily
H	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
H	IPR004575	Cdk-activating kinase assembly factor MAT1/Tfb3	Family
H	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
H	IPR015877	Cdk-activating kinase assembly factor MAT1, centre	Domain
H	IPR003903	Ubiquitin interacting motif	Conserved Site
H	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P19447	xeroderma pigmentosum trichothiodystrophy 2, photosensitive xeroderma pigmentosum group B trichothiodystrophy Cockayne syndrome peripheral nervous system disease peripheral neuropathy Arsenic Poisoning photosensitive trichothiodystrophy squamous cell carcinoma cutaneous melanoma lung cancer Pick disease xeroderma pigmentosum-Cockayne syndrome complex cataract xeroderma pigmentosum trichothiodystrophy 2, photosensitive xeroderma pigmentosum group B trichothiodystrophy Cockayne syndrome peripheral nervous system disease peripheral neuropathy Arsenic Poisoning photosensitive trichothiodystrophy squamous cell carcinoma cutaneous melanoma lung cancer Pick disease xeroderma pigmentosum-Cockayne syndrome complex cataract intellectual disability osteosarcoma skin basal cell carcinoma trichothiodystrophy 1, photosensitive leukodystrophy melanoma ovarian cancer
B	Pharos: P18074	xeroderma pigmentosum photosensitive trichothiodystrophy cerebrooculofacioskeletal syndrome 2 skin neoplasm trichothiodystrophy Cockayne syndrome xeroderma pigmentosum group D squamous cell carcinoma sunburn prostate cancer cataract Occupational Diseases skin cancer trichothiodystrophy 1, photosensitive COFS syndrome xeroderma pigmentosum photosensitive trichothiodystrophy cerebrooculofacioskeletal syndrome 2 skin neoplasm trichothiodystrophy Cockayne syndrome xeroderma pigmentosum group D squamous cell carcinoma sunburn prostate cancer cataract Occupational Diseases skin cancer trichothiodystrophy 1, photosensitive COFS syndrome epidermolytic hyperkeratosis urinary bladder cancer colorectal cancer leukodystrophy peripheral nervous system disease skin basal cell carcinoma bladder benign neoplasm urinary bladder carcinoma colorectal carcinoma gastric neoplasm peripheral neuropathy bladder carcinoma in situ cerebrooculofacioskeletal syndrome 1 urinary bladder neoplasm xeroderma pigmentosum-Cockayne syndrome complex hereditary diffuse gastric adenocarcinoma intellectual disability melanoma skin disease cutaneous melanoma gastric cancer
C	Pharos: P32780	attention deficit hyperactivity disorder, inattentive type gastric carcinoma malignant pancreatic neoplasm peripheral neuropathy exocrine pancreatic carcinoma hepatocellular carcinoma ovarian cancer tuberculosis gastric cancer lymphoplasmacytic lymphoma peripheral nervous system disease
D	Pharos: Q92759	autism spectrum disorder Hashimoto thyroiditis oropharynx cancer swine influenza cutaneous lupus erythematosus lung carcinoma psoriatic arthritis systemic lupus erythematosus endogenous depression membranous glomerulonephritis squamous cell lung carcinoma
F	Pharos: Q13889	adenoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor malignant glioma ovarian cancer Pick disease glioblastoma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma psoriasis
G	Pharos: Q6ZYL4	trichothiodystrophy 3, photosensitive trichothiodystrophy photosensitive trichothiodystrophy acute myeloid leukemia glioblastoma leukodystrophy osteosarcoma pilocytic astrocytoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor intellectual disability lung cancer ovarian cancer pituitary cancer trichothiodystrophy 1, photosensitive trichothiodystrophy 3, photosensitive trichothiodystrophy photosensitive trichothiodystrophy acute myeloid leukemia glioblastoma leukodystrophy osteosarcoma pilocytic astrocytoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor intellectual disability lung cancer ovarian cancer pituitary cancer trichothiodystrophy 1, photosensitive xeroderma pigmentosum Cockayne syndrome large cell medulloblastoma malignant glioma polycystic ovary syndrome
H	Pharos: P51948	lung cancer prostate carcinoma