6MHQ

Structure of connexin-46 intercellular gap junction channel at 3.4 angstrom resolution by cryoEM

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Connexin-like	8079720	4005615	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Claudin-like	8092544	3002606	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Claudin-like	8092544	3002606	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00029	e6mhqA1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
B	PF00029	e6mhqB1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
C	PF00029	e6mhqC1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
D	PF00029	e6mhqD1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
E	PF00029	e6mhqE1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
F	PF00029	e6mhqF1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
G	PF00029	e6mhqG1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
H	PF00029	e6mhqH1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
I	PF00029	e6mhqI1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
J	PF00029	e6mhqJ1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
K	PF00029	e6mhqK1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)
L	PF00029	e6mhqL1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF00029	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00029	Connexin (Connexin)	Connexin	Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Gap junction alpha-3 protein, connexin-46	wide pore channel activity passive transmembrane transporter activity gap junction hemi-channel activity channel activity transporter activity gap junction channel activity transmembrane transporter activity	cellular process cell communication multicellular organismal process sensory perception of light stimulus system process sensory perception nervous system process visual perception gap junction-mediated intercellular transport localization intercellular transport transport establishment of localization	cell-cell junction protein-containing complex anchoring junction plasma membrane protein complex gap junction membrane plasma membrane membrane protein complex cellular anatomical entity cell periphery cell junction connexin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR038359	Connexin, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000500	Connexin	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013092	Connexin, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR019570	Gap junction protein, cysteine-rich domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR002262	Gap junction alpha-3 protein (Cx46)	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR034634	Connexin, C-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR017990	Connexin, conserved site	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	OPM	Transmembrane	Alpha-helical polytopic	Tetraspan junctional complexes	Connexin

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Gap Junctions and Related Channels	connexin (Cx)-46/50 intercellular gap junction channels. Cx46 channel

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.