6MGG

Succinyl-CoA synthase from Francisella tularensis, phosphorylated, in complex with CoA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6mgga1	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
A	d6mgga2	Alpha and beta proteins (a/b)	Flavodoxin-like	Succinyl-CoA synthetase domains	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
A	d6mgga3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
C	d6mggc1	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
C	d6mggc2	Alpha and beta proteins (a/b)	Flavodoxin-like	Succinyl-CoA synthetase domains	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
C	d6mggc3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
B	d6mggb2	Alpha and beta proteins (a/b)	Flavodoxin-like	Succinyl-CoA synthetase domains	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
B	d6mggb1	Alpha and beta proteins (a+b)	ATP-grasp	Glutathione synthetase ATP-binding domain-like	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
D	d6mggd2	Alpha and beta proteins (a/b)	Flavodoxin-like	Succinyl-CoA synthetase domains	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
D	d6mggd1	Alpha and beta proteins (a+b)	ATP-grasp	Glutathione synthetase ATP-binding domain-like	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02629	e6mggA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF02629	ECOD (1.6)
A	PF00549	e6mggA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Succinyl-CoA synthetase domains (From Topology)	T: Succinyl-CoA synthetase domains	F: PF00549	ECOD (1.6)
C	PF02629	e6mggC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF02629	ECOD (1.6)
C	PF00549	e6mggC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Succinyl-CoA synthetase domains (From Topology)	T: Succinyl-CoA synthetase domains	F: PF00549	ECOD (1.6)
B	PF08442	e6mggB2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: PF08442	ECOD (1.6)
B	PF00549	e6mggB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Succinyl-CoA synthetase domains (From Topology)	T: Succinyl-CoA synthetase domains	F: PF00549	ECOD (1.6)
D	PF08442	e6mggD2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: PF08442	ECOD (1.6)
D	PF00549	e6mggD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Succinyl-CoA synthetase domains (From Topology)	T: Succinyl-CoA synthetase domains	F: PF00549	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.40.50.261	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Succinyl-CoA synthetase domains	CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C	3.40.50.261	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Succinyl-CoA synthetase domains	CATH (4.3.0)
B	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (utative)
B	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (utative)
B	3.40.50.261	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Succinyl-CoA synthetase domains	CATH (utative)
D	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (utative)
D	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (utative)
D	3.40.50.261	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Succinyl-CoA synthetase domains	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF02629	CoA binding domain (CoA_binding)	CoA binding domain	This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.	Domain
A, C	PF00549	CoA-ligase (Ligase_CoA)	CoA-ligase	This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP.	Domain
B, D	PF08442	ATP-grasp domain (ATP-grasp_2)	ATP-grasp domain	-	Domain
B, D	PF00549	CoA-ligase (Ligase_CoA)	CoA-ligase	This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Succinate--CoA ligase [ADP-forming] subunit alpha	succinate-CoA ligase (ADP-forming) activity succinate-CoA ligase activity ligase activity, forming carbon-sulfur bonds catalytic activity acid-thiol ligase activity ligase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding succinate-CoA ligase (GDP-forming) activity	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process primary metabolic process generation of precursor metabolites and energy	-
B, D	Succinate--CoA ligase [ADP-forming] subunit beta	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding succinate-CoA ligase (ADP-forming) activity succinate-CoA ligase activity ligase activity, forming carbon-sulfur bonds catalytic activity acid-thiol ligase activity ligase activity succinate-CoA ligase (GDP-forming) activity	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process primary metabolic process generation of precursor metabolites and energy	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, C	IPR005810	Succinyl-CoA ligase, alpha subunit	Family
A, C	IPR005811	ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain	Domain
A, C	IPR016102	Succinyl-CoA synthetase-like	Homologous Superfamily
A, C	IPR017440	ATP-citrate lyase/succinyl-CoA ligase, active site	Active Site
A, C	IPR033847	ATP-citrate lyase/succinyl-CoA ligase, conserved site	Conserved Site
A, C	IPR003781	CoA-binding	Domain
B, D	IPR011761	ATP-grasp fold	Domain
B, D	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
B, D	IPR016102	Succinyl-CoA synthetase-like	Homologous Superfamily
B, D	IPR013650	ATP-grasp fold, succinyl-CoA synthetase-type	Domain
B, D	IPR017866	Succinyl-CoA synthetase, beta subunit, conserved site	Conserved Site
B, D	IPR005811	ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain	Domain
B, D	IPR005809	Succinate--CoA ligase-like, beta subunit	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, C	NEP	Parent Component: HIS RESID: AA0035 PSI-MOD : 1'-phospho-L-histidine MOD:00044

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.