6MG1

C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2 Crystal Form

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Leucine zipper-like	8044461	3001609	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Leucine zipper-like	8044461	3001609	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e6mg1A1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6mg1B1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07716	Basic region leucine zipper (bZIP_2)	Basic region leucine zipper	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CCAAT/enhancer-binding protein beta	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding kinase binding ubiquitin-like protein ligase binding identical protein binding protein homodimerization activity protein dimerization activity protein-containing complex binding chromatin binding chromatin DNA binding histone acetyltransferase binding	developmental process mammary gland epithelial cell differentiation epithelium development cellular developmental process mammary gland development gland development animal organ development tissue development epithelial cell differentiation mammary gland epithelium development cell differentiation anatomical structure development cellular process regulation of defense response developmental process mammary gland epithelial cell differentiation epithelium development cellular developmental process mammary gland development gland development animal organ development tissue development epithelial cell differentiation mammary gland epithelium development cell differentiation anatomical structure development cellular process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response myeloid cell differentiation hemopoiesis myeloid cell development cell development negative regulation of lymphocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of leukocyte differentiation regulation of developmental process mononuclear cell differentiation regulation of cell differentiation regulation of cell development multicellular organism development regulation of multicellular organismal development regulation of dendritic cell differentiation regulation of hemopoiesis dendritic cell differentiation leukocyte differentiation biological process involved in interspecies interaction between organisms response to other organism response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus gonad development reproductive system development reproductive process female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development system development cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process acute-phase response acute inflammatory response cellular response to acid chemical cellular response to stimulus cellular response to amino acid stimulus response to acid chemical response to organic substance cellular response to chemical stimulus response to chemical response to amino acid fat cell differentiation brown fat cell differentiation regulation of biomineral tissue development positive regulation of developmental process positive regulation of biomineral tissue development biomineral tissue development interleukin-6 production regulation of interleukin-6 production regulation of cytokine production cytokine production signaling integrated stress response signaling intracellular signal transduction cell communication cellular response to stress intracellular signaling cassette signal transduction negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of fat cell differentiation positive regulation of cell differentiation regulation of fat cell differentiation positive regulation of cellular process regulation of localization sodium-dependent phosphate transport regulation of transport transport regulation of phosphate transport regulation of sodium-dependent phosphate transport establishment of localization localization positive regulation of transport positive regulation of sodium-dependent phosphate transport phosphate ion transport inorganic anion transport positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to endoplasmic reticulum stress immune response chronic inflammatory response granuloma formation immune effector process animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration nervous system development generation of neurons neurogenesis neuron differentiation regulation of odontoblast differentiation regulation of epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation placenta development chordate embryonic development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development epithelial cell proliferation mammary gland epithelial cell proliferation neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process epithelial cell proliferation involved in liver morphogenesis anatomical structure morphogenesis gland morphogenesis hepatocyte proliferation animal organ morphogenesis liver morphogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process myeloid leukocyte differentiation regulation of osteoclast differentiation osteoclast differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation ossification intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress apoptotic signaling pathway intrinsic apoptotic signaling pathway CD4-positive, alpha-beta T cell activation T-helper 1 cell activation alpha-beta T cell activation regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production positive regulation of gene expression positive regulation of cytokine production response to lipid response to oxygen-containing compound response to lipopolysaccharide response to molecule of bacterial origin	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear matrix RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex CHOP-C/EBP complex nucleoplasm C/EBP complex chromosomal region chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome
C, D	16-bp methylated oligonucleotide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR031106	CCAAT/enhancer-binding protein C/EBP	Family
A, B	IPR004827	Basic-leucine zipper domain	Domain
A, B	IPR016468	CCAAT/enhancer-binding protein, chordates	Family
A, B	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P17676	pulmonary fibrosis female infertility brain ischemia large cell medulloblastoma lung carcinoma medulloblastoma pituitary cancer astrocytic tumor ulcerative colitis Brain Injuries, Focal glioblastoma idiopathic interstitial pneumonia malignant pancreatic neoplasm ovarian cancer plasma cell myeloma pulmonary fibrosis female infertility brain ischemia large cell medulloblastoma lung carcinoma medulloblastoma pituitary cancer astrocytic tumor ulcerative colitis Brain Injuries, Focal glioblastoma idiopathic interstitial pneumonia malignant pancreatic neoplasm ovarian cancer plasma cell myeloma B-cell chronic lymphocytic leukemia brain injury breast cancer lung cancer MALT lymphoma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor cancer fatty liver disease gastric carcinoma hepatocellular carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.