6LYH

Crystal structure of tea N9-methyltransferase CkTcS in complex with SAH and 1,3,7-trimethyluric acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d6lyhb_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
B [auth A]	d6lyha_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
C	d6lyhc_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
D	d6lyhd_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
E	d6lyhe_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
F	d6lyhf_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
G	d6lyhg_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)
H	d6lyhh_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	(Camellia sinensis var. assamica ) [TaxId: 261999 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)
D	SCOP2 Family	Salicylic acid carboxyl methyltransferase (SAMT)-like	8095778	4001150	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8095779	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF03492	e6lyhB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
B [auth A]	PF03492	e6lyhA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
C	PF03492	e6lyhC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
D	PF03492	e6lyhD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
E	PF03492	e6lyhE1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
F	PF03492	e6lyhF1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
G	PF03492	e6lyhG1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)
H	PF03492	e6lyhH1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF03492	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	PF03492	SAM dependent carboxyl methyltransferase (Methyltransf_7)	SAM dependent carboxyl methyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	N-methyltransferase CkTcS	transferase activity, transferring one-carbon groups transferase activity methyltransferase activity catalytic activity paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity cation binding ion binding binding metal ion binding small molecule binding	methylation metabolic process organonitrogen compound metabolic process organic substance metabolic process alkaloid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR042086	Methyltransferase, alpha-helical capping domain	Homologous Superfamily
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR005299	SAM dependent carboxyl methyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.