6LXW

Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth P]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054529	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF00047	e6lxwD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00047	ECOD (1.6)
D	PF07654	e6lxwD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A	PF00047	e6lxwA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00047	ECOD (1.6)
A	PF07654	e6lxwA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B	PF00047	e6lxwB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00047	ECOD (1.6)
B	PF07654	e6lxwB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C	PF00047	e6lxwC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00047	ECOD (1.6)
C	PF07654	e6lxwC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F [auth P]	PF07686	e6lxwP4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
F [auth P]	Polymeric immunoglobulin receptor, PIGR	1V-LIKE	Homo sapiens (human)	PIGR	V-LIKE-DOMAIN V-LIKE	RPI	PIGR	IMGT (202418-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
A, B, C, D	PF00047	Immunoglobulin domain (ig)	Immunoglobulin domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prot ...	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.	Domain
E [auth J]	PF15097	Immunoglobulin J chain (Ig_J_chain)	Immunoglobulin J chain	-	Family
F [auth P]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Interleukin-2,Immunoglobulin heavy constant alpha 1	binding antigen binding protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity enzyme regulator activity kinase activator activity enzyme activator activity kinase regulator activity binding antigen binding protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity enzyme regulator activity kinase activator activity enzyme activator activity kinase regulator activity kappa-type opioid receptor binding G protein-coupled receptor binding opioid receptor binding cytokine receptor binding growth factor receptor binding interleukin-2 receptor binding glycosphingolipid binding sphingolipid binding lipid binding glycolipid binding carbohydrate derivative binding carbohydrate binding cytokine activity	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway biological regulation regulation of response to stimulus immune system process regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response adaptive immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin leukocyte mediated immunity complement activation, classical pathway immunoglobulin mediated immune response immune effector process B cell mediated immunity biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus multicellular organismal process renal system process system process glomerular filtration renal filtration positive regulation of metabolic process positive regulation of respiratory burst respiratory burst metabolic process regulation of respiratory burst regulation of metabolic process regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process multicellular organism development organic substance biosynthetic process positive regulation of macromolecule metabolic process system development positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response cellular metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of gene expression biosynthetic process positive regulation of DNA metabolic process positive regulation of production of molecular mediator of immune response regulation of macromolecule biosynthetic process regulation of DNA metabolic process immunoglobulin production regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination positive regulation of cellular metabolic process somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments positive regulation of biosynthetic process regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of cellular process production of molecular mediator of immune response positive regulation of immunoglobulin production regulation of isotype switching cell activation regulation of macromolecule metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression somatic diversification of immune receptors via germline recombination within a single locus positive regulation of cellular biosynthetic process regulation of lymphocyte activation regulation of immune effector process regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response nucleobase-containing compound metabolic process positive regulation of developmental process positive regulation of cell activation anatomical structure development positive regulation of leukocyte activation somatic diversification of immune receptors regulation of nucleobase-containing compound metabolic process positive regulation of adaptive immune response somatic recombination of immunoglobulin genes involved in immune response developmental process positive regulation of nucleobase-containing compound metabolic process regulation of adaptive immune response regulation of cellular metabolic process regulation of B cell mediated immunity somatic diversification of immunoglobulins organic cyclic compound metabolic process regulation of leukocyte mediated immunity positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response macromolecule metabolic process isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity cellular biosynthetic process lymphocyte activation positive regulation of B cell mediated immunity leukocyte activation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains organic substance metabolic process positive regulation of isotype switching to IgG isotypes regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of biosynthetic process B cell activation gene expression positive regulation of B cell activation regulation of isotype switching to IgG isotypes regulation of lymphocyte mediated immunity regulation of immunoglobulin production isotype switching to IgG isotypes regulation of defense response regulation of response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress positive regulation of defense response inflammatory response regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation cell-cell signaling regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation mature B cell differentiation positive regulation of B cell differentiation lymphocyte differentiation regulation of cell development regulation of plasma cell differentiation cell differentiation positive regulation of cell development positive regulation of plasma cell differentiation plasma cell differentiation leukocyte differentiation cellular developmental process cell development regulation of B cell differentiation B cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development mature B cell differentiation involved in immune response hemopoiesis regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation cell projection organization positive regulation of dendritic spine development regulation of dendritic spine development neuron projection development cellular component organization neurogenesis neuron differentiation dendrite development cellular component organization or biogenesis dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development T cell activation T cell differentiation signal transduction in absence of ligand cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death positive regulation of tissue remodeling tissue remodeling regulation of tissue remodeling natural killer cell activation cell adhesion homeostatic process T cell homeostatic proliferation leukocyte proliferation T cell homeostasis lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation regulation of T cell activation regulation of T cell proliferation multicellular organismal-level homeostasis regulation of T cell homeostatic proliferation leukocyte homeostasis regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation homeostasis of number of cells lymphocyte homeostasis positive regulation of cell population proliferation positive regulation of B cell proliferation regulation of B cell proliferation positive regulation of mononuclear cell proliferation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of leukocyte proliferation DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process regulation of B cell apoptotic process negative regulation of programmed cell death leukocyte apoptotic process regulation of apoptotic process B cell apoptotic process regulation of programmed cell death negative regulation of B cell apoptotic process lymphocyte apoptotic process negative regulation of apoptotic process negative regulation of leukocyte apoptotic process negative regulation of lymphocyte apoptotic process regulation of growth regulation of cellular component organization growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth positive regulation of cytosolic calcium ion concentration regulation of biological quality regulation of alpha-beta T cell activation regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation CD4-positive, alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation response to organic substance interleukin-2-mediated signaling pathway cellular response to interleukin-2 response to cytokine cytokine-mediated signaling pathway response to interleukin-2 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance positive regulation of T cell differentiation positive regulation of T cell activation positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation cell-cell adhesion regulation of cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion regulation of regulatory T cell differentiation regulatory T cell differentiation negative regulation of inflammatory response negative regulation of response to stimulus negative regulation of response to external stimulus negative regulation of defense response protein kinase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to alcohol response to oxygen-containing compound response to ethanol negative regulation of lymphocyte proliferation negative regulation of lymphocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation negative regulation of cell population proliferation negative regulation of cell activation negative regulation of immune system process negative regulation of multicellular organismal process negative regulation of leukocyte activation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of activated T cell proliferation activated T cell proliferation response to tacrolimus response to organonitrogen compound response to nitrogen compound response to organic cyclic compound positive regulation of phosphorylation positive regulation of phosphate metabolic process peptidyl-amino acid modification positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein positive regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT cytokine production regulation of cytokine production interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of cytokine production alpha-beta T cell differentiation involved in immune response negative regulation of cell adhesion negative regulation of T cell differentiation regulation of T-helper cell differentiation T-helper cell differentiation negative regulation of leukocyte differentiation negative regulation of immune effector process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion T-helper 17 cell differentiation negative regulation of T-helper 17 cell differentiation CD4-positive, alpha-beta T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response negative regulation of cell differentiation regulation of T-helper 17 cell differentiation negative regulation of developmental process negative regulation of T-helper 17 type immune response negative regulation of cell development negative regulation of alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation involved in immune response negative regulation of hemopoiesis negative regulation of immune response negative regulation of adaptive immune response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of lymphocyte differentiation negative regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation alpha-beta T cell activation involved in immune response regulation of T-helper 17 type immune response T cell differentiation involved in immune response negative regulation of T-helper cell differentiation T-helper 17 type immune response regulation of type II interferon production type II interferon production positive regulation of type II interferon production	protein-containing complex IgA immunoglobulin complex immunoglobulin complex IgA immunoglobulin complex, circulating secretory IgA immunoglobulin complex extracellular region extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex IgA immunoglobulin complex immunoglobulin complex IgA immunoglobulin complex, circulating secretory IgA immunoglobulin complex extracellular region extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane dimeric IgA immunoglobulin complex secretory dimeric IgA immunoglobulin complex IgG immunoglobulin complex blood microparticle monomeric IgA immunoglobulin complex
E [auth J]	Immunoglobulin J chain	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein-containing complex binding immunoglobulin binding IgA binding signaling receptor binding immunoglobulin receptor binding protein-macromolecule adaptor activity molecular adaptor activity antigen binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of metabolic process regulation of biological process positive regulation of respiratory burst respiratory burst biological regulation positive regulation of biological process metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of metabolic process regulation of biological process positive regulation of respiratory burst respiratory burst biological regulation positive regulation of biological process metabolic process regulation of respiratory burst regulation of metabolic process response to stimulus immune response immune system process adaptive immune response humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus innate immune response multicellular organismal process renal system process system process glomerular filtration renal filtration	extracellular region extracellular space cellular anatomical entity blood microparticle IgA immunoglobulin complex, circulating dimeric IgA immunoglobulin complex protein-containing complex IgA immunoglobulin complex polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex secretory IgA immunoglobulin complex extracellular exosome membrane-bounded organelle extracellular region extracellular space cellular anatomical entity blood microparticle IgA immunoglobulin complex, circulating dimeric IgA immunoglobulin complex protein-containing complex IgA immunoglobulin complex polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex secretory IgA immunoglobulin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle monomeric IgA immunoglobulin complex IgM immunoglobulin complex IgM immunoglobulin complex, circulating pentameric IgM immunoglobulin complex secretory dimeric IgA immunoglobulin complex
F [auth P]	Polymeric immunoglobulin receptor	polymeric immunoglobulin binding protein-containing complex binding binding immunoglobulin binding molecular transducer activity immunoglobulin receptor activity transmembrane signaling receptor activity signaling receptor activity polymeric immunoglobulin receptor activity immune receptor activity	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling immune response biological regulation cell communication Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling immune response biological regulation cell communication Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process regulation of immune system process signal transduction cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway protein localization localization cellular localization receptor clustering cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane multicellular organismal process transport establishment of localization immunoglobulin transcytosis in epithelial cells vesicle-mediated transport immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor transcytosis mucosal immune response organ or tissue specific immune response system process nervous system process detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of taste detection of stimulus sensory perception of chemical stimulus sensory perception sensory perception of taste response to chemical detection of chemical stimulus sensory perception of bitter taste detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception	protein-containing complex receptor complex IgA immunoglobulin complex, circulating secretory IgA immunoglobulin complex extracellular region IgA immunoglobulin complex extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex receptor complex IgA immunoglobulin complex, circulating secretory IgA immunoglobulin complex extracellular region IgA immunoglobulin complex extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle lytic vacuole endomembrane system intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle lysosome vacuolar membrane membrane azurophil granule vacuole intracellular membrane-bounded organelle lytic vacuole membrane cytoplasmic vesicle membrane lysosomal membrane secretory granule primary lysosome secretory vesicle azurophil granule membrane cytoplasm organelle membrane secretory granule membrane cell periphery plasma membrane
G [auth S]	SigA binding protein	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR003597	Immunoglobulin C1-set	Domain
A, B, C, D	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR013151	Immunoglobulin	Domain
A, B, C, D	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D	IPR000779	Interleukin-2	Family
A, B, C, D	IPR030477	Interleukin-2, conserved site	Conserved Site
A, B, C, D	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
E [auth J]	IPR024110	Immunoglobulin J chain	Family
F [auth P]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
F [auth P]	IPR003599	Immunoglobulin subtype	Domain
F [auth P]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
F [auth P]	IPR013106	Immunoglobulin V-set domain	Domain
F [auth P]	IPR007110	Immunoglobulin-like domain	Domain
G [auth S]	IPR005877	YSIRK Gram-positive signal peptide	Domain
G [auth S]	IPR038183	RICH domain superfamily	Homologous Superfamily
G [auth S]	IPR018337	Cell wall/choline-binding repeat	Repeat
G [auth S]	IPR007756	RICH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P60568	breast cancer psoriasis cancer leukopenia glomerulonephritis autoimmune hepatitis adult T-cell leukemia/lymphoma glioblastoma melanoma nephrotic syndrome Neoplasms, Experimental dissociative amnesia allergic contact dermatitis rheumatoid arthritis alopecia areata breast cancer psoriasis cancer leukopenia glomerulonephritis autoimmune hepatitis adult T-cell leukemia/lymphoma glioblastoma melanoma nephrotic syndrome Neoplasms, Experimental dissociative amnesia allergic contact dermatitis rheumatoid arthritis alopecia areata giant cell glioblastoma liver cancer anemia prostate cancer leukemia AIDS major depressive disorder asthma urinary bladder cancer HIV infectious disease autoimmune disease neutropenia influenza paranoid schizophrenia pneumonia kidney disease COVID-19 adult acute respiratory distress syndrome liver neoplasm lymphatic system disease arthritic joint disease autism urinary bladder neoplasm brain cancer inborn carbohydrate metabolic disorder brain injury peripheral nervous system disease juvenile idiopathic arthritis kidney neoplasm cutaneous melanoma lung benign neoplasm allergic disease schizophrenia lymphopenia systemic lupus erythematosus tuberculosis vaginal cancer benign neoplasm hypotensive disorder inflammatory bowel disease peripheral neuropathy breast disease kidney cancer celiac disease acute T cell leukemia diarrheal disease liver disease endogenous depression allergic rhinitis skin disease amnestic disorder
E [auth J]	Pharos: P01591	pancreatic intraductal papillary-mucinous neoplasm psoriasis B-cell chronic lymphocytic leukemia Bruton-type agammaglobulinemia cutaneous lupus erythematosus lung carcinoma malignant ependymoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma periodontitis tuberculosis breast cancer chronic kidney disease lung adenocarcinoma lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm psoriasis B-cell chronic lymphocytic leukemia Bruton-type agammaglobulinemia cutaneous lupus erythematosus lung carcinoma malignant ependymoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma periodontitis tuberculosis breast cancer chronic kidney disease lung adenocarcinoma lymphoplasmacytic lymphoma malignant glioma MALT lymphoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer ulcerative colitis breast carcinoma common variable immunodeficiency lung cancer malignant colon neoplasm malignant mesothelioma osteosarcoma
F [auth P]	Pharos: P01833	B-cell chronic lymphocytic leukemia endometriosis invasive ductal breast carcinoma lung carcinoma nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer head and neck cancer lung adenocarcinoma malignant colon neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma transitional cell carcinoma breast carcinoma B-cell chronic lymphocytic leukemia endometriosis invasive ductal breast carcinoma lung carcinoma nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer head and neck cancer lung adenocarcinoma malignant colon neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma transitional cell carcinoma breast carcinoma IgA glomerulonephritis lung cancer malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.